Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/24093 |
Resumo: | We thank Dr. Cristina Massi Benedetti for digital art and editing |
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Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasisDectin-1Mucosal candidiasisTh1/Th17II-22genetic backgroundMucosal candidiasis, Th1/Th17, Il-22, genetic backgroundScience & TechnologyWe thank Dr. Cristina Massi Benedetti for digital art and editingRecognition of β-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses. Here, we report that the functional activity of dectin-1 in mucosal immunity to Candida albicans is influenced by the genetic background of the host. Dectin-1 was required for the proper control of gastrointestinal and vaginal candidiasis in C57BL/6 but not BALB/c mice, the latter actually showing increased resistance in the absence of dectin-1. Susceptibility of dectin-1-deficient C57BL/6 mice to infection was associated with defective IL-17A, aryl hydrocarbon receptor-dependent IL-22 production as well as adaptive Th1 responses. In contrast, resistance of dectin-1-deficient BALB/c mice was associated with increased IL-17A and IL-22 production, and the skewing towards Th1/Treg immune responses that provide immunological memory. Disparate canonical/noncanonical NF-κB signaling pathways downstream dectin-1were activated in the two different mouse strains. Thus, the net activity of dectin-1 in antifungal mucosal immunity is dependent on the host’s genetic background that affects both the innate cytokine production as well as the adaptive Th1/Th17 cell activation upon dectin-1 signaling.The studies were supported by the Specific Targeted Research Project “ALLFUN” (FP7−HEALTH−2009 contract number 260338 to LR) and the Italian Project AIDS 2010 by ISS (Istituto Superiore di Sanità - contract number 40H40 to LR) and Fondazione Cassa di Risparmio di Perugia Project n. 2011.0124.021. AC and CC were financially supported by fellowships from Fundação para a Ciência e Tecnologia, Portugal (contracts SFRH/BPD/46292/2008 and SFRH/BD/65962/2009, respectively).Nature Publishing GroupUniversidade do MinhoCarvalho, AgostinhoGiovannini, GloriaDe Luca, AntonellaD’Angelo, CarmenCasagrande, AndreaIannitti, Rossana G.Ricci, GiovanniCunha, CristinaRomani, Luigina2012-052012-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24093eng1672-768110.1038/cmi.2012.122543832http://dx.doi.org/10.1038/cmi.2012.1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:59Zoai:repositorium.sdum.uminho.pt:1822/24093Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:06:12.569394Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis |
| title |
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis |
| spellingShingle |
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis Carvalho, Agostinho Dectin-1 Mucosal candidiasis Th1/Th17 II-22 genetic background Mucosal candidiasis, Th1/Th17, Il-22, genetic background Science & Technology |
| title_short |
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis |
| title_full |
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis |
| title_fullStr |
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis |
| title_full_unstemmed |
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis |
| title_sort |
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis |
| author |
Carvalho, Agostinho |
| author_facet |
Carvalho, Agostinho Giovannini, Gloria De Luca, Antonella D’Angelo, Carmen Casagrande, Andrea Iannitti, Rossana G. Ricci, Giovanni Cunha, Cristina Romani, Luigina |
| author_role |
author |
| author2 |
Giovannini, Gloria De Luca, Antonella D’Angelo, Carmen Casagrande, Andrea Iannitti, Rossana G. Ricci, Giovanni Cunha, Cristina Romani, Luigina |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Carvalho, Agostinho Giovannini, Gloria De Luca, Antonella D’Angelo, Carmen Casagrande, Andrea Iannitti, Rossana G. Ricci, Giovanni Cunha, Cristina Romani, Luigina |
| dc.subject.por.fl_str_mv |
Dectin-1 Mucosal candidiasis Th1/Th17 II-22 genetic background Mucosal candidiasis, Th1/Th17, Il-22, genetic background Science & Technology |
| topic |
Dectin-1 Mucosal candidiasis Th1/Th17 II-22 genetic background Mucosal candidiasis, Th1/Th17, Il-22, genetic background Science & Technology |
| description |
We thank Dr. Cristina Massi Benedetti for digital art and editing |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-05 2012-05-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/24093 |
| url |
http://hdl.handle.net/1822/24093 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1672-7681 10.1038/cmi.2012.1 22543832 http://dx.doi.org/10.1038/cmi.2012.1 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Nature Publishing Group |
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Nature Publishing Group |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132476399943680 |