Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8668 |
Resumo: | Review |
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Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledgeEnvironmental GenotoxicityEffect BiomarkersHuman BiomonitoringGenotoxicidade AmbientalReviewHuman biomonitoring (HBM) studies have highlighted widespread daily exposure to environmental chemicals. Some of these are suspected to contribute to adverse health outcomes such as reproductive, neurological, and metabolic disorders, among other developmental and chronic impairments. One of the objectives of the H2020 European Human Biomonitoring Initiative (HBM4EU) was the development of informative effect biomarkers for application in a more systematic and harmonized way in large-scale European HBM studies. The inclusion of effect biomarkers would complement exposure data with mechanistically-based information on early and late adverse effects. For this purpose, a stepwise strategy was developed to identify and implement a panel of validated effect biomarkers in European HBM studies. This work offers an overview of the complete procedure followed, from comprehensive literature search strategies, selection of criteria for effect biomarkers and their classification and prioritization, based on toxicological data and adverse outcomes, to pilot studies for their analytical, physiological, and epidemiological validation. We present the example of one study that demonstrated the mediating role of the effect biomarker status of brain-derived neurotrophic factor BDNF in the longitudinal association between infant bisphenol A (BPA) exposure and behavioral function in adolescence. A panel of effect biomarkers has been implemented in the HBM4EU Aligned Studies as main outcomes, including traditional oxidative stress, reproductive, and thyroid hormone biomarkers. Novel biomarkers of effect, such as DNA methylation status of BDNF and kisspeptin (KISS) genes were also evaluated as molecular markers of neurological and reproductive health, respectively. A panel of effect biomarkers has also been applied in HBM4EU occupational studies, such as micronucleus analysis in lymphocytes and reticulocytes, whole blood comet assay, and malondialdehyde, 8-oxo-2′-deoxyguanosine and untargeted metabolomic profile in urine, to investigate, for example, biological changes in response to hexavalent chromium Cr(VI) exposure. The use of effect biomarkers in HBM4EU has demonstrated their ability to detect early biological effects of chemical exposure and to identify subgroups that are at higher risk. The roadmap developed in HBM4EU confirms the utility of effect biomarkers, and support one of the main objectives of HBM research, which is to link exposure biomarkers to mechanistically validated effect and susceptibility biomarkers in order to better understand the public health implications of human exposure to environmental chemicals.Supported by the European Union's Horizon 2020 research and innovation program projects HBM4EU [grant number 733032]ElsevierRepositório Científico do Instituto Nacional de SaúdeRodríguez-Carrillo, AndreaMustieles, VicenteSalamanca-Fernández, ElenaOlivas-Martínez, AliciaSuárez, BeatrizBajard, LolaBaken, KirstenBlaha, LudekBonefeld-Jørgensen, Eva CecilieCouderq, StephanD'Cruz, Shereen CynthiaFini, Jean-BaptisteGovarts, EvaGundacker, ClaudiaHernández, Antonio F.Lacasaña, MarinaLaguzzi, FedericaLinderman, BirgitteLong, ManhaiLouro, HenriquetaNeophytou, ChristianaOberemn, AxelRemy, SylvieRosenmai, Anna KjerstineSaber, Anne ThoustrupSchoeters, GreetSilva, Maria JoãoSmagulova, FatimaUhl, MariaVinggaard, Anne MarieVogel, UllaWielsøe, MariaOlea, NicolásFernández, Mariana F.2023-10-06T13:24:59Z2023-02-242023-02-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8668engInt J Hyg Environ Health. 2023 Apr:249:114140. doi: 10.1016/j.ijheh.2023.114140. Epub 2023 Feb 24. Review1438-4639/10.1016/j.ijheh.2023.114140info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-14T01:31:33Zoai:repositorio.insa.pt:10400.18/8668Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:33:34.250865Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge |
