Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.26/29905 |
Resumo: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Speech and voice response to a Levodopa challenge in late-stage Parkinson’s DiseaseParkinson’s diseaseLate stageLevodopaSpeechVoiceThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms."Background: Parkinson’s disease (PD) patients are affected by hypokinetic dysarthria, characterized by hypophonia and dysprosody, which worsens with disease progression. Levodopa’s (l-dopa) effect on quality of speech is inconclusive; no data are currently available for late-stage PD (LSPD). Objective: To assess the modifications of speech and voice in LSPD following an acute l-dopa challenge. Method: LSPD patients [Schwab and England score <50/Hoehn and Yahr stage >3 (MED ON)] performed several vocal tasks before and after an acute l-dopa challenge. The following was assessed: respiratory support for speech, voice quality, stability and variability, speech rate, and motor performance (MDS-UPDRS-III). All voice samples were recorded and analyzed by a speech and language therapist blinded to patients’ therapeutic condition using Praat 5.1 software. Results: 24/27 (14 men) LSPD patients succeeded in performing voice tasks. Median age and disease duration of patients were 79 [IQR: 71.5–81.7] and 14.5 [IQR: 11–15.7] years, respectively. In MED OFF, respiratory breath support and pitch break time of LSPD patients were worse than the normative values of non-parkinsonian. A correlation was found between disease duration and voice quality (R = 0.51; p = 0.013) and speech rate (R = −0.55; p = 0.008). l-Dopa significantly improved MDS-UPDRS-III score (20%), with no effect on speech as assessed by clinical rating scales and automated analysis. Conclusion: Speech is severely affected in LSPD. Although l-dopa had some effect on motor performance, including axial signs, speech and voice did not improve. The applicability and efficacy of non-pharmacological treatment for speech impairment should be considered for speech disorder management in PD."Frontiers MediaRepositório ComumFabbri, MargheritaGuimarães, IsabelCardoso, RitaCoelho, MiguelGuedes, Leonor CorreiaRosa, Maria M.Godinho, CatarinaAbreu, DaisyGonçalves, NilzaAntonini, AngeloFerreira, Joaquim J.2019-10-10T13:30:17Z2017-08-01T00:00:00Z2017-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/29905engFront Neurol. 2017 Aug 22;8:432. doi: 10.3389/fneur.2017.004321664-229510.3389/fneur.2017.00432info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:47Zoai:comum.rcaap.pt:10400.26/29905Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:34.243484Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease |
| title |
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease |
| spellingShingle |
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease Fabbri, Margherita Parkinson’s disease Late stage Levodopa Speech Voice |
| title_short |
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease |
| title_full |
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease |
| title_fullStr |
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease |
| title_full_unstemmed |
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease |
| title_sort |
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Disease |
| author |
Fabbri, Margherita |
| author_facet |
Fabbri, Margherita Guimarães, Isabel Cardoso, Rita Coelho, Miguel Guedes, Leonor Correia Rosa, Maria M. Godinho, Catarina Abreu, Daisy Gonçalves, Nilza Antonini, Angelo Ferreira, Joaquim J. |
| author_role |
author |
| author2 |
Guimarães, Isabel Cardoso, Rita Coelho, Miguel Guedes, Leonor Correia Rosa, Maria M. Godinho, Catarina Abreu, Daisy Gonçalves, Nilza Antonini, Angelo Ferreira, Joaquim J. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Comum |
| dc.contributor.author.fl_str_mv |
Fabbri, Margherita Guimarães, Isabel Cardoso, Rita Coelho, Miguel Guedes, Leonor Correia Rosa, Maria M. Godinho, Catarina Abreu, Daisy Gonçalves, Nilza Antonini, Angelo Ferreira, Joaquim J. |
| dc.subject.por.fl_str_mv |
Parkinson’s disease Late stage Levodopa Speech Voice |
| topic |
Parkinson’s disease Late stage Levodopa Speech Voice |
| description |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-08-01T00:00:00Z 2017-08-01T00:00:00Z 2019-10-10T13:30:17Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/29905 |
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http://hdl.handle.net/10400.26/29905 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Front Neurol. 2017 Aug 22;8:432. doi: 10.3389/fneur.2017.00432 1664-2295 10.3389/fneur.2017.00432 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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