The roadmap of RANKL/RANK pathway in cancer

Detalhes bibliográficos
Autor(a) principal: Casimiro, Sandra
Data de Publicação: 2021
Outros Autores: Vilhais, Guilherme, Fernandes Gomes, Inês, Costa, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54559
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling The roadmap of RANKL/RANK pathway in cancerRANK ligand (RANKL)Bone metastasisBone-targeted agentBreast cancerDrug repurposingReceptor activator of nuclear factor-κB (RANK)Targeted therapy© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The receptor activator of the nuclear factor-κB ligand (RANKL)/RANK signaling pathway was identified in the late 1990s and is the key mediator of bone remodeling. Targeting RANKL with the antibody denosumab is part of the standard of care for bone loss diseases, including bone metastases (BM). Over the last decade, evidence has implicated RANKL/RANK pathway in hormone and HER2-driven breast carcinogenesis and in the acquisition of molecular and phenotypic traits associated with breast cancer (BCa) aggressiveness and poor prognosis. This marked a new era in the research of the therapeutic use of RANKL inhibition in BCa. RANKL/RANK pathway is also an important immune mediator, with anti-RANKL therapy recently linked to improved response to immunotherapy in melanoma, non-small cell lung cancer (NSCLC), and renal cell carcinoma (RCC). This review summarizes and discusses the pre-clinical and clinical evidence of the relevance of the RANKL/RANK pathway in cancer biology and therapeutics, focusing on bone metastatic disease, BCa onset and progression, and immune modulation.This work was supported by the research project PTDC/MED-ONC/28636/2017 from Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado. IG is supported by the FCT PhD grant SFRH/BD/139178/2018.MDPIRepositório da Universidade de LisboaCasimiro, SandraVilhais, GuilhermeFernandes Gomes, InêsCosta, Luis2022-09-23T12:46:13Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54559engCells. 2021 Aug 4;10(8):197810.3390/cells100819782073-4409info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:00:59Zoai:repositorio.ul.pt:10451/54559Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:22.138249Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The roadmap of RANKL/RANK pathway in cancer
title The roadmap of RANKL/RANK pathway in cancer
spellingShingle The roadmap of RANKL/RANK pathway in cancer
Casimiro, Sandra
RANK ligand (RANKL)
Bone metastasis
Bone-targeted agent
Breast cancer
Drug repurposing
Receptor activator of nuclear factor-κB (RANK)
Targeted therapy
title_short The roadmap of RANKL/RANK pathway in cancer
title_full The roadmap of RANKL/RANK pathway in cancer
title_fullStr The roadmap of RANKL/RANK pathway in cancer
title_full_unstemmed The roadmap of RANKL/RANK pathway in cancer
title_sort The roadmap of RANKL/RANK pathway in cancer
author Casimiro, Sandra
author_facet Casimiro, Sandra
Vilhais, Guilherme
Fernandes Gomes, Inês
Costa, Luis
author_role author
author2 Vilhais, Guilherme
Fernandes Gomes, Inês
Costa, Luis
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Casimiro, Sandra
Vilhais, Guilherme
Fernandes Gomes, Inês
Costa, Luis
dc.subject.por.fl_str_mv RANK ligand (RANKL)
Bone metastasis
Bone-targeted agent
Breast cancer
Drug repurposing
Receptor activator of nuclear factor-κB (RANK)
Targeted therapy
topic RANK ligand (RANKL)
Bone metastasis
Bone-targeted agent
Breast cancer
Drug repurposing
Receptor activator of nuclear factor-κB (RANK)
Targeted therapy
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-09-23T12:46:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54559
url http://hdl.handle.net/10451/54559
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cells. 2021 Aug 4;10(8):1978
10.3390/cells10081978
2073-4409
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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