PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review

Detalhes bibliográficos
Autor(a) principal: Lopes, Susana Isabel
Data de Publicação: 2021
Outros Autores: Ferreira, Sara, Caetano, Marco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/13161
Resumo: Introduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival.
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spelling PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature reviewMolecular imagingOncology, Head and neckPET/CTRadiopharmaceuticalsHead and neck tumoursHypoxic cellsRadiotherapyTreatment planningIntroduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival.SNMMIRCIPLLopes, Susana IsabelFerreira, SaraCaetano, Marco2021-03-27T18:15:33Z2021-062021-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13161engLopes SI, Ferreira S, Caetano M. PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review. J Nucl Med Technol. 2021;49(2):107-13.10.2967/jnmt.120.249540info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:07:24Zoai:repositorio.ipl.pt:10400.21/13161Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:09.614803Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
title PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
spellingShingle PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
Lopes, Susana Isabel
Molecular imaging
Oncology, Head and neck
PET/CT
Radiopharmaceuticals
Head and neck tumours
Hypoxic cells
Radiotherapy
Treatment planning
title_short PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
title_full PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
title_fullStr PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
title_full_unstemmed PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
title_sort PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
author Lopes, Susana Isabel
author_facet Lopes, Susana Isabel
Ferreira, Sara
Caetano, Marco
author_role author
author2 Ferreira, Sara
Caetano, Marco
author2_role author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Lopes, Susana Isabel
Ferreira, Sara
Caetano, Marco
dc.subject.por.fl_str_mv Molecular imaging
Oncology, Head and neck
PET/CT
Radiopharmaceuticals
Head and neck tumours
Hypoxic cells
Radiotherapy
Treatment planning
topic Molecular imaging
Oncology, Head and neck
PET/CT
Radiopharmaceuticals
Head and neck tumours
Hypoxic cells
Radiotherapy
Treatment planning
description Introduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-27T18:15:33Z
2021-06
2021-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/13161
url http://hdl.handle.net/10400.21/13161
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lopes SI, Ferreira S, Caetano M. PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review. J Nucl Med Technol. 2021;49(2):107-13.
10.2967/jnmt.120.249540
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SNMMI
publisher.none.fl_str_mv SNMMI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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