Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/140993 |
Resumo: | Funding: Supported by the Macula Foundation, Inc. (New York, NY, USA) and by Fundação para a Ciência e Tecnologia (FCT)–Portugal, cofunded by FEDER under the PT2020 Partnership Agreement (to MCS, including project PTDC/MED-PAT/30385/2017, iNOVA4Health-UIDB/04462/2020). ACF was funded by a FCT PhD studentship (PD/BD/135503/2018). DC was supported in part by a studentship from Fundação Luso-Americana para o Desenvolvimento (FLAD, USA R&D@PhD–Proj 2020/0140). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence TomographyCross-Sectional StudiesFluorescein Angiography/methodsHumansRetinal Vessels/diagnostic imagingTomography, Optical Coherence/methodsTomography, X-Ray ComputedVisual AcuitySDG 3 - Good Health and Well-beingFunding: Supported by the Macula Foundation, Inc. (New York, NY, USA) and by Fundação para a Ciência e Tecnologia (FCT)–Portugal, cofunded by FEDER under the PT2020 Partnership Agreement (to MCS, including project PTDC/MED-PAT/30385/2017, iNOVA4Health-UIDB/04462/2020). ACF was funded by a FCT PhD studentship (PD/BD/135503/2018). DC was supported in part by a studentship from Fundação Luso-Americana para o Desenvolvimento (FLAD, USA R&D@PhD–Proj 2020/0140).Purpose: To characterize macular blood flow connectivity in vivo using high-resolution optical coherence tomography (HighRes OCT). Methods: Cross-sectional, observational study. Dense (6-µm interscan distance) perifoveal HighRes OCT raster scans were performed on healthy participants. To mitigate the limitations of projection-resolved OCT-angiography, flow and structural data were used to observe the vascular structures of the superficial vascular complex (SVC) and the deep vascular complex. Vascular segmentation and rendering were performed using Imaris 9.5 software. Inflow and outflow patterns were classified according to vascular diameter and branching order from superficial arteries and veins, respectively. Results: Eight eyes from eight participants were included in this analysis, from which 422 inflow and 459 outflow connections were characterized. Arteries had direct arteriolar connections to the SVC (78%) and to the intermediate capillary plexus (ICP, 22%). Deep capillary plexus (DCP) inflow derived from small-diameter vessels succeeding ICP arterioles. The most prevalent outflow pathways coursed through superficial draining venules (74%). DCP draining venules ordinarily merged with ICP draining venules and drained independently of superficial venules in 21% of cases. The morphology of DCP draining venules in structural HighRes OCT is distinct from other vessels crossing the inner nuclear layer and can be used to identify superficial veins. Conclusions: Vascular connectivity analysis supports a hybrid circuitry of blood flow within the human parafoveal macula. Translational Relevance: Characterization of parafoveal macular blood flow connectivity in vivo using a precise segmentation of HighRes OCT is consistent with ground-truth microscopy studies and shows a hybrid circuitry.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCabral, DiogoFradinho, Ana CPereira, TelmoRamakrishnan, Meera SBacci, TommasoAn, DongTenreiro, SandraSeabra, Miguel CBalaratnasingam, ChandrakumarFreund, K Bailey2022-06-28T22:27:46Z2022-06-012022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/140993eng2164-2591PURE: 45002113https://doi.org/10.1167/tvst.11.6.2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:18:14Zoai:run.unl.pt:10362/140993Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:49:52.854630Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography |
title |
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography |
spellingShingle |
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography Cabral, Diogo Cross-Sectional Studies Fluorescein Angiography/methods Humans Retinal Vessels/diagnostic imaging Tomography, Optical Coherence/methods Tomography, X-Ray Computed Visual Acuity SDG 3 - Good Health and Well-being |
title_short |
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography |
title_full |
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography |
title_fullStr |
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography |
title_full_unstemmed |
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography |
title_sort |
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography |
author |
Cabral, Diogo |
author_facet |
Cabral, Diogo Fradinho, Ana C Pereira, Telmo Ramakrishnan, Meera S Bacci, Tommaso An, Dong Tenreiro, Sandra Seabra, Miguel C Balaratnasingam, Chandrakumar Freund, K Bailey |
author_role |
author |
author2 |
Fradinho, Ana C Pereira, Telmo Ramakrishnan, Meera S Bacci, Tommaso An, Dong Tenreiro, Sandra Seabra, Miguel C Balaratnasingam, Chandrakumar Freund, K Bailey |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Cabral, Diogo Fradinho, Ana C Pereira, Telmo Ramakrishnan, Meera S Bacci, Tommaso An, Dong Tenreiro, Sandra Seabra, Miguel C Balaratnasingam, Chandrakumar Freund, K Bailey |
dc.subject.por.fl_str_mv |
Cross-Sectional Studies Fluorescein Angiography/methods Humans Retinal Vessels/diagnostic imaging Tomography, Optical Coherence/methods Tomography, X-Ray Computed Visual Acuity SDG 3 - Good Health and Well-being |
topic |
Cross-Sectional Studies Fluorescein Angiography/methods Humans Retinal Vessels/diagnostic imaging Tomography, Optical Coherence/methods Tomography, X-Ray Computed Visual Acuity SDG 3 - Good Health and Well-being |
description |
Funding: Supported by the Macula Foundation, Inc. (New York, NY, USA) and by Fundação para a Ciência e Tecnologia (FCT)–Portugal, cofunded by FEDER under the PT2020 Partnership Agreement (to MCS, including project PTDC/MED-PAT/30385/2017, iNOVA4Health-UIDB/04462/2020). ACF was funded by a FCT PhD studentship (PD/BD/135503/2018). DC was supported in part by a studentship from Fundação Luso-Americana para o Desenvolvimento (FLAD, USA R&D@PhD–Proj 2020/0140). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-28T22:27:46Z 2022-06-01 2022-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/140993 |
url |
http://hdl.handle.net/10362/140993 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2164-2591 PURE: 45002113 https://doi.org/10.1167/tvst.11.6.2 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138096524034048 |