Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems

Detalhes bibliográficos
Autor(a) principal: Baldim, Iara
Data de Publicação: 2020
Outros Autores: Oliveira, Wanderley P., Kadian, Varsha, Rao, Rekha, Yadav, Nitesh, Mahant, Sheefali, Lucarini, Massimo, Durazzo, Alessandra, Da Ana, Raquel, Capasso, Raffaele, Souto, Selma B., Santini, Antonello, Souto, Eliana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/65855
Resumo: Several pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between lysergic acid-derived compounds and noradrenalin, dopamine, and serotonin neurotransmitters. To reduce their toxicological risk, while increasing their bioavailability, improved delivery systems were proposed. This review discusses the safety aspects of using ergot alkaloids in ocular pharmacology and proposes the development of lipid and polymeric nanoparticles for the topical administration of these drugs to enhance their therapeutic efficacy for the treatment of glaucoma.
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spelling Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systemsergot alkaloidsocular pharmacologyglaucomalipid nanoparticlespolymeric nanoparticlesScience & TechnologySeveral pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between lysergic acid-derived compounds and noradrenalin, dopamine, and serotonin neurotransmitters. To reduce their toxicological risk, while increasing their bioavailability, improved delivery systems were proposed. This review discusses the safety aspects of using ergot alkaloids in ocular pharmacology and proposes the development of lipid and polymeric nanoparticles for the topical administration of these drugs to enhance their therapeutic efficacy for the treatment of glaucoma.This work was supported by CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) granted to I.B. (88887.368385/2019-00), by the Portuguese Science and Technology Foundation (FCT) and co-financed by FEDER, under the Partnership Agreement PT2020, granted to E.B.S. (UIDB/04469/2020 strategic fund), by the Nutraceutica come supporto nutrizionale nel paziente oncologico, project granted to A.S. (CUP: B83D18000140007), and by Foundation of Research Support of the São Paulo State (FAPESP) for the funded projects 2011/10333-1, 2012/03427-2, and 2018/26069-0 and for the National Council for Scientific and Technological Development (CNPq) granted to W.P.O.info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoBaldim, IaraOliveira, Wanderley P.Kadian, VarshaRao, RekhaYadav, NiteshMahant, SheefaliLucarini, MassimoDurazzo, AlessandraDa Ana, RaquelCapasso, RaffaeleSouto, Selma B.Santini, AntonelloSouto, Eliana B.2020-06-302020-06-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/65855engBaldim, Iara; Oliveira, Wanderley P.; Kadian, Varsha; Rao, Rekha; Yadav, Nitesh; Mahant, Sheefali; Lucarini, Massimo; Durazzo, Alessandra; Da Ana, Raquel; Capasso, Raffaele; Souto, Selma B.; Santini, Antonello; Souto, Eliana, Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems. Biomolecules, 10(7), 980, 20202218-273X2218-273X10.3390/biom1007098032630018https://www.mdpi.com/journal/biomoleculesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:19:40Zoai:repositorium.sdum.uminho.pt:1822/65855Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:12:38.680697Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
title Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
spellingShingle Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
Baldim, Iara
ergot alkaloids
ocular pharmacology
glaucoma
lipid nanoparticles
polymeric nanoparticles
Science & Technology
title_short Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
title_full Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
title_fullStr Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
title_full_unstemmed Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
title_sort Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
author Baldim, Iara
author_facet Baldim, Iara
Oliveira, Wanderley P.
Kadian, Varsha
Rao, Rekha
Yadav, Nitesh
Mahant, Sheefali
Lucarini, Massimo
Durazzo, Alessandra
Da Ana, Raquel
Capasso, Raffaele
Souto, Selma B.
Santini, Antonello
Souto, Eliana B.
author_role author
author2 Oliveira, Wanderley P.
Kadian, Varsha
Rao, Rekha
Yadav, Nitesh
Mahant, Sheefali
Lucarini, Massimo
Durazzo, Alessandra
Da Ana, Raquel
Capasso, Raffaele
Souto, Selma B.
Santini, Antonello
Souto, Eliana B.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Baldim, Iara
Oliveira, Wanderley P.
Kadian, Varsha
Rao, Rekha
Yadav, Nitesh
Mahant, Sheefali
Lucarini, Massimo
Durazzo, Alessandra
Da Ana, Raquel
Capasso, Raffaele
Souto, Selma B.
Santini, Antonello
Souto, Eliana B.
dc.subject.por.fl_str_mv ergot alkaloids
ocular pharmacology
glaucoma
lipid nanoparticles
polymeric nanoparticles
Science & Technology
topic ergot alkaloids
ocular pharmacology
glaucoma
lipid nanoparticles
polymeric nanoparticles
Science & Technology
description Several pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between lysergic acid-derived compounds and noradrenalin, dopamine, and serotonin neurotransmitters. To reduce their toxicological risk, while increasing their bioavailability, improved delivery systems were proposed. This review discusses the safety aspects of using ergot alkaloids in ocular pharmacology and proposes the development of lipid and polymeric nanoparticles for the topical administration of these drugs to enhance their therapeutic efficacy for the treatment of glaucoma.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-30
2020-06-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/65855
url http://hdl.handle.net/1822/65855
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Baldim, Iara; Oliveira, Wanderley P.; Kadian, Varsha; Rao, Rekha; Yadav, Nitesh; Mahant, Sheefali; Lucarini, Massimo; Durazzo, Alessandra; Da Ana, Raquel; Capasso, Raffaele; Souto, Selma B.; Santini, Antonello; Souto, Eliana, Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems. Biomolecules, 10(7), 980, 2020
2218-273X
2218-273X
10.3390/biom10070980
32630018
https://www.mdpi.com/journal/biomolecules
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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