Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients

Detalhes bibliográficos
Autor(a) principal: Costa, Elísio
Data de Publicação: 2008
Outros Autores: Rocha, Susana, Rocha-Pereira, Petronila, Nascimento, Henrique, Castro, Elisabeth, Miranda, Vasco, Faria, Maria do Sameiro, Loureiro, Alfredo, Belo, Luís, Santos-Silva, Alice
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/4376
Resumo: The aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance to recombinant human erythropoietin (rhEPO) therapy. Methods: We studied 63 CKD patients under hemodialysis and rhEPO treatment (32 responders and 31 non-responders to rhEPO therapy). In 20 of the CKD patients (10 responders and 10 non-responders to rhEPO therapy), blood samples were also collected immediately after dialysis. Twenty-six healthy volunteers were included in a control group. Hemoglobin levels, total and differential leukocyte counts, and circulating levels of C-reactive protein (CRP), elastase and lactoferrin were measured in all patients and controls. Results: Compared with controls, CKD patients presented with significantly higher CRP, neutrophil and elastase levels. When we compared the 2 groups of patients, we found that non-responders presented statistically significantly higher elastase plasma levels. A positive significant correlation was found between elastase levels and weekly rhEPO dose and CRP serum levels. After the hemodialysis procedure, a statistically significant rise in elastase, lactoferrin and, elastase/neutrophil and lactoferrin/neutrophil ratios were found. Conclusions: Our data show that CKD patients under hemodialysis present higher elastase levels (particularly in non-responding patients), which could be related to the rise in neutrophils, and to be part of the enhanced inflammatory process found in these patients
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spelling Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis PatientsrhEPO therapy, resistanceNeutrophil activationElastaseLactoferrinThe aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance to recombinant human erythropoietin (rhEPO) therapy. Methods: We studied 63 CKD patients under hemodialysis and rhEPO treatment (32 responders and 31 non-responders to rhEPO therapy). In 20 of the CKD patients (10 responders and 10 non-responders to rhEPO therapy), blood samples were also collected immediately after dialysis. Twenty-six healthy volunteers were included in a control group. Hemoglobin levels, total and differential leukocyte counts, and circulating levels of C-reactive protein (CRP), elastase and lactoferrin were measured in all patients and controls. Results: Compared with controls, CKD patients presented with significantly higher CRP, neutrophil and elastase levels. When we compared the 2 groups of patients, we found that non-responders presented statistically significantly higher elastase plasma levels. A positive significant correlation was found between elastase levels and weekly rhEPO dose and CRP serum levels. After the hemodialysis procedure, a statistically significant rise in elastase, lactoferrin and, elastase/neutrophil and lactoferrin/neutrophil ratios were found. Conclusions: Our data show that CKD patients under hemodialysis present higher elastase levels (particularly in non-responding patients), which could be related to the rise in neutrophils, and to be part of the enhanced inflammatory process found in these patientsBakris G. (Chicago, Ill.)Veritati - Repositório Institucional da Universidade Católica PortuguesaCosta, ElísioRocha, SusanaRocha-Pereira, PetronilaNascimento, HenriqueCastro, ElisabethMiranda, VascoFaria, Maria do SameiroLoureiro, AlfredoBelo, LuísSantos-Silva, Alice2011-06-03T14:32:13Z20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/4376engCOSTA, Elísio - Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients.American Journal of Nephrology. ISSN 0250-8095. Vol.28 (2008) p. 935-94010.1159/000142147info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-26T01:40:10Zoai:repositorio.ucp.pt:10400.14/4376Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:05:45.906265Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
title Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
spellingShingle Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
Costa, Elísio
rhEPO therapy, resistance
Neutrophil activation
Elastase
Lactoferrin
title_short Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
title_full Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
title_fullStr Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
title_full_unstemmed Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
title_sort Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
author Costa, Elísio
author_facet Costa, Elísio
Rocha, Susana
Rocha-Pereira, Petronila
Nascimento, Henrique
Castro, Elisabeth
Miranda, Vasco
Faria, Maria do Sameiro
Loureiro, Alfredo
Belo, Luís
Santos-Silva, Alice
author_role author
author2 Rocha, Susana
Rocha-Pereira, Petronila
Nascimento, Henrique
Castro, Elisabeth
Miranda, Vasco
Faria, Maria do Sameiro
Loureiro, Alfredo
Belo, Luís
Santos-Silva, Alice
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Costa, Elísio
Rocha, Susana
Rocha-Pereira, Petronila
Nascimento, Henrique
Castro, Elisabeth
Miranda, Vasco
Faria, Maria do Sameiro
Loureiro, Alfredo
Belo, Luís
Santos-Silva, Alice
dc.subject.por.fl_str_mv rhEPO therapy, resistance
Neutrophil activation
Elastase
Lactoferrin
topic rhEPO therapy, resistance
Neutrophil activation
Elastase
Lactoferrin
description The aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance to recombinant human erythropoietin (rhEPO) therapy. Methods: We studied 63 CKD patients under hemodialysis and rhEPO treatment (32 responders and 31 non-responders to rhEPO therapy). In 20 of the CKD patients (10 responders and 10 non-responders to rhEPO therapy), blood samples were also collected immediately after dialysis. Twenty-six healthy volunteers were included in a control group. Hemoglobin levels, total and differential leukocyte counts, and circulating levels of C-reactive protein (CRP), elastase and lactoferrin were measured in all patients and controls. Results: Compared with controls, CKD patients presented with significantly higher CRP, neutrophil and elastase levels. When we compared the 2 groups of patients, we found that non-responders presented statistically significantly higher elastase plasma levels. A positive significant correlation was found between elastase levels and weekly rhEPO dose and CRP serum levels. After the hemodialysis procedure, a statistically significant rise in elastase, lactoferrin and, elastase/neutrophil and lactoferrin/neutrophil ratios were found. Conclusions: Our data show that CKD patients under hemodialysis present higher elastase levels (particularly in non-responding patients), which could be related to the rise in neutrophils, and to be part of the enhanced inflammatory process found in these patients
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
2011-06-03T14:32:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/4376
url http://hdl.handle.net/10400.14/4376
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv COSTA, Elísio - Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients.American Journal of Nephrology. ISSN 0250-8095. Vol.28 (2008) p. 935-940
10.1159/000142147
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bakris G. (Chicago, Ill.)
publisher.none.fl_str_mv Bakris G. (Chicago, Ill.)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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