Metal-Organic Frameworks as Sensors for Human Amyloid Diseases
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/40426 |
Resumo: | Metal-organic frameworks (MOFs) are versatile compounds with emergent applications in the fabrication of biosensors for amyloid diseases. They hold great potential in biospecimen protection and unprecedented probing capabilities for optical and redox receptors. In this Review, we summarize the main methodologies employed in the fabrication of MOF-based sensors for amyloid diseases and collect all available data in the literature related to their performance (detection range, limit of detection, recovery, time of analysis, among other parameters). Nowadays, MOF sensors have evolved to a point where they can, in some cases, outperform technologies employed in the detection of several amyloid biomarkers (amyloid β peptide, α-synuclein, insulin, procalcitonin, and prolactin) present in biological fluids, such as cerebrospinal fluid and blood. A special emphasis has been given by researchers on Alzheimer's disease monitoring to the detriment of other amyloidosis that are underexploited despite their societal relevance (e.g., Parkinson's disease). There are still important obstacles to overcome in order to selectively detect the various peptide isoforms and soluble amyloid species associated with Alzheimer's disease. Furthermore, MOF contrast agents for imaging peptide soluble oligomers in living humans are also scarce (if not nonexistent), and action in this direction is unquestionably required to clarify the contentious link between the amyloidogenic species and the disease, guiding research toward the most promising therapeutic strategies. |
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Metal-Organic Frameworks as Sensors for Human Amyloid DiseasesAlzheimer’s diseaseAmyloid biomarkeDiagnosticImmunosensorMetal−organic frameworksAmyloid diseasesBiosensorsAmyloid inhibitionMetal-organic frameworks (MOFs) are versatile compounds with emergent applications in the fabrication of biosensors for amyloid diseases. They hold great potential in biospecimen protection and unprecedented probing capabilities for optical and redox receptors. In this Review, we summarize the main methodologies employed in the fabrication of MOF-based sensors for amyloid diseases and collect all available data in the literature related to their performance (detection range, limit of detection, recovery, time of analysis, among other parameters). Nowadays, MOF sensors have evolved to a point where they can, in some cases, outperform technologies employed in the detection of several amyloid biomarkers (amyloid β peptide, α-synuclein, insulin, procalcitonin, and prolactin) present in biological fluids, such as cerebrospinal fluid and blood. A special emphasis has been given by researchers on Alzheimer's disease monitoring to the detriment of other amyloidosis that are underexploited despite their societal relevance (e.g., Parkinson's disease). There are still important obstacles to overcome in order to selectively detect the various peptide isoforms and soluble amyloid species associated with Alzheimer's disease. Furthermore, MOF contrast agents for imaging peptide soluble oligomers in living humans are also scarce (if not nonexistent), and action in this direction is unquestionably required to clarify the contentious link between the amyloidogenic species and the disease, guiding research toward the most promising therapeutic strategies.American Chemical Society2024-01-31T12:36:33Z2023-03-24T00:00:00Z2023-03-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/40426eng2379-369410.1021/acssensors.2c02741Leite, José P.Figueira, FlávioMendes, Ricardo F.Almeida Paz, Filipe A.Gales, Luísinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:19:24Zoai:ria.ua.pt:10773/40426Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:10:30.657646Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases |
title |
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases |
spellingShingle |
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases Leite, José P. Alzheimer’s disease Amyloid biomarke Diagnostic Immunosensor Metal−organic frameworks Amyloid diseases Biosensors Amyloid inhibition |
title_short |
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases |
title_full |
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases |
title_fullStr |
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases |
title_full_unstemmed |
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases |
title_sort |
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases |
author |
Leite, José P. |
author_facet |
Leite, José P. Figueira, Flávio Mendes, Ricardo F. Almeida Paz, Filipe A. Gales, Luís |
author_role |
author |
author2 |
Figueira, Flávio Mendes, Ricardo F. Almeida Paz, Filipe A. Gales, Luís |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Leite, José P. Figueira, Flávio Mendes, Ricardo F. Almeida Paz, Filipe A. Gales, Luís |
dc.subject.por.fl_str_mv |
Alzheimer’s disease Amyloid biomarke Diagnostic Immunosensor Metal−organic frameworks Amyloid diseases Biosensors Amyloid inhibition |
topic |
Alzheimer’s disease Amyloid biomarke Diagnostic Immunosensor Metal−organic frameworks Amyloid diseases Biosensors Amyloid inhibition |
description |
Metal-organic frameworks (MOFs) are versatile compounds with emergent applications in the fabrication of biosensors for amyloid diseases. They hold great potential in biospecimen protection and unprecedented probing capabilities for optical and redox receptors. In this Review, we summarize the main methodologies employed in the fabrication of MOF-based sensors for amyloid diseases and collect all available data in the literature related to their performance (detection range, limit of detection, recovery, time of analysis, among other parameters). Nowadays, MOF sensors have evolved to a point where they can, in some cases, outperform technologies employed in the detection of several amyloid biomarkers (amyloid β peptide, α-synuclein, insulin, procalcitonin, and prolactin) present in biological fluids, such as cerebrospinal fluid and blood. A special emphasis has been given by researchers on Alzheimer's disease monitoring to the detriment of other amyloidosis that are underexploited despite their societal relevance (e.g., Parkinson's disease). There are still important obstacles to overcome in order to selectively detect the various peptide isoforms and soluble amyloid species associated with Alzheimer's disease. Furthermore, MOF contrast agents for imaging peptide soluble oligomers in living humans are also scarce (if not nonexistent), and action in this direction is unquestionably required to clarify the contentious link between the amyloidogenic species and the disease, guiding research toward the most promising therapeutic strategies. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-24T00:00:00Z 2023-03-24 2024-01-31T12:36:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/40426 |
url |
http://hdl.handle.net/10773/40426 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2379-3694 10.1021/acssensors.2c02741 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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