Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events

Detalhes bibliográficos
Autor(a) principal: Carvalho, Cristina
Data de Publicação: 2018
Outros Autores: Moreira, Paula I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.3389/fphys.2018.00806
Texto Completo: http://hdl.handle.net/10316/107637
https://doi.org/10.3389/fphys.2018.00806
Resumo: The brain is one of the most exquisite organs in the body with high metabolic demands, and requires a tight regulation of the surrounding environment. This tight control is exerted by the neurovascular unit (NVU) comprising different cell types, where endothelial cells play the commander-in-chief role. Thus, it is assumable that even slight perturbations in NVU might affect, in some cases irreversibly, brain homeostasis and health. In this line, recent findings support the two-hit vascular hypothesis for neurodegenerative conditions, where vascular dysfunction underlies the development of neurodegenerative diseases, such as Alzheimer's disease (AD). Knowing that endothelial cells are rich in mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, two major reactive oxygen species (ROS) sources, this review aims to gather information on how oxidative stress is in the front line of vascular alterations observed in brain aging and neurodegenerative conditions, particularly AD. Also, a brief discussion about the therapeutic strategies aimed to protect against cerebrovascular diseases is included.
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spelling Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Eventsneurovascular unitendothelial cellsoxidative stressmitochondriaNADPH oxidasesAlzheimer’s diseaseThe brain is one of the most exquisite organs in the body with high metabolic demands, and requires a tight regulation of the surrounding environment. This tight control is exerted by the neurovascular unit (NVU) comprising different cell types, where endothelial cells play the commander-in-chief role. Thus, it is assumable that even slight perturbations in NVU might affect, in some cases irreversibly, brain homeostasis and health. In this line, recent findings support the two-hit vascular hypothesis for neurodegenerative conditions, where vascular dysfunction underlies the development of neurodegenerative diseases, such as Alzheimer's disease (AD). Knowing that endothelial cells are rich in mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, two major reactive oxygen species (ROS) sources, this review aims to gather information on how oxidative stress is in the front line of vascular alterations observed in brain aging and neurodegenerative conditions, particularly AD. Also, a brief discussion about the therapeutic strategies aimed to protect against cerebrovascular diseases is included.Frontiers Media S.A.2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107637http://hdl.handle.net/10316/107637https://doi.org/10.3389/fphys.2018.00806eng1664-042XCarvalho, CristinaMoreira, Paula I.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-25T10:54:39Zoai:estudogeral.uc.pt:10316/107637Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:58.111705Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
title Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
spellingShingle Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
Carvalho, Cristina
neurovascular unit
endothelial cells
oxidative stress
mitochondria
NADPH oxidases
Alzheimer’s disease
Carvalho, Cristina
neurovascular unit
endothelial cells
oxidative stress
mitochondria
NADPH oxidases
Alzheimer’s disease
title_short Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
title_full Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
title_fullStr Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
title_full_unstemmed Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
title_sort Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
author Carvalho, Cristina
author_facet Carvalho, Cristina
Carvalho, Cristina
Moreira, Paula I.
Moreira, Paula I.
author_role author
author2 Moreira, Paula I.
author2_role author
dc.contributor.author.fl_str_mv Carvalho, Cristina
Moreira, Paula I.
dc.subject.por.fl_str_mv neurovascular unit
endothelial cells
oxidative stress
mitochondria
NADPH oxidases
Alzheimer’s disease
topic neurovascular unit
endothelial cells
oxidative stress
mitochondria
NADPH oxidases
Alzheimer’s disease
description The brain is one of the most exquisite organs in the body with high metabolic demands, and requires a tight regulation of the surrounding environment. This tight control is exerted by the neurovascular unit (NVU) comprising different cell types, where endothelial cells play the commander-in-chief role. Thus, it is assumable that even slight perturbations in NVU might affect, in some cases irreversibly, brain homeostasis and health. In this line, recent findings support the two-hit vascular hypothesis for neurodegenerative conditions, where vascular dysfunction underlies the development of neurodegenerative diseases, such as Alzheimer's disease (AD). Knowing that endothelial cells are rich in mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, two major reactive oxygen species (ROS) sources, this review aims to gather information on how oxidative stress is in the front line of vascular alterations observed in brain aging and neurodegenerative conditions, particularly AD. Also, a brief discussion about the therapeutic strategies aimed to protect against cerebrovascular diseases is included.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/107637
http://hdl.handle.net/10316/107637
https://doi.org/10.3389/fphys.2018.00806
url http://hdl.handle.net/10316/107637
https://doi.org/10.3389/fphys.2018.00806
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-042X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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dc.identifier.doi.none.fl_str_mv 10.3389/fphys.2018.00806

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