ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/18783 |
Resumo: | Competing endogenous RNAs (ceRNAs) are vital regulators of gene networks in mammals. The involvement of noncoding RNAs (ncRNAs) as ceRNA in genotypic sex determination (GSD) and environmental sex determination (ESD) in fish is unknown. The Chinese tongue sole, which has both GSD and ESD mechanisms, was used to map the dynamic expression pattern of ncRNAs and mRNA in gonads during sex determination and differentiation. Transcript expression patterns shift during the sex differentiation phase, and ceRNA modulation occurs through crosstalk of differentially expressed long ncRNAs (lncRNAs), circular RNAs (circRNAs), microRNAs (miRNAs), and sex-related genes in fish. Of note was the significant up-regulation of a circRNA from the sex-determining gene dmrt1 (circular RNA dmrt1) and a lncRNA, called AMSDT (which stands for associated with male sex differentiation of tongue sole) in Chinese tongue sole testis. These two ncRNAs both share the same miRNA response elements with gsdf, which has an up-regulated expression when they bind to miRNA cse-miR-196 and concurrent down-regulated female sex-related genes to facilitate testis differentiation. This is the first demonstration in fish that ceRNA crosstalk mediated by ncRNAs modulates sexual development and unveils a novel regulatory mechanism for sex determination and differentiation. |
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ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiationDetermining genePRP8 proteinDMRT1MedakaChromosomePlasticityDiversityEvolutionInsightsRolesCompeting endogenous RNAs (ceRNAs) are vital regulators of gene networks in mammals. The involvement of noncoding RNAs (ncRNAs) as ceRNA in genotypic sex determination (GSD) and environmental sex determination (ESD) in fish is unknown. The Chinese tongue sole, which has both GSD and ESD mechanisms, was used to map the dynamic expression pattern of ncRNAs and mRNA in gonads during sex determination and differentiation. Transcript expression patterns shift during the sex differentiation phase, and ceRNA modulation occurs through crosstalk of differentially expressed long ncRNAs (lncRNAs), circular RNAs (circRNAs), microRNAs (miRNAs), and sex-related genes in fish. Of note was the significant up-regulation of a circRNA from the sex-determining gene dmrt1 (circular RNA dmrt1) and a lncRNA, called AMSDT (which stands for associated with male sex differentiation of tongue sole) in Chinese tongue sole testis. These two ncRNAs both share the same miRNA response elements with gsdf, which has an up-regulated expression when they bind to miRNA cse-miR-196 and concurrent down-regulated female sex-related genes to facilitate testis differentiation. This is the first demonstration in fish that ceRNA crosstalk mediated by ncRNAs modulates sexual development and unveils a novel regulatory mechanism for sex determination and differentiation.3172205831802275314722692017ASTCPES062020TD19CARS-47-G03Cold Spring Harbor Laboratory PressSapientiaTang, LiliHuang, FeiYou, WuxinPoetsch, AnsgarNóbrega, Rafael HenriquePower, DeborahZhu, TengfeiLiu, KaiqiangWang, Hong-YanWang, QianXu, XiwenFeng, BoSchartl, ManfredShao, Changwei2023-01-10T14:09:18Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/18783eng10.1101/gr.275962.1211549-5469info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:31:07Zoai:sapientia.ualg.pt:10400.1/18783Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:08:30.422945Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation |
title |
ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation |
spellingShingle |
ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation Tang, Lili Determining gene PRP8 protein DMRT1 Medaka Chromosome Plasticity Diversity Evolution Insights Roles |
title_short |
ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation |
title_full |
ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation |
title_fullStr |
ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation |
title_full_unstemmed |
ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation |
title_sort |
ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation |
author |
Tang, Lili |
author_facet |
Tang, Lili Huang, Fei You, Wuxin Poetsch, Ansgar Nóbrega, Rafael Henrique Power, Deborah Zhu, Tengfei Liu, Kaiqiang Wang, Hong-Yan Wang, Qian Xu, Xiwen Feng, Bo Schartl, Manfred Shao, Changwei |
author_role |
author |
author2 |
Huang, Fei You, Wuxin Poetsch, Ansgar Nóbrega, Rafael Henrique Power, Deborah Zhu, Tengfei Liu, Kaiqiang Wang, Hong-Yan Wang, Qian Xu, Xiwen Feng, Bo Schartl, Manfred Shao, Changwei |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Tang, Lili Huang, Fei You, Wuxin Poetsch, Ansgar Nóbrega, Rafael Henrique Power, Deborah Zhu, Tengfei Liu, Kaiqiang Wang, Hong-Yan Wang, Qian Xu, Xiwen Feng, Bo Schartl, Manfred Shao, Changwei |
dc.subject.por.fl_str_mv |
Determining gene PRP8 protein DMRT1 Medaka Chromosome Plasticity Diversity Evolution Insights Roles |
topic |
Determining gene PRP8 protein DMRT1 Medaka Chromosome Plasticity Diversity Evolution Insights Roles |
description |
Competing endogenous RNAs (ceRNAs) are vital regulators of gene networks in mammals. The involvement of noncoding RNAs (ncRNAs) as ceRNA in genotypic sex determination (GSD) and environmental sex determination (ESD) in fish is unknown. The Chinese tongue sole, which has both GSD and ESD mechanisms, was used to map the dynamic expression pattern of ncRNAs and mRNA in gonads during sex determination and differentiation. Transcript expression patterns shift during the sex differentiation phase, and ceRNA modulation occurs through crosstalk of differentially expressed long ncRNAs (lncRNAs), circular RNAs (circRNAs), microRNAs (miRNAs), and sex-related genes in fish. Of note was the significant up-regulation of a circRNA from the sex-determining gene dmrt1 (circular RNA dmrt1) and a lncRNA, called AMSDT (which stands for associated with male sex differentiation of tongue sole) in Chinese tongue sole testis. These two ncRNAs both share the same miRNA response elements with gsdf, which has an up-regulated expression when they bind to miRNA cse-miR-196 and concurrent down-regulated female sex-related genes to facilitate testis differentiation. This is the first demonstration in fish that ceRNA crosstalk mediated by ncRNAs modulates sexual development and unveils a novel regulatory mechanism for sex determination and differentiation. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2023-01-10T14:09:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/18783 |
url |
http://hdl.handle.net/10400.1/18783 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1101/gr.275962.121 1549-5469 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Cold Spring Harbor Laboratory Press |
publisher.none.fl_str_mv |
Cold Spring Harbor Laboratory Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133331410911232 |