Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/50705 |
Resumo: | © The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease© The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for diagnosing or for following disease progression, a major limitation for the clinical practice. Posttranslational modifications (PTMs) in aSyn have been identified and implicated on its pathobiology. Since aSyn is abundant in blood erythrocytes, we aimed to evaluate whether PTMs of aSyn in the blood might hold value as a biomarker for PD. We examined 58 patients with PD and 30 healthy age-matched individuals. We found that the levels of Y125 phosphorylated, Y39 nitrated, and glycated aSyn were increased in PD, while those of SUMO were reduced. A combinatory analysis of the levels of these PTMs resulted in an increased sensitivity, with an area under curve (AUC) of 0.843 for PD versus healthy controls, and correlated with disease severity and duration. We conclude that the levels of these selected PTMs hold strong potential as biochemical markers for PD. Ultimately, our findings might facilitate the monitoring of disease progression in clinical trials, opening the possibility for developing more effective therapies against PD.This study was supported by Fundação para a Ciência e Tecnologia (FCT) EXPL/NEU-OSD/0606/2012, PTDC/NEU-OSD/5644/2014. Authors were supported by: HVM (FCT, SFRH/BPD/64702/2009, SFRH/BPD/109347/2015); MG (FCT, EXPL/NEU-OSD/0606/2012); TFO (DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain - CNMPB).Springer NatureRepositório da Universidade de LisboaVicente Miranda, HugoCassio, RafaelaCorreia Guedes, LeonorGomes, Marcos AntónioChegão, AnaMiranda, ElisaSoares, TiagoCoelho, MiguelRosa, Mário MiguelFerreira, Joaquim JOuteiro, Tiago2022-01-05T12:12:54Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50705engSci Rep. 2017 Oct 20;7(1):1371310.1038/s41598-017-14175-52045-2322info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:55:00Zoai:repositorio.ul.pt:10451/50705Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:05.977744Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease |
title |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease |
spellingShingle |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease Vicente Miranda, Hugo |
title_short |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease |
title_full |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease |
title_fullStr |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease |
title_full_unstemmed |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease |
title_sort |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease |
author |
Vicente Miranda, Hugo |
author_facet |
Vicente Miranda, Hugo Cassio, Rafaela Correia Guedes, Leonor Gomes, Marcos António Chegão, Ana Miranda, Elisa Soares, Tiago Coelho, Miguel Rosa, Mário Miguel Ferreira, Joaquim J Outeiro, Tiago |
author_role |
author |
author2 |
Cassio, Rafaela Correia Guedes, Leonor Gomes, Marcos António Chegão, Ana Miranda, Elisa Soares, Tiago Coelho, Miguel Rosa, Mário Miguel Ferreira, Joaquim J Outeiro, Tiago |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Vicente Miranda, Hugo Cassio, Rafaela Correia Guedes, Leonor Gomes, Marcos António Chegão, Ana Miranda, Elisa Soares, Tiago Coelho, Miguel Rosa, Mário Miguel Ferreira, Joaquim J Outeiro, Tiago |
description |
© The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2022-01-05T12:12:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50705 |
url |
http://hdl.handle.net/10451/50705 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sci Rep. 2017 Oct 20;7(1):13713 10.1038/s41598-017-14175-5 2045-2322 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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