Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells

Detalhes bibliográficos
Autor(a) principal: Roman, William
Data de Publicação: 2018
Outros Autores: Martins, João P., Gomes, Edgar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50208
Resumo: © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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spelling Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cellsCell-cell interactionExtracellular matrix signalingFibronectinMuscle developmentNuclear movementNuclear position© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Skeletal muscle cells (myofibers) are rod-shaped multinucleated cells surrounded by an extracellular matrix (ECM) basal lamina. In contrast to other cell types, nuclei in myofibers are positioned just below the plasma membrane at the cell periphery. Peripheral nuclear positioning occurs during myogenesis and is driven by myofibril crosslinking and contraction. Here we show that peripheral nuclear positioning is triggered by local accumulation of fibronectin secreted by myofibroblasts. We demonstrate that fibronectin via α5-integrin mediates peripheral nuclear positioning dependent on FAK and Src activation. Finally, we show that Cdc42, downstream of restricted fibronectin activation, is required for myofibril crosslinking but not myofibril contraction. Thus we identify that local activation of integrin by fibronectin secreted by myofibroblasts activates peripheral nuclear positioning in skeletal myofibers.ElsevierRepositório da Universidade de LisboaRoman, WilliamMartins, João P.Gomes, Edgar2021-11-29T17:21:10Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50208engDev Cell. 2018 Jul 2;46(1):102-111.e61534-580710.1016/j.devcel.2018.05.0311534-5807info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:09Zoai:repositorio.ul.pt:10451/50208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:36.820276Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
title Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
spellingShingle Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
Roman, William
Cell-cell interaction
Extracellular matrix signaling
Fibronectin
Muscle development
Nuclear movement
Nuclear position
title_short Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
title_full Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
title_fullStr Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
title_full_unstemmed Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
title_sort Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
author Roman, William
author_facet Roman, William
Martins, João P.
Gomes, Edgar
author_role author
author2 Martins, João P.
Gomes, Edgar
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Roman, William
Martins, João P.
Gomes, Edgar
dc.subject.por.fl_str_mv Cell-cell interaction
Extracellular matrix signaling
Fibronectin
Muscle development
Nuclear movement
Nuclear position
topic Cell-cell interaction
Extracellular matrix signaling
Fibronectin
Muscle development
Nuclear movement
Nuclear position
description © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-11-29T17:21:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50208
url http://hdl.handle.net/10451/50208
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dev Cell. 2018 Jul 2;46(1):102-111.e6
1534-5807
10.1016/j.devcel.2018.05.031
1534-5807
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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