Intranasal oxytocin selectively modulates large-scale brain networks in humans

Detalhes bibliográficos
Autor(a) principal: Brodmann, Kata
Data de Publicação: 2017
Outros Autores: Gruber, Oliver, Goya-Maldonado, Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54387
Resumo: © Katja Brodmann et al. 2017; Published by Mary Ann Liebert, Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling Intranasal oxytocin selectively modulates large-scale brain networks in humansAttentionfMRIFunctional connectivityLarge-scale brain networksOxytocinSalience© Katja Brodmann et al. 2017; Published by Mary Ann Liebert, Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.A growing body of evidence indicates that the neuropeptide oxytocin (OT) alters the neural correlates of socioemotional and salience processing. Yet the effects of OT over important large-scale networks involved in these processes, such as the default mode (DM), ventral attention (VA), and cingulo-opercular (CO) networks, remain unknown. Therefore, we conducted a placebo-controlled crossover study with intranasal 24 IU OT in 38 healthy male subjects using a resting-state functional magnetic resonance imaging paradigm to investigate its impact over these three networks candidates. To understand the underlying mechanisms of the neuropeptide, we compared the intranetwork connectivity for each network candidate and also the internetwork connectivity across all networks between both treatment conditions. Based on the relevance of interindividual factors for OT effects, we correlated individual network changes with behavioral performance in a decision-making task and with impulsivity scores. Our results show that OT mainly alters connectivity in the VA, on one side reducing the coupling to regions that typically form the nodes of DM, an introspective and self-referential network, and on the other side increasing the coupling to the edges of the CO, which is involved in salience processing. The results of the internetwork analyses confirmed the specificity of the OT effects. Indeed, we observed significant correlations with the erroneous performance during decision-making but not with the obtained impulsivity scores. Overall, our data support that the modulation of functional connectivity within the VA is a basic mechanism by which OT directs attentional resources from internal to external cues, preparing the brain for context-dependent salience processing.Mary Ann LiebertRepositório da Universidade de LisboaBrodmann, KataGruber, OliverGoya-Maldonado, Roberto2022-09-08T14:39:32Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54387engBrain Connect . 2017 Sep;7(7):454-4632158-001410.1089/brain.2017.05282158-0022info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:00:16Zoai:repositorio.ul.pt:10451/54387Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:56.982291Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Intranasal oxytocin selectively modulates large-scale brain networks in humans
title Intranasal oxytocin selectively modulates large-scale brain networks in humans
spellingShingle Intranasal oxytocin selectively modulates large-scale brain networks in humans
Brodmann, Kata
Attention
fMRI
Functional connectivity
Large-scale brain networks
Oxytocin
Salience
title_short Intranasal oxytocin selectively modulates large-scale brain networks in humans
title_full Intranasal oxytocin selectively modulates large-scale brain networks in humans
title_fullStr Intranasal oxytocin selectively modulates large-scale brain networks in humans
title_full_unstemmed Intranasal oxytocin selectively modulates large-scale brain networks in humans
title_sort Intranasal oxytocin selectively modulates large-scale brain networks in humans
author Brodmann, Kata
author_facet Brodmann, Kata
Gruber, Oliver
Goya-Maldonado, Roberto
author_role author
author2 Gruber, Oliver
Goya-Maldonado, Roberto
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Brodmann, Kata
Gruber, Oliver
Goya-Maldonado, Roberto
dc.subject.por.fl_str_mv Attention
fMRI
Functional connectivity
Large-scale brain networks
Oxytocin
Salience
topic Attention
fMRI
Functional connectivity
Large-scale brain networks
Oxytocin
Salience
description © Katja Brodmann et al. 2017; Published by Mary Ann Liebert, Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2022-09-08T14:39:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54387
url http://hdl.handle.net/10451/54387
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brain Connect . 2017 Sep;7(7):454-463
2158-0014
10.1089/brain.2017.0528
2158-0022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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