Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test

Detalhes bibliográficos
Autor(a) principal: Fabbri, Margherita
Data de Publicação: 2017
Outros Autores: Coelho, Miguel, Guedes, Leonor Correia, Chendo, Inês, Sousa, Catarina, Rosa, Mario M., Abreu, Daisy, Costa, Nilza, Godinho, Catarina, Antonini, Angelo, Ferreira, Joaquim J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/29941
Resumo: Article under a CC-BY-NC-ND license - https://creativecommons.org/licenses/by-nc-nd/4.0/
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spelling Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge testParkinson's diseaseLate-stageLevodopaNon-motor symptomsArticle under a CC-BY-NC-ND license - https://creativecommons.org/licenses/by-nc-nd/4.0/"BACKGROUND: Non-motor symptoms (NMS) are extremely common among late-stage Parkinson's disease (LSPD) patients. Levodopa (L-dopa) responsiveness seems to decrease with disease progression but its effect on NMS in LSPD still needs to be investigated. OBJECTIVE: To assess the response of blood pressure (BP), pain, fatigue and anxiety to L-dopa in LSPD patients. METHODS: 20 LSPD patients, defined as Schwab and England ADL Scale <50 or Hoehn Yahr Stage >3 (MED ON) and 22 PD patients treated with subthalamic deep brain stimulation (advanced PD group) underwent an L-dopa challenge. BP and orthostatic hypotension (OH) assessment, a visual analogue scale (VAS) for pain and fatigue and the Strait Trait Anxiety (STAI) were evaluated before and after the L-dopa challenge. RESULTS: Systolic BP dropped significantly after L-dopa intake (p < 0.05) in LSPD patients, while there was no change in pain, fatigue or anxiety. L-dopa significantly improved (p < 0.05) pain and anxiety in the advanced PD group, whereas it had no effect on BP or fatigue. L-dopa-related adverse effects (AEs), namely OH and sleepiness, were more common among LSPD patients. 40% and 65% of LSPD patients were not able to fill out the VAS and the STAI, respectively, while measurement of orthostatic BP was not possible in four LSPD patients. CONCLUSIONS: This exploratory study concludes that some non-motor variables in LSPD do not benefit from the acute action of L-dopa while it can still induce disabling AEs. There is a need for assessment tools of NMS adapted to these disabled LSPD patients."ElsevierRepositório ComumFabbri, MargheritaCoelho, MiguelGuedes, Leonor CorreiaChendo, InêsSousa, CatarinaRosa, Mario M.Abreu, DaisyCosta, NilzaGodinho, CatarinaAntonini, AngeloFerreira, Joaquim J.2019-10-11T11:19:01Z2017-06-01T00:00:00Z2017-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/29941engParkinsonism Relat Disord. 2017 Jun;39:37-43. doi: 10.1016/j.parkreldis.2017.02.0071353-802010.1016/j.parkrelis.2017.02.007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:47Zoai:comum.rcaap.pt:10400.26/29941Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:34.442023Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
title Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
spellingShingle Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
Fabbri, Margherita
Parkinson's disease
Late-stage
Levodopa
Non-motor symptoms
title_short Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
title_full Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
title_fullStr Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
title_full_unstemmed Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
title_sort Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
author Fabbri, Margherita
author_facet Fabbri, Margherita
Coelho, Miguel
Guedes, Leonor Correia
Chendo, Inês
Sousa, Catarina
Rosa, Mario M.
Abreu, Daisy
Costa, Nilza
Godinho, Catarina
Antonini, Angelo
Ferreira, Joaquim J.
author_role author
author2 Coelho, Miguel
Guedes, Leonor Correia
Chendo, Inês
Sousa, Catarina
Rosa, Mario M.
Abreu, Daisy
Costa, Nilza
Godinho, Catarina
Antonini, Angelo
Ferreira, Joaquim J.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Fabbri, Margherita
Coelho, Miguel
Guedes, Leonor Correia
Chendo, Inês
Sousa, Catarina
Rosa, Mario M.
Abreu, Daisy
Costa, Nilza
Godinho, Catarina
Antonini, Angelo
Ferreira, Joaquim J.
dc.subject.por.fl_str_mv Parkinson's disease
Late-stage
Levodopa
Non-motor symptoms
topic Parkinson's disease
Late-stage
Levodopa
Non-motor symptoms
description Article under a CC-BY-NC-ND license - https://creativecommons.org/licenses/by-nc-nd/4.0/
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01T00:00:00Z
2017-06-01T00:00:00Z
2019-10-11T11:19:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/29941
url http://hdl.handle.net/10400.26/29941
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Parkinsonism Relat Disord. 2017 Jun;39:37-43. doi: 10.1016/j.parkreldis.2017.02.007
1353-8020
10.1016/j.parkrelis.2017.02.007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799129965841612800

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