Methimazole associated eosinophilic pleural effusion: a case report

Detalhes bibliográficos
Autor(a) principal: Gaspar da Costa, Pedro
Data de Publicação: 2017
Outros Autores: Duarte Silva, Filipa, Henriques, Júlia, Vale, Sónia do, Braz, Sandra, Meneses Santos, João, M.M. Victorino, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/45190
Resumo: © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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spelling Methimazole associated eosinophilic pleural effusion: a case reportEosinophilic pleural effusionThionamidesMethimazoleHypersensitivity reactionCase report© The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: Adverse reactions associated to anti-thyroid drugs include fever, rash, arthralgia, agranulocytosis and hepatitis that are thought to be hypersensitivity reactions. Five cases of pleural effusion associated to thionamides have also been reported, two with propylthiouracil and three with carbimazole. Case presentation: We report here a case of a 75-year-old man admitted because of unilateral pleural effusion. The patient had a recent diagnosis of hyperthyroidism and 6 days after starting methimazole complained of pleuritic chest pain. He had elevated C-reactive protein and erythrocyte sedimentation rate and normal white blood cell count and liver enzymes. Chest radiography showed a moderate right pleural effusion and the ultrasound revealed a loculated effusion that was shown to be an eosinophilic exudate. Conclusions: The temporal relationship between methimazole intake and the development of pleural effusion combined with the extensive exclusion of alternative causes, namely infectious, neoplastic and primary auto-immune diseases, led to the diagnosis of hypersensitivity reaction to methimazole. The thionamide was stopped and corticosteroid was started with complete resolution of the pleural effusion in 3 months. Awareness of this rare adverse reaction of anti-thyroid drugs is important and methimazole can be added to the list of possible etiologies of drug-induced eosinophilic pleural effusion.BioMed Central Ltd.Repositório da Universidade de LisboaGaspar da Costa, PedroDuarte Silva, FilipaHenriques, JúliaVale, Sónia doBraz, SandraMeneses Santos, JoãoM.M. Victorino, Rui2020-12-09T14:26:06Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45190engBMC Pharmacol Toxicol. 2017 Mar 21;18(1):1610.1186/s40360-017-0121-12050-6511info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:46:49Zoai:repositorio.ul.pt:10451/45190Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:57:41.362360Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Methimazole associated eosinophilic pleural effusion: a case report
title Methimazole associated eosinophilic pleural effusion: a case report
spellingShingle Methimazole associated eosinophilic pleural effusion: a case report
Gaspar da Costa, Pedro
Eosinophilic pleural effusion
Thionamides
Methimazole
Hypersensitivity reaction
Case report
title_short Methimazole associated eosinophilic pleural effusion: a case report
title_full Methimazole associated eosinophilic pleural effusion: a case report
title_fullStr Methimazole associated eosinophilic pleural effusion: a case report
title_full_unstemmed Methimazole associated eosinophilic pleural effusion: a case report
title_sort Methimazole associated eosinophilic pleural effusion: a case report
author Gaspar da Costa, Pedro
author_facet Gaspar da Costa, Pedro
Duarte Silva, Filipa
Henriques, Júlia
Vale, Sónia do
Braz, Sandra
Meneses Santos, João
M.M. Victorino, Rui
author_role author
author2 Duarte Silva, Filipa
Henriques, Júlia
Vale, Sónia do
Braz, Sandra
Meneses Santos, João
M.M. Victorino, Rui
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gaspar da Costa, Pedro
Duarte Silva, Filipa
Henriques, Júlia
Vale, Sónia do
Braz, Sandra
Meneses Santos, João
M.M. Victorino, Rui
dc.subject.por.fl_str_mv Eosinophilic pleural effusion
Thionamides
Methimazole
Hypersensitivity reaction
Case report
topic Eosinophilic pleural effusion
Thionamides
Methimazole
Hypersensitivity reaction
Case report
description © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2020-12-09T14:26:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/45190
url http://hdl.handle.net/10451/45190
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Pharmacol Toxicol. 2017 Mar 21;18(1):16
10.1186/s40360-017-0121-1
2050-6511
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central Ltd.
publisher.none.fl_str_mv BioMed Central Ltd.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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