Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/4376 |
Resumo: | The aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance to recombinant human erythropoietin (rhEPO) therapy. Methods: We studied 63 CKD patients under hemodialysis and rhEPO treatment (32 responders and 31 non-responders to rhEPO therapy). In 20 of the CKD patients (10 responders and 10 non-responders to rhEPO therapy), blood samples were also collected immediately after dialysis. Twenty-six healthy volunteers were included in a control group. Hemoglobin levels, total and differential leukocyte counts, and circulating levels of C-reactive protein (CRP), elastase and lactoferrin were measured in all patients and controls. Results: Compared with controls, CKD patients presented with significantly higher CRP, neutrophil and elastase levels. When we compared the 2 groups of patients, we found that non-responders presented statistically significantly higher elastase plasma levels. A positive significant correlation was found between elastase levels and weekly rhEPO dose and CRP serum levels. After the hemodialysis procedure, a statistically significant rise in elastase, lactoferrin and, elastase/neutrophil and lactoferrin/neutrophil ratios were found. Conclusions: Our data show that CKD patients under hemodialysis present higher elastase levels (particularly in non-responding patients), which could be related to the rise in neutrophils, and to be part of the enhanced inflammatory process found in these patients |
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Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis PatientsrhEPO therapy, resistanceNeutrophil activationElastaseLactoferrinThe aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance to recombinant human erythropoietin (rhEPO) therapy. Methods: We studied 63 CKD patients under hemodialysis and rhEPO treatment (32 responders and 31 non-responders to rhEPO therapy). In 20 of the CKD patients (10 responders and 10 non-responders to rhEPO therapy), blood samples were also collected immediately after dialysis. Twenty-six healthy volunteers were included in a control group. Hemoglobin levels, total and differential leukocyte counts, and circulating levels of C-reactive protein (CRP), elastase and lactoferrin were measured in all patients and controls. Results: Compared with controls, CKD patients presented with significantly higher CRP, neutrophil and elastase levels. When we compared the 2 groups of patients, we found that non-responders presented statistically significantly higher elastase plasma levels. A positive significant correlation was found between elastase levels and weekly rhEPO dose and CRP serum levels. After the hemodialysis procedure, a statistically significant rise in elastase, lactoferrin and, elastase/neutrophil and lactoferrin/neutrophil ratios were found. Conclusions: Our data show that CKD patients under hemodialysis present higher elastase levels (particularly in non-responding patients), which could be related to the rise in neutrophils, and to be part of the enhanced inflammatory process found in these patientsBakris G. (Chicago, Ill.)Veritati - Repositório Institucional da Universidade Católica PortuguesaCosta, ElísioRocha, SusanaRocha-Pereira, PetronilaNascimento, HenriqueCastro, ElisabethMiranda, VascoFaria, Maria do SameiroLoureiro, AlfredoBelo, LuísSantos-Silva, Alice2011-06-03T14:32:13Z20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/4376engCOSTA, Elísio - Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients.American Journal of Nephrology. ISSN 0250-8095. Vol.28 (2008) p. 935-94010.1159/000142147info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-26T01:40:10Zoai:repositorio.ucp.pt:10400.14/4376Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:05:45.906265Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients |
title |
Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients |
spellingShingle |
Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients Costa, Elísio rhEPO therapy, resistance Neutrophil activation Elastase Lactoferrin |
title_short |
Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients |
title_full |
Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients |
title_fullStr |
Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients |
title_full_unstemmed |
Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients |
title_sort |
Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients |
author |
Costa, Elísio |
author_facet |
Costa, Elísio Rocha, Susana Rocha-Pereira, Petronila Nascimento, Henrique Castro, Elisabeth Miranda, Vasco Faria, Maria do Sameiro Loureiro, Alfredo Belo, Luís Santos-Silva, Alice |
author_role |
author |
author2 |
Rocha, Susana Rocha-Pereira, Petronila Nascimento, Henrique Castro, Elisabeth Miranda, Vasco Faria, Maria do Sameiro Loureiro, Alfredo Belo, Luís Santos-Silva, Alice |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Costa, Elísio Rocha, Susana Rocha-Pereira, Petronila Nascimento, Henrique Castro, Elisabeth Miranda, Vasco Faria, Maria do Sameiro Loureiro, Alfredo Belo, Luís Santos-Silva, Alice |
dc.subject.por.fl_str_mv |
rhEPO therapy, resistance Neutrophil activation Elastase Lactoferrin |
topic |
rhEPO therapy, resistance Neutrophil activation Elastase Lactoferrin |
description |
The aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance to recombinant human erythropoietin (rhEPO) therapy. Methods: We studied 63 CKD patients under hemodialysis and rhEPO treatment (32 responders and 31 non-responders to rhEPO therapy). In 20 of the CKD patients (10 responders and 10 non-responders to rhEPO therapy), blood samples were also collected immediately after dialysis. Twenty-six healthy volunteers were included in a control group. Hemoglobin levels, total and differential leukocyte counts, and circulating levels of C-reactive protein (CRP), elastase and lactoferrin were measured in all patients and controls. Results: Compared with controls, CKD patients presented with significantly higher CRP, neutrophil and elastase levels. When we compared the 2 groups of patients, we found that non-responders presented statistically significantly higher elastase plasma levels. A positive significant correlation was found between elastase levels and weekly rhEPO dose and CRP serum levels. After the hemodialysis procedure, a statistically significant rise in elastase, lactoferrin and, elastase/neutrophil and lactoferrin/neutrophil ratios were found. Conclusions: Our data show that CKD patients under hemodialysis present higher elastase levels (particularly in non-responding patients), which could be related to the rise in neutrophils, and to be part of the enhanced inflammatory process found in these patients |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 2008-01-01T00:00:00Z 2011-06-03T14:32:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/4376 |
url |
http://hdl.handle.net/10400.14/4376 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
COSTA, Elísio - Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients.American Journal of Nephrology. ISSN 0250-8095. Vol.28 (2008) p. 935-940 10.1159/000142147 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Bakris G. (Chicago, Ill.) |
publisher.none.fl_str_mv |
Bakris G. (Chicago, Ill.) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131723433246720 |