Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/4375 |
Resumo: | Recombinant human erythropoietin (rhEPO) has been therapeutically used for correction of anaemia. However, due to the increase in circulating red blood cells (RBCs) it promotes, thus increasing oxygen delivery to muscles and improving performance in sport, it has been also illegally used as sports doping. Besides the well known increase of hematocrit and blood viscosity; which might cause serious complications for the athletes, other disturbances could occur, whose mechanisms remain to be fully elucidated. This study aimed to evaluate the hemorheological and cardiovascular effects of administration of rhEPO to rats under chronic aerobic exercise. A ten week-protocol was performed in four male Wistar rat groups: control — sedentary; rhEPO — 50 IV/kg, 3 times/wk; exercised (EX) — swimming for 1 hr, 3 times/ wk; EX+rhEPO. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertro-phy, sympathetic and serotonergic overactivation, as well as a trend to increased oxidative stress. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected increased hematocrit, but also other serious deleterious cardiovascular and thromboembolic modifications, including live risk, which might be known and assumed by all sports authorities, including athletes and their physicians. |
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Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports dopingEfeitos hemorreológicos e cardiovasculares da eritropoietina num modelo de rato em exercício físico sob a acção de drogasrhEPODopingChronic aerobic exerciseHemorheological and cardiovascular (effects)Recombinant human erythropoietin (rhEPO) has been therapeutically used for correction of anaemia. However, due to the increase in circulating red blood cells (RBCs) it promotes, thus increasing oxygen delivery to muscles and improving performance in sport, it has been also illegally used as sports doping. Besides the well known increase of hematocrit and blood viscosity; which might cause serious complications for the athletes, other disturbances could occur, whose mechanisms remain to be fully elucidated. This study aimed to evaluate the hemorheological and cardiovascular effects of administration of rhEPO to rats under chronic aerobic exercise. A ten week-protocol was performed in four male Wistar rat groups: control — sedentary; rhEPO — 50 IV/kg, 3 times/wk; exercised (EX) — swimming for 1 hr, 3 times/ wk; EX+rhEPO. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertro-phy, sympathetic and serotonergic overactivation, as well as a trend to increased oxidative stress. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected increased hematocrit, but also other serious deleterious cardiovascular and thromboembolic modifications, including live risk, which might be known and assumed by all sports authorities, including athletes and their physicians.Sociedade Portuguesa de Hemorreologia e MicrocirculaçãoVeritati - Repositório Institucional da Universidade Católica PortuguesaPiloto, N.Teixeira, HMGarrido, P.Teixeira-Lemos, E.Teixeira, M.Parada, B.Sereno, J.Pinto, R .Alves, R.Santos, P.Romão, AMNunes, S.Neto, P.Carvalho, L.Couceiro, P.Xavier, F.Rocha-Pereira, P.Costa, ElísioBelo, L.Santos-Silva, A.Teixeira, F.Reis, F.2011-06-03T14:25:18Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/4375engPILOTO, N... [et al.] - Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping. Boletim Sociedade da Portuguesa de Hemorreologia e Microcirculação. ISSN 0872-4938.Vol. 25, n.º 1 (2010), p. 11 - 22.0872-4938info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:10:30Zoai:repositorio.ucp.pt:10400.14/4375Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:05:46.220322Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping Efeitos hemorreológicos e cardiovasculares da eritropoietina num modelo de rato em exercício físico sob a acção de drogas |
title |
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping |
spellingShingle |
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping Piloto, N. rhEPO Doping Chronic aerobic exercise Hemorheological and cardiovascular (effects) |
title_short |
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping |
title_full |
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping |
title_fullStr |
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping |
title_full_unstemmed |
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping |
title_sort |
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping |
author |
Piloto, N. |
author_facet |
Piloto, N. Teixeira, HM Garrido, P. Teixeira-Lemos, E. Teixeira, M. Parada, B. Sereno, J. Pinto, R . Alves, R. Santos, P. Romão, AM Nunes, S. Neto, P. Carvalho, L. Couceiro, P. Xavier, F. Rocha-Pereira, P. Costa, Elísio Belo, L. Santos-Silva, A. Teixeira, F. Reis, F. |
author_role |
author |
author2 |
Teixeira, HM Garrido, P. Teixeira-Lemos, E. Teixeira, M. Parada, B. Sereno, J. Pinto, R . Alves, R. Santos, P. Romão, AM Nunes, S. Neto, P. Carvalho, L. Couceiro, P. Xavier, F. Rocha-Pereira, P. Costa, Elísio Belo, L. Santos-Silva, A. Teixeira, F. Reis, F. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Piloto, N. Teixeira, HM Garrido, P. Teixeira-Lemos, E. Teixeira, M. Parada, B. Sereno, J. Pinto, R . Alves, R. Santos, P. Romão, AM Nunes, S. Neto, P. Carvalho, L. Couceiro, P. Xavier, F. Rocha-Pereira, P. Costa, Elísio Belo, L. Santos-Silva, A. Teixeira, F. Reis, F. |
dc.subject.por.fl_str_mv |
rhEPO Doping Chronic aerobic exercise Hemorheological and cardiovascular (effects) |
topic |
rhEPO Doping Chronic aerobic exercise Hemorheological and cardiovascular (effects) |
description |
Recombinant human erythropoietin (rhEPO) has been therapeutically used for correction of anaemia. However, due to the increase in circulating red blood cells (RBCs) it promotes, thus increasing oxygen delivery to muscles and improving performance in sport, it has been also illegally used as sports doping. Besides the well known increase of hematocrit and blood viscosity; which might cause serious complications for the athletes, other disturbances could occur, whose mechanisms remain to be fully elucidated. This study aimed to evaluate the hemorheological and cardiovascular effects of administration of rhEPO to rats under chronic aerobic exercise. A ten week-protocol was performed in four male Wistar rat groups: control — sedentary; rhEPO — 50 IV/kg, 3 times/wk; exercised (EX) — swimming for 1 hr, 3 times/ wk; EX+rhEPO. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertro-phy, sympathetic and serotonergic overactivation, as well as a trend to increased oxidative stress. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected increased hematocrit, but also other serious deleterious cardiovascular and thromboembolic modifications, including live risk, which might be known and assumed by all sports authorities, including athletes and their physicians. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2010-01-01T00:00:00Z 2011-06-03T14:25:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/4375 |
url |
http://hdl.handle.net/10400.14/4375 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PILOTO, N... [et al.] - Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping. Boletim Sociedade da Portuguesa de Hemorreologia e Microcirculação. ISSN 0872-4938.Vol. 25, n.º 1 (2010), p. 11 - 22. 0872-4938 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Hemorreologia e Microcirculação |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Hemorreologia e Microcirculação |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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