Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography

Detalhes bibliográficos
Autor(a) principal: Cabral, Diogo
Data de Publicação: 2022
Outros Autores: Fradinho, Ana C, Pereira, Telmo, Ramakrishnan, Meera S, Bacci, Tommaso, An, Dong, Tenreiro, Sandra, Seabra, Miguel C, Balaratnasingam, Chandrakumar, Freund, K Bailey
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/140993
Resumo: Funding: Supported by the Macula Foundation, Inc. (New York, NY, USA) and by Fundação para a Ciência e Tecnologia (FCT)–Portugal, cofunded by FEDER under the PT2020 Partnership Agreement (to MCS, including project PTDC/MED-PAT/30385/2017, iNOVA4Health-UIDB/04462/2020). ACF was funded by a FCT PhD studentship (PD/BD/135503/2018). DC was supported in part by a studentship from Fundação Luso-Americana para o Desenvolvimento (FLAD, USA R&D@PhD–Proj 2020/0140).
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spelling Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence TomographyCross-Sectional StudiesFluorescein Angiography/methodsHumansRetinal Vessels/diagnostic imagingTomography, Optical Coherence/methodsTomography, X-Ray ComputedVisual AcuitySDG 3 - Good Health and Well-beingFunding: Supported by the Macula Foundation, Inc. (New York, NY, USA) and by Fundação para a Ciência e Tecnologia (FCT)–Portugal, cofunded by FEDER under the PT2020 Partnership Agreement (to MCS, including project PTDC/MED-PAT/30385/2017, iNOVA4Health-UIDB/04462/2020). ACF was funded by a FCT PhD studentship (PD/BD/135503/2018). DC was supported in part by a studentship from Fundação Luso-Americana para o Desenvolvimento (FLAD, USA R&D@PhD–Proj 2020/0140).Purpose: To characterize macular blood flow connectivity in vivo using high-resolution optical coherence tomography (HighRes OCT). Methods: Cross-sectional, observational study. Dense (6-µm interscan distance) perifoveal HighRes OCT raster scans were performed on healthy participants. To mitigate the limitations of projection-resolved OCT-angiography, flow and structural data were used to observe the vascular structures of the superficial vascular complex (SVC) and the deep vascular complex. Vascular segmentation and rendering were performed using Imaris 9.5 software. Inflow and outflow patterns were classified according to vascular diameter and branching order from superficial arteries and veins, respectively. Results: Eight eyes from eight participants were included in this analysis, from which 422 inflow and 459 outflow connections were characterized. Arteries had direct arteriolar connections to the SVC (78%) and to the intermediate capillary plexus (ICP, 22%). Deep capillary plexus (DCP) inflow derived from small-diameter vessels succeeding ICP arterioles. The most prevalent outflow pathways coursed through superficial draining venules (74%). DCP draining venules ordinarily merged with ICP draining venules and drained independently of superficial venules in 21% of cases. The morphology of DCP draining venules in structural HighRes OCT is distinct from other vessels crossing the inner nuclear layer and can be used to identify superficial veins. Conclusions: Vascular connectivity analysis supports a hybrid circuitry of blood flow within the human parafoveal macula. Translational Relevance: Characterization of parafoveal macular blood flow connectivity in vivo using a precise segmentation of HighRes OCT is consistent with ground-truth microscopy studies and shows a hybrid circuitry.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCabral, DiogoFradinho, Ana CPereira, TelmoRamakrishnan, Meera SBacci, TommasoAn, DongTenreiro, SandraSeabra, Miguel CBalaratnasingam, ChandrakumarFreund, K Bailey2022-06-28T22:27:46Z2022-06-012022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/140993eng2164-2591PURE: 45002113https://doi.org/10.1167/tvst.11.6.2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:18:14Zoai:run.unl.pt:10362/140993Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:49:52.854630Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
title Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
spellingShingle Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
Cabral, Diogo
Cross-Sectional Studies
Fluorescein Angiography/methods
Humans
Retinal Vessels/diagnostic imaging
Tomography, Optical Coherence/methods
Tomography, X-Ray Computed
Visual Acuity
SDG 3 - Good Health and Well-being
title_short Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
title_full Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
title_fullStr Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
title_full_unstemmed Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
title_sort Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
author Cabral, Diogo
author_facet Cabral, Diogo
Fradinho, Ana C
Pereira, Telmo
Ramakrishnan, Meera S
Bacci, Tommaso
An, Dong
Tenreiro, Sandra
Seabra, Miguel C
Balaratnasingam, Chandrakumar
Freund, K Bailey
author_role author
author2 Fradinho, Ana C
Pereira, Telmo
Ramakrishnan, Meera S
Bacci, Tommaso
An, Dong
Tenreiro, Sandra
Seabra, Miguel C
Balaratnasingam, Chandrakumar
Freund, K Bailey
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Cabral, Diogo
Fradinho, Ana C
Pereira, Telmo
Ramakrishnan, Meera S
Bacci, Tommaso
An, Dong
Tenreiro, Sandra
Seabra, Miguel C
Balaratnasingam, Chandrakumar
Freund, K Bailey
dc.subject.por.fl_str_mv Cross-Sectional Studies
Fluorescein Angiography/methods
Humans
Retinal Vessels/diagnostic imaging
Tomography, Optical Coherence/methods
Tomography, X-Ray Computed
Visual Acuity
SDG 3 - Good Health and Well-being
topic Cross-Sectional Studies
Fluorescein Angiography/methods
Humans
Retinal Vessels/diagnostic imaging
Tomography, Optical Coherence/methods
Tomography, X-Ray Computed
Visual Acuity
SDG 3 - Good Health and Well-being
description Funding: Supported by the Macula Foundation, Inc. (New York, NY, USA) and by Fundação para a Ciência e Tecnologia (FCT)–Portugal, cofunded by FEDER under the PT2020 Partnership Agreement (to MCS, including project PTDC/MED-PAT/30385/2017, iNOVA4Health-UIDB/04462/2020). ACF was funded by a FCT PhD studentship (PD/BD/135503/2018). DC was supported in part by a studentship from Fundação Luso-Americana para o Desenvolvimento (FLAD, USA R&D@PhD–Proj 2020/0140).
publishDate 2022
dc.date.none.fl_str_mv 2022-06-28T22:27:46Z
2022-06-01
2022-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/140993
url http://hdl.handle.net/10362/140993
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2164-2591
PURE: 45002113
https://doi.org/10.1167/tvst.11.6.2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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