COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?

Detalhes bibliográficos
Autor(a) principal: Zoppi, Roberta
Data de Publicação: 2020
Outros Autores: Deschepper, Fanny, Santos, Lucio Lara, Videira, Paula Alexandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.34635/rpc.816
Resumo: Colorectal cancer remains the second deadliest type of cancer with many causes resulting in a severe outcome. It is well recognized the higher level of cellular heterogeneity of colorectal cancer respect to any other type of cancer, which plays a significant role in its diagnosis, prognosis and treatment. Colorectal cancer is a curable disease when detected in early phases, up to 90% when detected in stage I, but the absence of symptoms makes the diagnosis a problematic process. Thus, the understanding of the tumour dynamics, cancer genetics and the expression of specific tumour biomarkers is crucial for the cancer early detection. Furthermore, parallel studies demonstrated the determinant role of post-translational modification in cancer formation and progression. This review aims to resume and combine all the different aspects involved in colorectal cancer malignancy, important for clinicians and researchers to understand where we currently stand, and which improvements are required. 
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spelling COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?CANCRO COLORETAL ENTRE A APLICAÇÃO CLÍNICA E A INVESTIGAÇÃO TRANSLACIONAL – ONDE ESTAMOS E O QUE PODE SER MELHORADO?Colorectal cancer remains the second deadliest type of cancer with many causes resulting in a severe outcome. It is well recognized the higher level of cellular heterogeneity of colorectal cancer respect to any other type of cancer, which plays a significant role in its diagnosis, prognosis and treatment. Colorectal cancer is a curable disease when detected in early phases, up to 90% when detected in stage I, but the absence of symptoms makes the diagnosis a problematic process. Thus, the understanding of the tumour dynamics, cancer genetics and the expression of specific tumour biomarkers is crucial for the cancer early detection. Furthermore, parallel studies demonstrated the determinant role of post-translational modification in cancer formation and progression. This review aims to resume and combine all the different aspects involved in colorectal cancer malignancy, important for clinicians and researchers to understand where we currently stand, and which improvements are required. O Cancro colorectal é o segundo tipo de cancro mais mortal. A heterogeneidade celular deste tumor tem impacto no diagnóstico, no tratamento e prognóstico. Este tumor maligno é curável quando diagnosticado em fase inicial, e a sobrevivencia é longa (90% aos 5 anos) quando diagnosticado no estágio I, mas a ausência de sintomas torna por vezes o diagnóstico difícil. Assim, o conhecimento da biologia tumoral, da genética e a expressão de biomarcadores tumorais específicos deste tumor malign são fundamentais para protocolos de detecção mais precoces. Estudos paralelos demonstraram o papel determinante das modificações pós-transcripcionais na carcinogénese e progressão do canco colorectal. A presente revisão tem como objetivo resumir e associar os diferentes aspectos biológicos envolvidos nos distintos perfis desta neoplasia maligna, importantes na decisão médica. Pretendemos dar uma visão o que os investigadores já sabem e o que é necessário ainda fazer e conhecer. Sociedade Portuguesa de Cirurgia2020-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.34635/rpc.816https://doi.org/10.34635/rpc.816Revista Portuguesa de Cirurgia; No 48 (2020): Number 48 - September 2020; 65-80Revista Portuguesa de Cirurgia; No 48 (2020): Number 48 - September 2020; 65-802183-11651646-6918reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spcir.com/index.php/spcir/article/view/816https://revista.spcir.com/index.php/spcir/article/view/816/564Copyright (c) 2020 Revista Portuguesa de Cirurgiainfo:eu-repo/semantics/openAccessZoppi, RobertaDeschepper, FannySantos, Lucio LaraVideira, Paula Alexandra2024-03-14T22:04:36Zoai:revista.spcir.com:article/816Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:40.030750Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
CANCRO COLORETAL ENTRE A APLICAÇÃO CLÍNICA E A INVESTIGAÇÃO TRANSLACIONAL – ONDE ESTAMOS E O QUE PODE SER MELHORADO?
title COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
spellingShingle COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
Zoppi, Roberta
title_short COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
title_full COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
title_fullStr COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
title_full_unstemmed COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
title_sort COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
author Zoppi, Roberta
author_facet Zoppi, Roberta
Deschepper, Fanny
Santos, Lucio Lara
Videira, Paula Alexandra
author_role author
author2 Deschepper, Fanny
Santos, Lucio Lara
Videira, Paula Alexandra
author2_role author
author
author
dc.contributor.author.fl_str_mv Zoppi, Roberta
Deschepper, Fanny
Santos, Lucio Lara
Videira, Paula Alexandra
description Colorectal cancer remains the second deadliest type of cancer with many causes resulting in a severe outcome. It is well recognized the higher level of cellular heterogeneity of colorectal cancer respect to any other type of cancer, which plays a significant role in its diagnosis, prognosis and treatment. Colorectal cancer is a curable disease when detected in early phases, up to 90% when detected in stage I, but the absence of symptoms makes the diagnosis a problematic process. Thus, the understanding of the tumour dynamics, cancer genetics and the expression of specific tumour biomarkers is crucial for the cancer early detection. Furthermore, parallel studies demonstrated the determinant role of post-translational modification in cancer formation and progression. This review aims to resume and combine all the different aspects involved in colorectal cancer malignancy, important for clinicians and researchers to understand where we currently stand, and which improvements are required. 
publishDate 2020
dc.date.none.fl_str_mv 2020-09-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.34635/rpc.816
https://doi.org/10.34635/rpc.816
url https://doi.org/10.34635/rpc.816
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revista.spcir.com/index.php/spcir/article/view/816
https://revista.spcir.com/index.php/spcir/article/view/816/564
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista Portuguesa de Cirurgia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista Portuguesa de Cirurgia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Cirurgia
publisher.none.fl_str_mv Sociedade Portuguesa de Cirurgia
dc.source.none.fl_str_mv Revista Portuguesa de Cirurgia; No 48 (2020): Number 48 - September 2020; 65-80
Revista Portuguesa de Cirurgia; No 48 (2020): Number 48 - September 2020; 65-80
2183-1165
1646-6918
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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