| title |
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge |
| spellingShingle |
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge Rodríguez-Carrillo, Andrea Environmental Genotoxicity Effect Biomarkers Human Biomonitoring Genotoxicidade Ambiental |
| title_short |
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge |
| title_full |
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge |
| title_fullStr |
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge |
| title_full_unstemmed |
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge |
| title_sort |
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge |
| author |
Rodríguez-Carrillo, Andrea |
| author_facet |
Rodríguez-Carrillo, Andrea Mustieles, Vicente Salamanca-Fernández, Elena Olivas-Martínez, Alicia Suárez, Beatriz Bajard, Lola Baken, Kirsten Blaha, Ludek Bonefeld-Jørgensen, Eva Cecilie Couderq, Stephan D'Cruz, Shereen Cynthia Fini, Jean-Baptiste Govarts, Eva Gundacker, Claudia Hernández, Antonio F. Lacasaña, Marina Laguzzi, Federica Linderman, Birgitte Long, Manhai Louro, Henriqueta Neophytou, Christiana Oberemn, Axel Remy, Sylvie Rosenmai, Anna Kjerstine Saber, Anne Thoustrup Schoeters, Greet Silva, Maria João Smagulova, Fatima Uhl, Maria Vinggaard, Anne Marie Vogel, Ulla Wielsøe, Maria Olea, Nicolás Fernández, Mariana F. |
| author_role |
author |
| author2 |
Mustieles, Vicente Salamanca-Fernández, Elena Olivas-Martínez, Alicia Suárez, Beatriz Bajard, Lola Baken, Kirsten Blaha, Ludek Bonefeld-Jørgensen, Eva Cecilie Couderq, Stephan D'Cruz, Shereen Cynthia Fini, Jean-Baptiste Govarts, Eva Gundacker, Claudia Hernández, Antonio F. Lacasaña, Marina Laguzzi, Federica Linderman, Birgitte Long, Manhai Louro, Henriqueta Neophytou, Christiana Oberemn, Axel Remy, Sylvie Rosenmai, Anna Kjerstine Saber, Anne Thoustrup Schoeters, Greet Silva, Maria João Smagulova, Fatima Uhl, Maria Vinggaard, Anne Marie Vogel, Ulla Wielsøe, Maria Olea, Nicolás Fernández, Mariana F. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Rodríguez-Carrillo, Andrea Mustieles, Vicente Salamanca-Fernández, Elena Olivas-Martínez, Alicia Suárez, Beatriz Bajard, Lola Baken, Kirsten Blaha, Ludek Bonefeld-Jørgensen, Eva Cecilie Couderq, Stephan D'Cruz, Shereen Cynthia Fini, Jean-Baptiste Govarts, Eva Gundacker, Claudia Hernández, Antonio F. Lacasaña, Marina Laguzzi, Federica Linderman, Birgitte Long, Manhai Louro, Henriqueta Neophytou, Christiana Oberemn, Axel Remy, Sylvie Rosenmai, Anna Kjerstine Saber, Anne Thoustrup Schoeters, Greet Silva, Maria João Smagulova, Fatima Uhl, Maria Vinggaard, Anne Marie Vogel, Ulla Wielsøe, Maria Olea, Nicolás Fernández, Mariana F. |
| dc.subject.por.fl_str_mv |
Environmental Genotoxicity Effect Biomarkers Human Biomonitoring Genotoxicidade Ambiental |
| topic |
Environmental Genotoxicity Effect Biomarkers Human Biomonitoring Genotoxicidade Ambiental |
| description |
Review |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-10-06T13:24:59Z 2023-02-24 2023-02-24T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8668 |
| url |
http://hdl.handle.net/10400.18/8668 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Int J Hyg Environ Health. 2023 Apr:249:114140. doi: 10.1016/j.ijheh.2023.114140. Epub 2023 Feb 24. Review 1438-4639/ 10.1016/j.ijheh.2023.114140 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817553329317740544 |