Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6

Detalhes bibliográficos
Autor(a) principal: Simões, Inês Tadeu dos Anjos
Data de Publicação: 2011
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/6582
Resumo: Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina
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spelling Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6Scavenger receptor cysteine-rich receptorsCD5/CD6 lymphocyte receptorsTransgenic miceTumor modelsImmunomodulationDissertação para obtenção do Grau de Mestre em Genética Molecular e BiomedicinaThe CD5 and CD6 lymphocyte surface receptors are highly homologous members of the Scavenger Receptor Cystein Rich (SRCR) superfamily mainly expressed by all T lymphocytes and the B1a subpopulation of B cells. Although the ultimate function/s are far from being completely understood, CD5 and CD6 are known to play a relevant role in both lymphocyte development and differentiation by negatively modulating the survival/death-inducing intracellular signals generated during the antigen recognition. Recently, this group has developed a transgenic mouse line which expresses a soluble form of human CD5, likely blocking the ligand-receptor interactions mediated by CD5 and interfering with normal lymphocyte response. This study was aimed at furthering the study of the recombinant soluble human CD5 Transgenic(rshCD5Tg) mouse phenotypical analysis, its response to antigen stimuli and tumor implantation; the function of rshCD6 was also tested. It was observed that rshCD5Tg mice display an exacerbated immune response, likely due to a reduction in the number of T and B cells with regulatory/suppressive function (Treg, B1a, B10 cells) and the increase in effector cells (NKT, MZ B cells). In agreement with these phenotypical characteristics, the functional analysis of rshCD5Tg mice showed enhanced immune responses to Tdependent and –independent antigens, as well as enhanced anti-tumoral responses, with or without concomitant chemotherapy treatment. Importantly, both the phenotypical and functional findings could be reproduced in wild-type mice following prolonged infusion of purified exogenous rshCD5 protein. Overall, these results argue in favor of a relevant role of CD5-mediated molecular interactions in the homeostasis of functionally relevant lymphocyte subpopulations and open the possibility for CD5-based therapeutical interventions in different disease settings such as cancer, infection and immunodeficiency.Faculdade de Ciências e TecnologiaLozano, FranciscoMartinez, VanesaLudovice, Ana MadalenaRUNSimões, Inês Tadeu dos Anjos2011-12-28T16:37:22Z20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/6582enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T03:37:41Zoai:run.unl.pt:10362/6582Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:16:53.107453Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6
title Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6
spellingShingle Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6
Simões, Inês Tadeu dos Anjos
Scavenger receptor cysteine-rich receptors
CD5/CD6 lymphocyte receptors
Transgenic mice
Tumor models
Immunomodulation
title_short Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6
title_full Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6
title_fullStr Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6
title_full_unstemmed Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6
title_sort Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6
author Simões, Inês Tadeu dos Anjos
author_facet Simões, Inês Tadeu dos Anjos
author_role author
dc.contributor.none.fl_str_mv Lozano, Francisco
Martinez, Vanesa
Ludovice, Ana Madalena
RUN
dc.contributor.author.fl_str_mv Simões, Inês Tadeu dos Anjos
dc.subject.por.fl_str_mv Scavenger receptor cysteine-rich receptors
CD5/CD6 lymphocyte receptors
Transgenic mice
Tumor models
Immunomodulation
topic Scavenger receptor cysteine-rich receptors
CD5/CD6 lymphocyte receptors
Transgenic mice
Tumor models
Immunomodulation
description Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina
publishDate 2011
dc.date.none.fl_str_mv 2011-12-28T16:37:22Z
2011
2011-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/6582
url http://hdl.handle.net/10362/6582
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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