Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://doi.org/10.1038/s41598-017-14175-5 |
Resumo: | We are thankful to the patients and participants for their kind participation and donation of samples. This study was supported by Fundacao para a Ciencia e Tecnologia (FCT) EXPL/NEU-OSD/0606/2012, PTDC/NEUOSD/5644/2014. Authors were supported by: HVM (FCT, SFRH/BPD/64702/2009, SFRH/BPD/109347/2015); MG (FCT, EXPL/NEU-OSD/0606/2012); TFO (DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain-CNMPB). |
| id |
RCAP_adc26529fb42203f5c4b0d6b0a33e816 |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/25050 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's diseaseGeneralWe are thankful to the patients and participants for their kind participation and donation of samples. This study was supported by Fundacao para a Ciencia e Tecnologia (FCT) EXPL/NEU-OSD/0606/2012, PTDC/NEUOSD/5644/2014. Authors were supported by: HVM (FCT, SFRH/BPD/64702/2009, SFRH/BPD/109347/2015); MG (FCT, EXPL/NEU-OSD/0606/2012); TFO (DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain-CNMPB).Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for diagnosing or for following disease progression, a major limitation for the clinical practice. Posttranslational modifications (PTMs) in aSyn have been identified and implicated on its pathobiology. Since aSyn is abundant in blood erythrocytes, we aimed to evaluate whether PTMs of aSyn in the blood might hold value as a biomarker for PD. We examined 58 patients with PD and 30 healthy age-matched individuals. We found that the levels of Y125 phosphorylated, Y39 nitrated, and glycated aSyn were increased in PD, while those of SUMO were reduced. A combinatory analysis of the levels of these PTMs resulted in an increased sensitivity, with an area under curve (AUC) of 0.843 for PD versus healthy controls, and correlated with disease severity and duration. We conclude that the levels of these selected PTMs hold strong potential as biochemical markers for PD. Ultimately, our findings might facilitate the monitoring of disease progression in clinical trials, opening the possibility for developing more effective therapies against PD.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNMiranda, Hugo VicenteCássio, RafaelaCorreia-Guedes, LeonorGomes, Marcos AntónioChegão, AnaMiranda, ElisaSoares, TiagoCoelho, MiguelRosa, Mário MiguelFerreira, Joaquim J.Outeiro, Tiago Fleming2017-11-06T23:02:43Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttps://doi.org/10.1038/s41598-017-14175-5eng2045-2322PURE: 3278147http://www.scopus.com/inward/record.url?scp=85032025050&partnerID=8YFLogxKhttps://doi.org/10.1038/s41598-017-14175-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:13:04Zoai:run.unl.pt:10362/25050Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:11.202138Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease |
| title |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease |
| spellingShingle |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease Miranda, Hugo Vicente General |
| title_short |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease |
| title_full |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease |
| title_fullStr |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease |
| title_full_unstemmed |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease |
| title_sort |
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease |
| author |
Miranda, Hugo Vicente |
| author_facet |
Miranda, Hugo Vicente Cássio, Rafaela Correia-Guedes, Leonor Gomes, Marcos António Chegão, Ana Miranda, Elisa Soares, Tiago Coelho, Miguel Rosa, Mário Miguel Ferreira, Joaquim J. Outeiro, Tiago Fleming |
| author_role |
author |
| author2 |
Cássio, Rafaela Correia-Guedes, Leonor Gomes, Marcos António Chegão, Ana Miranda, Elisa Soares, Tiago Coelho, Miguel Rosa, Mário Miguel Ferreira, Joaquim J. Outeiro, Tiago Fleming |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
Miranda, Hugo Vicente Cássio, Rafaela Correia-Guedes, Leonor Gomes, Marcos António Chegão, Ana Miranda, Elisa Soares, Tiago Coelho, Miguel Rosa, Mário Miguel Ferreira, Joaquim J. Outeiro, Tiago Fleming |
| dc.subject.por.fl_str_mv |
General |
| topic |
General |
| description |
We are thankful to the patients and participants for their kind participation and donation of samples. This study was supported by Fundacao para a Ciencia e Tecnologia (FCT) EXPL/NEU-OSD/0606/2012, PTDC/NEUOSD/5644/2014. Authors were supported by: HVM (FCT, SFRH/BPD/64702/2009, SFRH/BPD/109347/2015); MG (FCT, EXPL/NEU-OSD/0606/2012); TFO (DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain-CNMPB). |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-11-06T23:02:43Z 2017 2017-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://doi.org/10.1038/s41598-017-14175-5 |
| url |
https://doi.org/10.1038/s41598-017-14175-5 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2045-2322 PURE: 3278147 http://www.scopus.com/inward/record.url?scp=85032025050&partnerID=8YFLogxK https://doi.org/10.1038/s41598-017-14175-5 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
11 application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799137908520648704 |