Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection

Detalhes bibliográficos
Autor(a) principal: Soares, R.
Data de Publicação: 2006
Outros Autores: Foxall, R., Albuquerque, A., Cortesão, C., Garcia, M., Victorino, R. M., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/15880
Resumo: © 2006, American Society for Microbiology. All Rights Reserved.
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spelling Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection© 2006, American Society for Microbiology. All Rights Reserved.CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.This work was supported by grants from Fundação para a Ciência e a Tecnologia (FCT) and Comissão Nacional de Luta Contra a SIDA to A.E.S. R.S., R.F., and C.C. received scholarships from FCT.American Society for MicrobiologyRepositório da Universidade de LisboaSoares, R.Foxall, R.Albuquerque, A.Cortesão, C.Garcia, M.Victorino, R. M.Sousa, A. E.2015-02-03T16:46:43Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/15880engJournal of Virology, Dec. 2006, Vol. 80, No. 24, p. 12425–124290022-538Xhttp://dx.doi.org/ 10.1128/JVI.01557-06info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:02:48Zoai:repositorio.ul.pt:10451/15880Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:10.886278Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
spellingShingle Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
Soares, R.
title_short Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title_full Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title_fullStr Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title_full_unstemmed Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title_sort Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
author Soares, R.
author_facet Soares, R.
Foxall, R.
Albuquerque, A.
Cortesão, C.
Garcia, M.
Victorino, R. M.
Sousa, A. E.
author_role author
author2 Foxall, R.
Albuquerque, A.
Cortesão, C.
Garcia, M.
Victorino, R. M.
Sousa, A. E.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Soares, R.
Foxall, R.
Albuquerque, A.
Cortesão, C.
Garcia, M.
Victorino, R. M.
Sousa, A. E.
description © 2006, American Society for Microbiology. All Rights Reserved.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
2015-02-03T16:46:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/15880
url http://hdl.handle.net/10451/15880
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Virology, Dec. 2006, Vol. 80, No. 24, p. 12425–12429
0022-538X
http://dx.doi.org/ 10.1128/JVI.01557-06
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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