SUVmax evaluation on [68Ga]Ga-DOTA-TATE PET/CT uptake in patients with neuroendocrine tumors: a literature review

• Autor(a) principal: Maricato, Carolina
• Data de Publicação: 2022
• Outros Autores: Aguiar, Isabel, Valente, Susana, Figueiredo, Sérgio
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.25758/set.747
• topic: SUVmax; [68Ga]Ga-DOTA-TATE; PET/CT; NET; SUVmax; [68Ga]Ga-DOTA-TATE; PET/CT; NET

Introduction – The maximum standardized uptake value (SUVmax) determination in Positron Emission Tomography (PET) with [68Ga] Ga-DOTA-TATE, allows the quantification of the density of somatostatin receptors, overexpressed by Neuroendocrine Tumors (NET). Related to the physiological and pathological pattern, the SUVmax analysis complements the visual assessment, yet this differentiation is controversial in the literature. The aim of this study was to evaluate the values of physiological and pathological SUVmax of [68Ga] Ga DOTA-TATE in different organs. Methods – This systematic review was carried out according to the guidelines of the checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA). Relevant articles were searched in PubMed, Scopus, and Web of Science, including the terms: SUVmax, PET/CT, [68Ga] Ga-DOTA-TATE, and NET. Articles where NET was studied by [68Ga] Ga DOTA-TATE PET/CT, using the SUVmax determination and presenting histological grade of the lesions were included. Descriptive statistics were used for data analysis. Results/Discussion – Physiological and pathological SUVmax values were collected from 20 articles included in the study. The lymph nodes, pituitary, pancreas, and liver were the organs that presented the greatest difference between physiological and pathological SUVmax, respectively: (1.1) and (6.0; 26.3), (2.0; 11.0) and (24.2), (3.5; 9.2) and (20.4; 87.6), and (6.5; 10.1) and (14.5; 40.0). The sample size and the inclusion of lesions with different grades may have influenced this segmentation. Conclusion – The average physiological and pathological SUVmax of [68Ga] Ga-DOTA-TATE is variable in different organs. Accordingly, by using this parameter it was possible to differentiate physiological and pathological uptake in organs such as lymph nodes, pancreas, pituitary, and GI tract.