PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/13161 |
Resumo: | Introduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival. |
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PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature reviewMolecular imagingOncology, Head and neckPET/CTRadiopharmaceuticalsHead and neck tumoursHypoxic cellsRadiotherapyTreatment planningIntroduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival.SNMMIRCIPLLopes, Susana IsabelFerreira, SaraCaetano, Marco2021-03-27T18:15:33Z2021-062021-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13161engLopes SI, Ferreira S, Caetano M. PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review. J Nucl Med Technol. 2021;49(2):107-13.10.2967/jnmt.120.249540info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:07:24Zoai:repositorio.ipl.pt:10400.21/13161Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:09.614803Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review |
title |
PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review |
spellingShingle |
PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review Lopes, Susana Isabel Molecular imaging Oncology, Head and neck PET/CT Radiopharmaceuticals Head and neck tumours Hypoxic cells Radiotherapy Treatment planning |
title_short |
PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review |
title_full |
PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review |
title_fullStr |
PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review |
title_full_unstemmed |
PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review |
title_sort |
PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review |
author |
Lopes, Susana Isabel |
author_facet |
Lopes, Susana Isabel Ferreira, Sara Caetano, Marco |
author_role |
author |
author2 |
Ferreira, Sara Caetano, Marco |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Lopes, Susana Isabel Ferreira, Sara Caetano, Marco |
dc.subject.por.fl_str_mv |
Molecular imaging Oncology, Head and neck PET/CT Radiopharmaceuticals Head and neck tumours Hypoxic cells Radiotherapy Treatment planning |
topic |
Molecular imaging Oncology, Head and neck PET/CT Radiopharmaceuticals Head and neck tumours Hypoxic cells Radiotherapy Treatment planning |
description |
Introduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-27T18:15:33Z 2021-06 2021-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/13161 |
url |
http://hdl.handle.net/10400.21/13161 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lopes SI, Ferreira S, Caetano M. PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review. J Nucl Med Technol. 2021;49(2):107-13. 10.2967/jnmt.120.249540 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SNMMI |
publisher.none.fl_str_mv |
SNMMI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133482271637504 |