Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis

Detalhes bibliográficos
Autor(a) principal: Pombinho, R
Data de Publicação: 2018
Outros Autores: Sousa, S, Cabanes, D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://repositorio-aberto.up.pt/handle/10216/118485
Resumo: Innate immunity is the most broadly effective host defense, being essential to clear the majority of microbial infections. Scavenger Receptors comprise a family of sensors expressed in a multitude of host cells, whose dual role during microbial pathogenesis gained importance over recent years. SRs regulate the recruitment of immune cells and control both host inflammatory response and bacterial load. In turn, pathogens have evolved different strategies to overcome immune response, avoid recognition by SRs and exploit them to favor infection. Here, we discuss the most relevant findings regarding the interplay between SRs and pathogens, discussing how these multifunctional proteins recognize a panoply of ligands and act as bacterial phagocytic receptors.
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spelling Scavenger Receptors: Promiscuous Players during Microbial PathogenesisInnate immune responseMicrobial pathogenesisPathogensScavenger receptorsInnate immunity is the most broadly effective host defense, being essential to clear the majority of microbial infections. Scavenger Receptors comprise a family of sensors expressed in a multitude of host cells, whose dual role during microbial pathogenesis gained importance over recent years. SRs regulate the recruitment of immune cells and control both host inflammatory response and bacterial load. In turn, pathogens have evolved different strategies to overcome immune response, avoid recognition by SRs and exploit them to favor infection. Here, we discuss the most relevant findings regarding the interplay between SRs and pathogens, discussing how these multifunctional proteins recognize a panoply of ligands and act as bacterial phagocytic receptors.CRC Press2018-11-302018-11-30T00:00:00Z2019-11-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/118485eng1040-841X10.1080/1040841X.2018.1493716Pombinho, RSousa, SCabanes, Dinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:28:04Zoai:repositorio-aberto.up.pt:10216/118485Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:41:04.925797Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis
title Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis
spellingShingle Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis
Pombinho, R
Innate immune response
Microbial pathogenesis
Pathogens
Scavenger receptors
title_short Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis
title_full Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis
title_fullStr Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis
title_full_unstemmed Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis
title_sort Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis
author Pombinho, R
author_facet Pombinho, R
Sousa, S
Cabanes, D
author_role author
author2 Sousa, S
Cabanes, D
author2_role author
author
dc.contributor.author.fl_str_mv Pombinho, R
Sousa, S
Cabanes, D
dc.subject.por.fl_str_mv Innate immune response
Microbial pathogenesis
Pathogens
Scavenger receptors
topic Innate immune response
Microbial pathogenesis
Pathogens
Scavenger receptors
description Innate immunity is the most broadly effective host defense, being essential to clear the majority of microbial infections. Scavenger Receptors comprise a family of sensors expressed in a multitude of host cells, whose dual role during microbial pathogenesis gained importance over recent years. SRs regulate the recruitment of immune cells and control both host inflammatory response and bacterial load. In turn, pathogens have evolved different strategies to overcome immune response, avoid recognition by SRs and exploit them to favor infection. Here, we discuss the most relevant findings regarding the interplay between SRs and pathogens, discussing how these multifunctional proteins recognize a panoply of ligands and act as bacterial phagocytic receptors.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-30
2018-11-30T00:00:00Z
2019-11-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/118485
url https://repositorio-aberto.up.pt/handle/10216/118485
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1040-841X
10.1080/1040841X.2018.1493716
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv CRC Press
publisher.none.fl_str_mv CRC Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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