Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping

Detalhes bibliográficos
Autor(a) principal: Piloto, N.
Data de Publicação: 2010
Outros Autores: Teixeira, HM, Garrido, P., Teixeira-Lemos, E., Teixeira, M., Parada, B., Sereno, J., Pinto, R ., Alves, R., Santos, P., Romão, AM, Nunes, S., Neto, P., Carvalho, L., Couceiro, P., Xavier, F., Rocha-Pereira, P., Costa, Elísio, Belo, L., Santos-Silva, A., Teixeira, F., Reis, F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/4375
Resumo: Recombinant human erythropoietin (rhEPO) has been therapeutically used for correction of anaemia. However, due to the increase in circulating red blood cells (RBCs) it promotes, thus increasing oxygen delivery to muscles and improving performance in sport, it has been also illegally used as sports doping. Besides the well known increase of hematocrit and blood viscosity; which might cause serious complications for the athletes, other disturbances could occur, whose mechanisms remain to be fully elucidated. This study aimed to evaluate the hemorheological and cardiovascular effects of administration of rhEPO to rats under chronic aerobic exercise. A ten week-protocol was performed in four male Wistar rat groups: control — sedentary; rhEPO — 50 IV/kg, 3 times/wk; exercised (EX) — swimming for 1 hr, 3 times/ wk; EX+rhEPO. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertro-phy, sympathetic and serotonergic overactivation, as well as a trend to increased oxidative stress. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected increased hematocrit, but also other serious deleterious cardiovascular and thromboembolic modifications, including live risk, which might be known and assumed by all sports authorities, including athletes and their physicians.
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spelling Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports dopingEfeitos hemorreológicos e cardiovasculares da eritropoietina num modelo de rato em exercício físico sob a acção de drogasrhEPODopingChronic aerobic exerciseHemorheological and cardiovascular (effects)Recombinant human erythropoietin (rhEPO) has been therapeutically used for correction of anaemia. However, due to the increase in circulating red blood cells (RBCs) it promotes, thus increasing oxygen delivery to muscles and improving performance in sport, it has been also illegally used as sports doping. Besides the well known increase of hematocrit and blood viscosity; which might cause serious complications for the athletes, other disturbances could occur, whose mechanisms remain to be fully elucidated. This study aimed to evaluate the hemorheological and cardiovascular effects of administration of rhEPO to rats under chronic aerobic exercise. A ten week-protocol was performed in four male Wistar rat groups: control — sedentary; rhEPO — 50 IV/kg, 3 times/wk; exercised (EX) — swimming for 1 hr, 3 times/ wk; EX+rhEPO. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertro-phy, sympathetic and serotonergic overactivation, as well as a trend to increased oxidative stress. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected increased hematocrit, but also other serious deleterious cardiovascular and thromboembolic modifications, including live risk, which might be known and assumed by all sports authorities, including athletes and their physicians.Sociedade Portuguesa de Hemorreologia e MicrocirculaçãoVeritati - Repositório Institucional da Universidade Católica PortuguesaPiloto, N.Teixeira, HMGarrido, P.Teixeira-Lemos, E.Teixeira, M.Parada, B.Sereno, J.Pinto, R .Alves, R.Santos, P.Romão, AMNunes, S.Neto, P.Carvalho, L.Couceiro, P.Xavier, F.Rocha-Pereira, P.Costa, ElísioBelo, L.Santos-Silva, A.Teixeira, F.Reis, F.2011-06-03T14:25:18Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/4375engPILOTO, N... [et al.] - Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping. Boletim Sociedade da Portuguesa de Hemorreologia e Microcirculação. ISSN 0872-4938.Vol. 25, n.º 1 (2010), p. 11 - 22.0872-4938info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:10:30Zoai:repositorio.ucp.pt:10400.14/4375Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:05:46.220322Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
Efeitos hemorreológicos e cardiovasculares da eritropoietina num modelo de rato em exercício físico sob a acção de drogas
title Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
spellingShingle Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
Piloto, N.
rhEPO
Doping
Chronic aerobic exercise
Hemorheological and cardiovascular (effects)
title_short Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
title_full Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
title_fullStr Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
title_full_unstemmed Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
title_sort Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
author Piloto, N.
author_facet Piloto, N.
Teixeira, HM
Garrido, P.
Teixeira-Lemos, E.
Teixeira, M.
Parada, B.
Sereno, J.
Pinto, R .
Alves, R.
Santos, P.
Romão, AM
Nunes, S.
Neto, P.
Carvalho, L.
Couceiro, P.
Xavier, F.
Rocha-Pereira, P.
Costa, Elísio
Belo, L.
Santos-Silva, A.
Teixeira, F.
Reis, F.
author_role author
author2 Teixeira, HM
Garrido, P.
Teixeira-Lemos, E.
Teixeira, M.
Parada, B.
Sereno, J.
Pinto, R .
Alves, R.
Santos, P.
Romão, AM
Nunes, S.
Neto, P.
Carvalho, L.
Couceiro, P.
Xavier, F.
Rocha-Pereira, P.
Costa, Elísio
Belo, L.
Santos-Silva, A.
Teixeira, F.
Reis, F.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Piloto, N.
Teixeira, HM
Garrido, P.
Teixeira-Lemos, E.
Teixeira, M.
Parada, B.
Sereno, J.
Pinto, R .
Alves, R.
Santos, P.
Romão, AM
Nunes, S.
Neto, P.
Carvalho, L.
Couceiro, P.
Xavier, F.
Rocha-Pereira, P.
Costa, Elísio
Belo, L.
Santos-Silva, A.
Teixeira, F.
Reis, F.
dc.subject.por.fl_str_mv rhEPO
Doping
Chronic aerobic exercise
Hemorheological and cardiovascular (effects)
topic rhEPO
Doping
Chronic aerobic exercise
Hemorheological and cardiovascular (effects)
description Recombinant human erythropoietin (rhEPO) has been therapeutically used for correction of anaemia. However, due to the increase in circulating red blood cells (RBCs) it promotes, thus increasing oxygen delivery to muscles and improving performance in sport, it has been also illegally used as sports doping. Besides the well known increase of hematocrit and blood viscosity; which might cause serious complications for the athletes, other disturbances could occur, whose mechanisms remain to be fully elucidated. This study aimed to evaluate the hemorheological and cardiovascular effects of administration of rhEPO to rats under chronic aerobic exercise. A ten week-protocol was performed in four male Wistar rat groups: control — sedentary; rhEPO — 50 IV/kg, 3 times/wk; exercised (EX) — swimming for 1 hr, 3 times/ wk; EX+rhEPO. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertro-phy, sympathetic and serotonergic overactivation, as well as a trend to increased oxidative stress. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected increased hematocrit, but also other serious deleterious cardiovascular and thromboembolic modifications, including live risk, which might be known and assumed by all sports authorities, including athletes and their physicians.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
2011-06-03T14:25:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/4375
url http://hdl.handle.net/10400.14/4375
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PILOTO, N... [et al.] - Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping. Boletim Sociedade da Portuguesa de Hemorreologia e Microcirculação. ISSN 0872-4938.Vol. 25, n.º 1 (2010), p. 11 - 22.
0872-4938
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Hemorreologia e Microcirculação
publisher.none.fl_str_mv Sociedade Portuguesa de Hemorreologia e Microcirculação
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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