COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.34635/rpc.816 |
Resumo: | Colorectal cancer remains the second deadliest type of cancer with many causes resulting in a severe outcome. It is well recognized the higher level of cellular heterogeneity of colorectal cancer respect to any other type of cancer, which plays a significant role in its diagnosis, prognosis and treatment. Colorectal cancer is a curable disease when detected in early phases, up to 90% when detected in stage I, but the absence of symptoms makes the diagnosis a problematic process. Thus, the understanding of the tumour dynamics, cancer genetics and the expression of specific tumour biomarkers is crucial for the cancer early detection. Furthermore, parallel studies demonstrated the determinant role of post-translational modification in cancer formation and progression. This review aims to resume and combine all the different aspects involved in colorectal cancer malignancy, important for clinicians and researchers to understand where we currently stand, and which improvements are required. |
id |
RCAP_889faf6336a14f4ec86a4f9016f8814d |
---|---|
oai_identifier_str |
oai:revista.spcir.com:article/816 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED?CANCRO COLORETAL ENTRE A APLICAÇÃO CLÍNICA E A INVESTIGAÇÃO TRANSLACIONAL – ONDE ESTAMOS E O QUE PODE SER MELHORADO?Colorectal cancer remains the second deadliest type of cancer with many causes resulting in a severe outcome. It is well recognized the higher level of cellular heterogeneity of colorectal cancer respect to any other type of cancer, which plays a significant role in its diagnosis, prognosis and treatment. Colorectal cancer is a curable disease when detected in early phases, up to 90% when detected in stage I, but the absence of symptoms makes the diagnosis a problematic process. Thus, the understanding of the tumour dynamics, cancer genetics and the expression of specific tumour biomarkers is crucial for the cancer early detection. Furthermore, parallel studies demonstrated the determinant role of post-translational modification in cancer formation and progression. This review aims to resume and combine all the different aspects involved in colorectal cancer malignancy, important for clinicians and researchers to understand where we currently stand, and which improvements are required. O Cancro colorectal é o segundo tipo de cancro mais mortal. A heterogeneidade celular deste tumor tem impacto no diagnóstico, no tratamento e prognóstico. Este tumor maligno é curável quando diagnosticado em fase inicial, e a sobrevivencia é longa (90% aos 5 anos) quando diagnosticado no estágio I, mas a ausência de sintomas torna por vezes o diagnóstico difícil. Assim, o conhecimento da biologia tumoral, da genética e a expressão de biomarcadores tumorais específicos deste tumor malign são fundamentais para protocolos de detecção mais precoces. Estudos paralelos demonstraram o papel determinante das modificações pós-transcripcionais na carcinogénese e progressão do canco colorectal. A presente revisão tem como objetivo resumir e associar os diferentes aspectos biológicos envolvidos nos distintos perfis desta neoplasia maligna, importantes na decisão médica. Pretendemos dar uma visão o que os investigadores já sabem e o que é necessário ainda fazer e conhecer. Sociedade Portuguesa de Cirurgia2020-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.34635/rpc.816https://doi.org/10.34635/rpc.816Revista Portuguesa de Cirurgia; No 48 (2020): Number 48 - September 2020; 65-80Revista Portuguesa de Cirurgia; No 48 (2020): Number 48 - September 2020; 65-802183-11651646-6918reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spcir.com/index.php/spcir/article/view/816https://revista.spcir.com/index.php/spcir/article/view/816/564Copyright (c) 2020 Revista Portuguesa de Cirurgiainfo:eu-repo/semantics/openAccessZoppi, RobertaDeschepper, FannySantos, Lucio LaraVideira, Paula Alexandra2024-03-14T22:04:36Zoai:revista.spcir.com:article/816Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:40.030750Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED? CANCRO COLORETAL ENTRE A APLICAÇÃO CLÍNICA E A INVESTIGAÇÃO TRANSLACIONAL – ONDE ESTAMOS E O QUE PODE SER MELHORADO? |
title |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED? |
spellingShingle |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED? Zoppi, Roberta |
title_short |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED? |
title_full |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED? |
title_fullStr |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED? |
title_full_unstemmed |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED? |
title_sort |
COLORECTAL CANCER IN-BETWEEN CLINICAL APPLICATION AND TRANSLATIONAL RESEARCH: WHERE DO WE STAND AND WHAT CAN BE IMPROVED? |
author |
Zoppi, Roberta |
author_facet |
Zoppi, Roberta Deschepper, Fanny Santos, Lucio Lara Videira, Paula Alexandra |
author_role |
author |
author2 |
Deschepper, Fanny Santos, Lucio Lara Videira, Paula Alexandra |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Zoppi, Roberta Deschepper, Fanny Santos, Lucio Lara Videira, Paula Alexandra |
description |
Colorectal cancer remains the second deadliest type of cancer with many causes resulting in a severe outcome. It is well recognized the higher level of cellular heterogeneity of colorectal cancer respect to any other type of cancer, which plays a significant role in its diagnosis, prognosis and treatment. Colorectal cancer is a curable disease when detected in early phases, up to 90% when detected in stage I, but the absence of symptoms makes the diagnosis a problematic process. Thus, the understanding of the tumour dynamics, cancer genetics and the expression of specific tumour biomarkers is crucial for the cancer early detection. Furthermore, parallel studies demonstrated the determinant role of post-translational modification in cancer formation and progression. This review aims to resume and combine all the different aspects involved in colorectal cancer malignancy, important for clinicians and researchers to understand where we currently stand, and which improvements are required. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.34635/rpc.816 https://doi.org/10.34635/rpc.816 |
url |
https://doi.org/10.34635/rpc.816 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spcir.com/index.php/spcir/article/view/816 https://revista.spcir.com/index.php/spcir/article/view/816/564 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Revista Portuguesa de Cirurgia info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Revista Portuguesa de Cirurgia |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
dc.source.none.fl_str_mv |
Revista Portuguesa de Cirurgia; No 48 (2020): Number 48 - September 2020; 65-80 Revista Portuguesa de Cirurgia; No 48 (2020): Number 48 - September 2020; 65-80 2183-1165 1646-6918 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799138181935792128 |