The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13667 |
Resumo: | Texto completo: acesso restrito. p. 607-613 |
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Ramasawmy, RajendranathMenezes, ElianeMagalhães, AndreaOliveira, JoyceCastellucci, LéaAlmeida, Roque Pacheco deRosa, Maria Elisa AlvesGuimarães, Luiz HenriqueLessa, MarcusCarvalho Filho, Edgar Marcelino deJesus, Amélia Ribeiro deRamasawmy, RajendranathMenezes, ElianeMagalhães, AndreaOliveira, JoyceCastellucci, LéaAlmeida, Roque Pacheco deRosa, Maria Elisa AlvesGuimarães, Luiz HenriqueLessa, MarcusCarvalho Filho, Edgar Marcelino deJesus, Amélia Ribeiro de2013-11-16T12:54:26Z20101567-1348http://repositorio.ufba.br/ri/handle/ri/13667v. 10, n. 5Texto completo: acesso restrito. p. 607-613Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML. Proinflammatory monocyte chemoattractant protein 1 (MCP-1; encoded by CCL2) is associated with CL. We explore its role in CL/ML through analysis of the regulatory CCL2 −2518 bp promoter polymorphism in CL/ML population samples and families from Brazil. Genotype frequencies were compared among ML/CL cases and control groups using logistic regression and the family-based association test (FBAT). MCP-1 was measured in plasma and macrophages. The GG recessive genotype at CCL2 −2518 bp was more common in patients with ML (N = 67) than in neighborhood control (NC; N = 60) subjects (OR 1.78; 95% CI 1.01–3.14; P = 0.045), than in NC combined with leishmanin skin-test positive (N = 60) controls (OR 4.40; 95% CI 1.42–13.65; P = 0.010), and than in controls combined with CL (N = 60) patients (OR 2.78; 95% CI 1.13–6.85; P = 0.045). No associations were observed for CL compared to any groups. FBAT (91 ML and 223 CL cases in families) confirmed recessive association of ML with allele G (Z = 2.679; P = 0.007). Higher levels of MCP-1 occurred in plasma (P = 0.03) and macrophages (P < 0.0001) from GG compared to AA individuals. These results suggest that high MCP-1 increases risk of ML.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-27T11:24:37Z No. of bitstreams: 1 1-s2.0-S1567134810001048-main.pdf: 190164 bytes, checksum: 653f3fd37a385fc9938a5a0dd06157ac (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-16T12:54:26Z (GMT) No. of bitstreams: 1 1-s2.0-S1567134810001048-main.pdf: 190164 bytes, checksum: 653f3fd37a385fc9938a5a0dd06157ac (MD5)Made available in DSpace on 2013-11-16T12:54:26Z (GMT). No. of bitstreams: 1 1-s2.0-S1567134810001048-main.pdf: 190164 bytes, checksum: 653f3fd37a385fc9938a5a0dd06157ac (MD5) Previous issue date: 2010http://dx.doi.org/10.1016/j.meegid.2010.04.006reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMucosal leishmaniasisGenetic associationMCP-1CCL2The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in BrazilInfection, Genetics and Evolutioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S1567134810001048-main.pdf1-s2.0-S1567134810001048-main.pdfapplication/pdf190164https://repositorio.ufba.br/bitstream/ri/13667/1/1-s2.0-S1567134810001048-main.pdf653f3fd37a385fc9938a5a0dd06157acMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13667/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S1567134810001048-main.pdf.txt1-s2.0-S1567134810001048-main.pdf.txtExtracted texttext/plain42663https://repositorio.ufba.br/bitstream/ri/13667/3/1-s2.0-S1567134810001048-main.pdf.txt8390d93cb6118e137e28808dcfb06a1fMD53ri/136672022-07-05 14:02:58.566oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:58Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil |
| dc.title.alternative.pt_BR.fl_str_mv |
Infection, Genetics and Evolution |
| title |
The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil |
| spellingShingle |
The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil Ramasawmy, Rajendranath Mucosal leishmaniasis Genetic association MCP-1 CCL2 |
| title_short |
The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil |
| title_full |
The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil |
| title_fullStr |
The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil |
| title_full_unstemmed |
The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil |
| title_sort |
The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil |
| author |
Ramasawmy, Rajendranath |
| author_facet |
Ramasawmy, Rajendranath Menezes, Eliane Magalhães, Andrea Oliveira, Joyce Castellucci, Léa Almeida, Roque Pacheco de Rosa, Maria Elisa Alves Guimarães, Luiz Henrique Lessa, Marcus Carvalho Filho, Edgar Marcelino de Jesus, Amélia Ribeiro de |
| author_role |
author |
| author2 |
Menezes, Eliane Magalhães, Andrea Oliveira, Joyce Castellucci, Léa Almeida, Roque Pacheco de Rosa, Maria Elisa Alves Guimarães, Luiz Henrique Lessa, Marcus Carvalho Filho, Edgar Marcelino de Jesus, Amélia Ribeiro de |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ramasawmy, Rajendranath Menezes, Eliane Magalhães, Andrea Oliveira, Joyce Castellucci, Léa Almeida, Roque Pacheco de Rosa, Maria Elisa Alves Guimarães, Luiz Henrique Lessa, Marcus Carvalho Filho, Edgar Marcelino de Jesus, Amélia Ribeiro de Ramasawmy, Rajendranath Menezes, Eliane Magalhães, Andrea Oliveira, Joyce Castellucci, Léa Almeida, Roque Pacheco de Rosa, Maria Elisa Alves Guimarães, Luiz Henrique Lessa, Marcus Carvalho Filho, Edgar Marcelino de Jesus, Amélia Ribeiro de |
| dc.subject.por.fl_str_mv |
Mucosal leishmaniasis Genetic association MCP-1 CCL2 |
| topic |
Mucosal leishmaniasis Genetic association MCP-1 CCL2 |
| description |
Texto completo: acesso restrito. p. 607-613 |
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2010 |
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2010 |
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2013-11-16T12:54:26Z |
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info:eu-repo/semantics/publishedVersion |
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1567-1348 |
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v. 10, n. 5 |
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1567-1348 v. 10, n. 5 |
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http://dx.doi.org/10.1016/j.meegid.2010.04.006 |
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