BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/55222 |
Resumo: | © 2020 by The American Society of Hematology |
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BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation© 2020 by The American Society of HematologyClinical disease caused by BK virus reactivation is a frequent complication of allogeneic hematopoietic cell transplantation (HCT). Because of the lack of effective antiviral agents, BK virus-specific T cells are emerging as a potential therapy for BK virus disease, but the immune response to BK virus after allogeneic HCT has not been well characterized. Our study describes reconstitution of BK virus-specific T-cell immunity in 77 adult patients after HCT. All patients had urinary symptoms, and urine was tested for BK virus replication; 33 patients were positive for BK virus (cases), and 44 were negative (controls). In BK virus cases, the median time to first positive test was 75 days (range, 2-511). BK virus cases had lower CD4 T-cell counts 3 to 9 months after transplant, but CD8 T-cell counts were similar in cases and controls. BK virus-specific T cells were identified by cytokine flow cytometry in cryopreserved samples collected prospectively. BK virus-specific CD4 T cells producing T helper 1 (Th1) cytokines recovered quickly after HCT. BK virus-specific T cells were detected more frequently in patients with BK virus reactivation at most time points, and CD4 T cells producing Th1 cytokines were more frequent than BK virus-specific cytolytic CD8 T cells. Early detection of interferon-γ+ and cytolytic BK virus-specific CD4 T cells was associated with lower rates of hematuria among cases. Overall, our study describes recovery of BK virus-specific T cells after HCT and the distinct roles for BK virus-specific T cells in the development and resolution of clinical symptoms.This work was supported by a Collaborative Research Grant from the Harvard Medical School–Portugal Program in Translational Research HMSP-ICT/0001/201, National Institutes of Health, National Cancer Institute grants CA183559, CA183560, and CA229092, and the Pasquarello Tissue Bank in Hematologic Malignancies. E.E. is a PhD candidate at Universidade de Lisboa, and this work is submitted in partial fulfillment of the requirement for a PhD and was supported by a grant for medical fellows enrolled in a PhD program (Subsídios aos Internos Doutorandos–SINTD) from Fundação para a Ciência e Tecnologia, number SFRH/SINTD/135312/2017ASH PublicationsRepositório da Universidade de LisboaRitz, JeromeMarty, Francisco M.Soiffer, Robert J.Antin, Joseph H.Koreth, JohnHo, Vincent T.Cutler, Corey S.Armand, PhilippeAlyea, Edwin P.Romee, RizwanGooptu, MahaswetaNikiforow, SarahLacerda, JoãoSoares, Maria VieiraForcade, EdouardAvigan, Jason I.Woolley, Ann E.Kim, Haesook T.Cheng, Matthew P.Espada, Eduardo2022-11-23T15:18:06Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55222engBlood Adv. 2020 May 12;4(9):1881-18932473-952910.1182/bloodadvances.20190011202473-9537info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:01Zoai:repositorio.ul.pt:10451/55222Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:52.779463Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation |
| title |
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation |
| spellingShingle |
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation Ritz, Jerome |
| title_short |
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation |
| title_full |
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation |
| title_fullStr |
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation |
| title_full_unstemmed |
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation |
| title_sort |
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation |
| author |
Ritz, Jerome |
| author_facet |
Ritz, Jerome Marty, Francisco M. Soiffer, Robert J. Antin, Joseph H. Koreth, John Ho, Vincent T. Cutler, Corey S. Armand, Philippe Alyea, Edwin P. Romee, Rizwan Gooptu, Mahasweta Nikiforow, Sarah Lacerda, João Soares, Maria Vieira Forcade, Edouard Avigan, Jason I. Woolley, Ann E. Kim, Haesook T. Cheng, Matthew P. Espada, Eduardo |
| author_role |
author |
| author2 |
Marty, Francisco M. Soiffer, Robert J. Antin, Joseph H. Koreth, John Ho, Vincent T. Cutler, Corey S. Armand, Philippe Alyea, Edwin P. Romee, Rizwan Gooptu, Mahasweta Nikiforow, Sarah Lacerda, João Soares, Maria Vieira Forcade, Edouard Avigan, Jason I. Woolley, Ann E. Kim, Haesook T. Cheng, Matthew P. Espada, Eduardo |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Ritz, Jerome Marty, Francisco M. Soiffer, Robert J. Antin, Joseph H. Koreth, John Ho, Vincent T. Cutler, Corey S. Armand, Philippe Alyea, Edwin P. Romee, Rizwan Gooptu, Mahasweta Nikiforow, Sarah Lacerda, João Soares, Maria Vieira Forcade, Edouard Avigan, Jason I. Woolley, Ann E. Kim, Haesook T. Cheng, Matthew P. Espada, Eduardo |
| description |
© 2020 by The American Society of Hematology |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2022-11-23T15:18:06Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/55222 |
| url |
http://hdl.handle.net/10451/55222 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Blood Adv. 2020 May 12;4(9):1881-1893 2473-9529 10.1182/bloodadvances.2019001120 2473-9537 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
ASH Publications |
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ASH Publications |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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