Chagas Disease

Detalhes bibliográficos
Autor(a) principal: Durães-Oliveira, João
Data de Publicação: 2024
Outros Autores: Palma-Marques, Joana, Moreno, Cláudia, Rodrigues, Armanda, Monteiro, Marta, Alexandre-Pires, Graça, da Fonseca, Isabel Pereira, Santos-Gomes, Gabriela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/170347
Resumo: Funding Information: This study was supported by FCT\u2014Foundation for Science and Technology, I.P., through research grants EXPL/CVT-CVT/0175/2021 (DOI 10.54499/EXPL/CVT-CVT/0175/2021) and PTDC/CVT-CVT/0228/2020 (DOI 10.54499/PTDC/CVT-CVT/0228/2020) and by national funds within the scope of Centro de Investiga\u00E7\u00E3o Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020), Al4AnimalS (LA/P/0059/2020), Global Health and Tropical Medicine (GHTM, UID/04413/2020) and LA-REAL (LA/P/0117/2020). Joana Palma Marques and Marta Monteiro have Ph.D. scholarship references 2021.05579BD and UI/BD/152819/2022, respectively. A. Rodrigues awards a CEECIND/CP1725/CT0023 (10.54499/2022.00499.CEECIND/CP1725/CT0023). Publisher Copyright: © 2024 by the authors.
id RCAP_8272b7f3398ff3252c37ff9816875c05
oai_identifier_str oai:run.unl.pt:10362/170347
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Chagas DiseaseA Silent Threat for Dogs and HumansChagas diseaseclinical signsdogsmedical advancesreservoirTrypanosoma cruzivaccineszoonotic infectionInfectious DiseasesParasitologyveterinary(all)SDG 3 - Good Health and Well-beingFunding Information: This study was supported by FCT\u2014Foundation for Science and Technology, I.P., through research grants EXPL/CVT-CVT/0175/2021 (DOI 10.54499/EXPL/CVT-CVT/0175/2021) and PTDC/CVT-CVT/0228/2020 (DOI 10.54499/PTDC/CVT-CVT/0228/2020) and by national funds within the scope of Centro de Investiga\u00E7\u00E3o Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020), Al4AnimalS (LA/P/0059/2020), Global Health and Tropical Medicine (GHTM, UID/04413/2020) and LA-REAL (LA/P/0117/2020). Joana Palma Marques and Marta Monteiro have Ph.D. scholarship references 2021.05579BD and UI/BD/152819/2022, respectively. A. Rodrigues awards a CEECIND/CP1725/CT0023 (10.54499/2022.00499.CEECIND/CP1725/CT0023). Publisher Copyright: © 2024 by the authors.Chagas disease (CD) is a vector-borne Neglected Zoonotic Disease (NZD) caused by a flagellate protozoan, Trypanosoma cruzi, that affects various mammalian species across America, including humans and domestic animals. However, due to an increase in population movements and new routes of transmission, T. cruzi infection is presently considered a worldwide health concern, no longer restricted to endemic countries. Dogs play a major role in the domestic cycle by acting very efficiently as reservoirs and allowing the perpetuation of parasite transmission in endemic areas. Despite the significant progress made in recent years, still there is no vaccine against human and animal disease, there are few drugs available for the treatment of human CD, and there is no standard protocol for the treatment of canine CD. In this review, we highlight human and canine Chagas Disease in its different dimensions and interconnections. Dogs, which are considered to be the most important peridomestic reservoir and sentinel for the transmission of T. cruzi infection in a community, develop CD that is clinically similar to human CD. Therefore, an integrative approach, based on the One Health concept, bringing together the advances in genomics, immunology, and epidemiology can lead to the effective development of vaccines, new treatments, and innovative control strategies to tackle CD.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNDurães-Oliveira, JoãoPalma-Marques, JoanaMoreno, CláudiaRodrigues, ArmandaMonteiro, MartaAlexandre-Pires, Graçada Fonseca, Isabel PereiraSantos-Gomes, Gabriela2024-08-05T22:15:56Z2024-042024-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/170347eng1422-0067PURE: 95554576https://doi.org/10.3390/ijms25073840info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-07T01:37:48Zoai:run.unl.pt:10362/170347Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-07T01:37:48Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chagas Disease
A Silent Threat for Dogs and Humans
title Chagas Disease
spellingShingle Chagas Disease
Durães-Oliveira, João
Chagas disease
clinical signs
dogs
medical advances
reservoir
Trypanosoma cruzi
vaccines
zoonotic infection
Infectious Diseases
Parasitology
veterinary(all)
SDG 3 - Good Health and Well-being
title_short Chagas Disease
title_full Chagas Disease
title_fullStr Chagas Disease
title_full_unstemmed Chagas Disease
title_sort Chagas Disease
author Durães-Oliveira, João
author_facet Durães-Oliveira, João
Palma-Marques, Joana
Moreno, Cláudia
Rodrigues, Armanda
Monteiro, Marta
Alexandre-Pires, Graça
da Fonseca, Isabel Pereira
Santos-Gomes, Gabriela
author_role author
author2 Palma-Marques, Joana
Moreno, Cláudia
Rodrigues, Armanda
Monteiro, Marta
Alexandre-Pires, Graça
da Fonseca, Isabel Pereira
Santos-Gomes, Gabriela
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
Vector borne diseases and pathogens (VBD)
RUN
dc.contributor.author.fl_str_mv Durães-Oliveira, João
Palma-Marques, Joana
Moreno, Cláudia
Rodrigues, Armanda
Monteiro, Marta
Alexandre-Pires, Graça
da Fonseca, Isabel Pereira
Santos-Gomes, Gabriela
dc.subject.por.fl_str_mv Chagas disease
clinical signs
dogs
medical advances
reservoir
Trypanosoma cruzi
vaccines
zoonotic infection
Infectious Diseases
Parasitology
veterinary(all)
SDG 3 - Good Health and Well-being
topic Chagas disease
clinical signs
dogs
medical advances
reservoir
Trypanosoma cruzi
vaccines
zoonotic infection
Infectious Diseases
Parasitology
veterinary(all)
SDG 3 - Good Health and Well-being
description Funding Information: This study was supported by FCT\u2014Foundation for Science and Technology, I.P., through research grants EXPL/CVT-CVT/0175/2021 (DOI 10.54499/EXPL/CVT-CVT/0175/2021) and PTDC/CVT-CVT/0228/2020 (DOI 10.54499/PTDC/CVT-CVT/0228/2020) and by national funds within the scope of Centro de Investiga\u00E7\u00E3o Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020), Al4AnimalS (LA/P/0059/2020), Global Health and Tropical Medicine (GHTM, UID/04413/2020) and LA-REAL (LA/P/0117/2020). Joana Palma Marques and Marta Monteiro have Ph.D. scholarship references 2021.05579BD and UI/BD/152819/2022, respectively. A. Rodrigues awards a CEECIND/CP1725/CT0023 (10.54499/2022.00499.CEECIND/CP1725/CT0023). Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-08-05T22:15:56Z
2024-04
2024-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/170347
url http://hdl.handle.net/10362/170347
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-0067
PURE: 95554576
https://doi.org/10.3390/ijms25073840
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817547151264186368