Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering

Detalhes bibliográficos
Autor(a) principal: Monteiro, Nelson
Data de Publicação: 2015
Outros Autores: Martins, Albino, Reis, R. L., Neves, N. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/38399
Resumo: The inability to deliver bioactive agents locally in a transient but sustained manner is one of the challenges on the development of bio-functionalized scaffolds for tissue engineering (TE) and regenerative medicine. The mode of release is especially relevant when the bioactive agent is a growth factor (GF), because the dose and the spatiotemporal release of such agents at the site of injury are crucial to achieve a successful outcome. Strategies that combine scaffolds and drug delivery systems have the potential to provide more effective tissue regeneration relative to current therapies. Nanoparticles (NPs) can protect the bioactive agents, control its profile, decrease the occurrence and severity of side effects and deliver the bioactive agent to the target cells maximizing its effect. Scaffolds containing NPs loaded with bioactive agents can be used for their local delivery, enabling site-specific pharmacological effects such as the induction of cell proliferation and differentiation, and, consequently, neo-tissue formation. This review aims to describe the concept of combining NPs with scaffolds, and the current efforts aiming to develop highly multi-functional bioactive agent release systems, with the emphasis on their application in TE of connective tissues.
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spelling Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineeringBioactive agentsDelivery systemsMesenchymal stem cellsNanoparticlesScaffoldsCiências Médicas::Biotecnologia MédicaScience & TechnologyThe inability to deliver bioactive agents locally in a transient but sustained manner is one of the challenges on the development of bio-functionalized scaffolds for tissue engineering (TE) and regenerative medicine. The mode of release is especially relevant when the bioactive agent is a growth factor (GF), because the dose and the spatiotemporal release of such agents at the site of injury are crucial to achieve a successful outcome. Strategies that combine scaffolds and drug delivery systems have the potential to provide more effective tissue regeneration relative to current therapies. Nanoparticles (NPs) can protect the bioactive agents, control its profile, decrease the occurrence and severity of side effects and deliver the bioactive agent to the target cells maximizing its effect. Scaffolds containing NPs loaded with bioactive agents can be used for their local delivery, enabling site-specific pharmacological effects such as the induction of cell proliferation and differentiation, and, consequently, neo-tissue formation. This review aims to describe the concept of combining NPs with scaffolds, and the current efforts aiming to develop highly multi-functional bioactive agent release systems, with the emphasis on their application in TE of connective tissues.POLARIS (REGPOT-CT2012-316331-POLARIS), RL3 – TECT – NORTE-01-0124-FEDER-000020, co-financed by North Portugal Regional Operational Programme (ON.2 – O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF), the OsteoGraphy (PTDC/EME-MFE/2008) and MaxBone (PTDC/SAU-ENB/115179/2009) projectsElsevierUniversidade do MinhoMonteiro, NelsonMartins, AlbinoReis, R. L.Neves, N. M.2015-062015-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/38399engMonteiro N., Martins A., Reis R. L., Neves N. M. Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering, Regenerative Therapy, Vol. 1, pp. 109–118, doi:doi:10.1016/j.reth.2015.05.004, 20152352-320410.1016/j.reth.2015.05.004http://www.sciencedirect.com/science/article/pii/S235232041500019Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:44:46Zoai:repositorium.sdum.uminho.pt:1822/38399Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:42:31.745867Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
title Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
spellingShingle Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
Monteiro, Nelson
Bioactive agents
Delivery systems
Mesenchymal stem cells
Nanoparticles
Scaffolds
Ciências Médicas::Biotecnologia Médica
Science & Technology
title_short Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
title_full Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
title_fullStr Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
title_full_unstemmed Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
title_sort Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
author Monteiro, Nelson
author_facet Monteiro, Nelson
Martins, Albino
Reis, R. L.
Neves, N. M.
author_role author
author2 Martins, Albino
Reis, R. L.
Neves, N. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Monteiro, Nelson
Martins, Albino
Reis, R. L.
Neves, N. M.
dc.subject.por.fl_str_mv Bioactive agents
Delivery systems
Mesenchymal stem cells
Nanoparticles
Scaffolds
Ciências Médicas::Biotecnologia Médica
Science & Technology
topic Bioactive agents
Delivery systems
Mesenchymal stem cells
Nanoparticles
Scaffolds
Ciências Médicas::Biotecnologia Médica
Science & Technology
description The inability to deliver bioactive agents locally in a transient but sustained manner is one of the challenges on the development of bio-functionalized scaffolds for tissue engineering (TE) and regenerative medicine. The mode of release is especially relevant when the bioactive agent is a growth factor (GF), because the dose and the spatiotemporal release of such agents at the site of injury are crucial to achieve a successful outcome. Strategies that combine scaffolds and drug delivery systems have the potential to provide more effective tissue regeneration relative to current therapies. Nanoparticles (NPs) can protect the bioactive agents, control its profile, decrease the occurrence and severity of side effects and deliver the bioactive agent to the target cells maximizing its effect. Scaffolds containing NPs loaded with bioactive agents can be used for their local delivery, enabling site-specific pharmacological effects such as the induction of cell proliferation and differentiation, and, consequently, neo-tissue formation. This review aims to describe the concept of combining NPs with scaffolds, and the current efforts aiming to develop highly multi-functional bioactive agent release systems, with the emphasis on their application in TE of connective tissues.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
2015-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/38399
url http://hdl.handle.net/1822/38399
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Monteiro N., Martins A., Reis R. L., Neves N. M. Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering, Regenerative Therapy, Vol. 1, pp. 109–118, doi:doi:10.1016/j.reth.2015.05.004, 2015
2352-3204
10.1016/j.reth.2015.05.004
http://www.sciencedirect.com/science/article/pii/S235232041500019X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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