Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan

Detalhes bibliográficos
Autor(a) principal: Santos, K. S. C. R. dos
Data de Publicação: 2006
Outros Autores: Coelho, J. F. J., Ferreira, P., Pinto, I., Lorenzetti, S. G., Ferreira, E. I., Higa, O. Z., Gil, M. H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/3795
https://doi.org/10.1016/j.ijpharm.2005.11.019
Resumo: Chitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate as chemical initiator. Evidence for graft copolymerization of the vinyl monomers onto chitosan was obtained by FTIR and DMTA. Swelling degree, cytotoxicity, thrombogenicity and haemolytic activity of these membranes were evaluated. Chitosan-graft-AA-graft-HEMA showed to be the best matrix for drug delivery systems than chitosan-graft-AA because it retains good swelling properties, but the content in HEMA has improved cytocompatibility, hemocompatibility and thrombogenic character.
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spelling Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosanChitosanAcrylic acid2-Hydroxyethyl methacrylateMembranesWound healingChitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate as chemical initiator. Evidence for graft copolymerization of the vinyl monomers onto chitosan was obtained by FTIR and DMTA. Swelling degree, cytotoxicity, thrombogenicity and haemolytic activity of these membranes were evaluated. Chitosan-graft-AA-graft-HEMA showed to be the best matrix for drug delivery systems than chitosan-graft-AA because it retains good swelling properties, but the content in HEMA has improved cytocompatibility, hemocompatibility and thrombogenic character.http://www.sciencedirect.com/science/article/B6T7W-4J2M1S4-1/1/0bac95de859179c9f58b0059043d36fa2006info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/3795http://hdl.handle.net/10316/3795https://doi.org/10.1016/j.ijpharm.2005.11.019engInternational Journal of Pharmaceutics. 310:1-2 (2006) 37-45Santos, K. S. C. R. dosCoelho, J. F. J.Ferreira, P.Pinto, I.Lorenzetti, S. G.Ferreira, E. I.Higa, O. Z.Gil, M. H.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:49:07Zoai:estudogeral.uc.pt:10316/3795Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:16.268237Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
title Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
spellingShingle Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
Santos, K. S. C. R. dos
Chitosan
Acrylic acid
2-Hydroxyethyl methacrylate
Membranes
Wound healing
title_short Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
title_full Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
title_fullStr Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
title_full_unstemmed Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
title_sort Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan
author Santos, K. S. C. R. dos
author_facet Santos, K. S. C. R. dos
Coelho, J. F. J.
Ferreira, P.
Pinto, I.
Lorenzetti, S. G.
Ferreira, E. I.
Higa, O. Z.
Gil, M. H.
author_role author
author2 Coelho, J. F. J.
Ferreira, P.
Pinto, I.
Lorenzetti, S. G.
Ferreira, E. I.
Higa, O. Z.
Gil, M. H.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, K. S. C. R. dos
Coelho, J. F. J.
Ferreira, P.
Pinto, I.
Lorenzetti, S. G.
Ferreira, E. I.
Higa, O. Z.
Gil, M. H.
dc.subject.por.fl_str_mv Chitosan
Acrylic acid
2-Hydroxyethyl methacrylate
Membranes
Wound healing
topic Chitosan
Acrylic acid
2-Hydroxyethyl methacrylate
Membranes
Wound healing
description Chitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate as chemical initiator. Evidence for graft copolymerization of the vinyl monomers onto chitosan was obtained by FTIR and DMTA. Swelling degree, cytotoxicity, thrombogenicity and haemolytic activity of these membranes were evaluated. Chitosan-graft-AA-graft-HEMA showed to be the best matrix for drug delivery systems than chitosan-graft-AA because it retains good swelling properties, but the content in HEMA has improved cytocompatibility, hemocompatibility and thrombogenic character.
publishDate 2006
dc.date.none.fl_str_mv 2006
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/3795
http://hdl.handle.net/10316/3795
https://doi.org/10.1016/j.ijpharm.2005.11.019
url http://hdl.handle.net/10316/3795
https://doi.org/10.1016/j.ijpharm.2005.11.019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Pharmaceutics. 310:1-2 (2006) 37-45
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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