Nuclear positioning in skeletal muscle

Detalhes bibliográficos
Autor(a) principal: Roman, William
Data de Publicação: 2018
Outros Autores: Gomes, Edgar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54753
Resumo: © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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spelling Nuclear positioning in skeletal muscleCytoskeletonMuscle developmentMuscle disordersMyogenesisNuclear movement© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)Skeletal muscle cells possess a unique cellular architecture designed to fulfill their contractile function. Muscle cells (also known as myofibers) result from the fusion of hundreds of myoblasts and grow into a fiber of several centimeters in length. Cellular structures gradually become organized during muscle development to raise a mature contractile cell. A hallmark of this singular cell architecture is the position of nuclei at the periphery of the myofiber, below the plasma membrane. Nuclei in myofibers are evenly distributed except in specialized regions like the neuromuscular or myotendinous junctions. Disruption of nuclear positioning results in hindered muscle contraction and occurs in a multitude of muscle disorders as well as in regenerative myofibers. We will explore in this review the step by step nuclear migrations during myogenesis for nuclei to reach their evenly distributed anchored position at the periphery.This work was supported by the European Research Council, EMBO, LISBOA-01-0145-FEDER-007391 co-funded by FEDER through POR Lisboa 2020 – Programa Operacional Regional de Lisboa, PORTUGAL 2020, and Fundação para a Ciência e a Tecnologia.ElsevierRepositório da Universidade de LisboaRoman, WilliamGomes, Edgar2022-10-12T15:31:04Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54753engSemin Cell Dev Biol. 2018 Oct;82:51-561084-952110.1016/j.semcdb.2017.11.0051096-3634info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:20Zoai:repositorio.ul.pt:10451/54753Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:31.559975Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nuclear positioning in skeletal muscle
title Nuclear positioning in skeletal muscle
spellingShingle Nuclear positioning in skeletal muscle
Roman, William
Cytoskeleton
Muscle development
Muscle disorders
Myogenesis
Nuclear movement
title_short Nuclear positioning in skeletal muscle
title_full Nuclear positioning in skeletal muscle
title_fullStr Nuclear positioning in skeletal muscle
title_full_unstemmed Nuclear positioning in skeletal muscle
title_sort Nuclear positioning in skeletal muscle
author Roman, William
author_facet Roman, William
Gomes, Edgar
author_role author
author2 Gomes, Edgar
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Roman, William
Gomes, Edgar
dc.subject.por.fl_str_mv Cytoskeleton
Muscle development
Muscle disorders
Myogenesis
Nuclear movement
topic Cytoskeleton
Muscle development
Muscle disorders
Myogenesis
Nuclear movement
description © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2022-10-12T15:31:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54753
url http://hdl.handle.net/10451/54753
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Semin Cell Dev Biol. 2018 Oct;82:51-56
1084-9521
10.1016/j.semcdb.2017.11.005
1096-3634
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.mail.fl_str_mv
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