In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes

Detalhes bibliográficos
Autor(a) principal: Cortes, Sofia
Data de Publicação: 2015
Outros Autores: Albuquerque, Andreia, Cabral, Lília I L, Lopes, Liliana, Campino, Lenea, Cristiano, Maria L S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1128/AAC.00298-15
Resumo: PMID: 26014947 WOS:000362952000090
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spelling In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanesPharmacologyInfectious DiseasesPharmacology (medical)SDG 3 - Good Health and Well-beingPMID: 26014947 WOS:000362952000090Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNCortes, SofiaAlbuquerque, AndreiaCabral, Lília I LLopes, LilianaCampino, LeneaCristiano, Maria L S2018-05-14T22:01:36Z2015-08-012015-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article4application/pdfhttps://doi.org/10.1128/AAC.00298-15eng0066-4804PURE: 1645540http://www.scopus.com/inward/record.url?scp=84940196134&partnerID=8YFLogxKhttps://doi.org/10.1128/AAC.00298-15info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:20:28Zoai:run.unl.pt:10362/36927Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:42.203787Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
title In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
spellingShingle In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
Cortes, Sofia
Pharmacology
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
title_short In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
title_full In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
title_fullStr In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
title_full_unstemmed In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
title_sort In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
author Cortes, Sofia
author_facet Cortes, Sofia
Albuquerque, Andreia
Cabral, Lília I L
Lopes, Liliana
Campino, Lenea
Cristiano, Maria L S
author_role author
author2 Albuquerque, Andreia
Cabral, Lília I L
Lopes, Liliana
Campino, Lenea
Cristiano, Maria L S
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
Vector borne diseases and pathogens (VBD)
RUN
dc.contributor.author.fl_str_mv Cortes, Sofia
Albuquerque, Andreia
Cabral, Lília I L
Lopes, Liliana
Campino, Lenea
Cristiano, Maria L S
dc.subject.por.fl_str_mv Pharmacology
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
topic Pharmacology
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
description PMID: 26014947 WOS:000362952000090
publishDate 2015
dc.date.none.fl_str_mv 2015-08-01
2015-08-01T00:00:00Z
2018-05-14T22:01:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1128/AAC.00298-15
url https://doi.org/10.1128/AAC.00298-15
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0066-4804
PURE: 1645540
http://www.scopus.com/inward/record.url?scp=84940196134&partnerID=8YFLogxK
https://doi.org/10.1128/AAC.00298-15
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4
application/pdf
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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