Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal

Detalhes bibliográficos
Autor(a) principal: Borges, Vítor
Data de Publicação: 2023
Outros Autores: Duque, Mariana Perez, Martins, João Vieira, Vasconcelos, Paula, Ferreira, Rita, Sobral, Daniel, Pelerito, Ana, de Carvalho, Isabel Lopes, Núncio, Maria Sofia, Borrego, Maria José, Roemer, Cornelius, Neher, Richard A., O’Driscoll, Megan, Rocha, Raquel, Lopo, Sílvia, Neves, Raquel, Palminha, Paula, Coelho, Luís, Nunes, Alexandra, Isidro, Joana, Pinto, Miguel, Santos, João Dourado, Mixão, Verónica, Santos, Daniela, Duarte, Silvia, Vieira, Luís, Martins, Fátima, Machado, Jorge, Veríssimo, Vítor Cabral, Grau, Berta, Peralta-Santos, André, Neves, José, Caldeira, Margarida, Pestana, Mafalda, Fernandes, Cândida, Caria, João, Pinto, Raquel, Póvoas, Diana, Maltez, Fernando, Sá, Ana Isabel, Salvador, Mafalda Brito, Teófilo, Eugénio, Rocha, Miguel, Moneti, Virginia, Duque, Luis Miguel, e Silva, Francisco Ferreira, Baptista, Teresa, Vasconcelos, Joana, Casanova, Sara, Mansinho, Kamal, Alves, João Vaz, Alves, João, Silva, António, Alpalhão, Miguel, Brazão, Cláudia, Sousa, Diogo, Filipe, Paulo, Pacheco, Patrícia, Peruzzu, Francesca, de Jesus, Rita Patrocínio, Ferreira, Luís, Mendez, Josefina, Jordão, Sofia, Duarte, Frederico, Gonçalves, Maria João, Pena, Eduarda, Silva, Claúdio Nunes, Guimarães, André Rodrigues, Tavares, Margarida, Freitas, Graça, Cordeiro, Rita, Gomes, João Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8652
Resumo: Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/
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spelling Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in PortugalMpox VirusMPXVViral ZoonosisOutbreakGenomic EpidemiologyViral Genome SequencePortugalInfectious DiseasesInfecções Sistémicas e ZoonosesInfecções EmergentesFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal. We estimated a 62% infection reporting rate and that 1.3% of the population of men who have sex with men in Portugal were infected. We infer the critical role played by sexual networks and superspreader gatherings, such as sauna attendance, in the dissemination of mpox virus. Overall, our findings highlight genomic epidemiology as a tool for the real-time monitoring and control of mpox epidemics, and can guide future vaccine policy in a highly susceptible population.Springer NatureRepositório Científico do Instituto Nacional de SaúdeBorges, VítorDuque, Mariana PerezMartins, João VieiraVasconcelos, PaulaFerreira, RitaSobral, DanielPelerito, Anade Carvalho, Isabel LopesNúncio, Maria SofiaBorrego, Maria JoséRoemer, CorneliusNeher, Richard A.O’Driscoll, MeganRocha, RaquelLopo, SílviaNeves, RaquelPalminha, PaulaCoelho, LuísNunes, AlexandraIsidro, JoanaPinto, MiguelSantos, João DouradoMixão, VerónicaSantos, DanielaDuarte, SilviaVieira, LuísMartins, FátimaMachado, JorgeVeríssimo, Vítor CabralGrau, BertaPeralta-Santos, AndréNeves, JoséCaldeira, MargaridaPestana, MafaldaFernandes, CândidaCaria, JoãoPinto, RaquelPóvoas, DianaMaltez, FernandoSá, Ana IsabelSalvador, Mafalda BritoTeófilo, EugénioRocha, MiguelMoneti, VirginiaDuque, Luis Miguele Silva, Francisco FerreiraBaptista, TeresaVasconcelos, JoanaCasanova, SaraMansinho, KamalAlves, João VazAlves, JoãoSilva, AntónioAlpalhão, MiguelBrazão, CláudiaSousa, DiogoFilipe, PauloPacheco, PatríciaPeruzzu, Francescade Jesus, Rita PatrocínioFerreira, LuísMendez, JosefinaJordão, SofiaDuarte, FredericoGonçalves, Maria JoãoPena, EduardaSilva, Claúdio NunesGuimarães, André RodriguesTavares, MargaridaFreitas, GraçaCordeiro, RitaGomes, João Paulo2023-10-04T12:16:11Z2023-09-112023-09-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8652engNat Med. 2023 Sep 11. doi: 10.1038/s41591-023-02542-x. Online ahead of print.10.1038/s41591-023-02542-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-17T01:31:02Zoai:repositorio.insa.pt:10400.18/8652Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:33:35.008068Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
title Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
spellingShingle Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
Borges, Vítor
Mpox Virus
MPXV
Viral Zoonosis
Outbreak
Genomic Epidemiology
Viral Genome Sequence
Portugal
Infectious Diseases
Infecções Sistémicas e Zoonoses
Infecções Emergentes
title_short Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
title_full Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
title_fullStr Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
title_full_unstemmed Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
title_sort Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
author Borges, Vítor
author_facet Borges, Vítor
Duque, Mariana Perez
Martins, João Vieira
Vasconcelos, Paula
Ferreira, Rita
Sobral, Daniel
Pelerito, Ana
de Carvalho, Isabel Lopes
Núncio, Maria Sofia
Borrego, Maria José
Roemer, Cornelius
Neher, Richard A.
O’Driscoll, Megan
Rocha, Raquel
Lopo, Sílvia
Neves, Raquel
Palminha, Paula
Coelho, Luís
Nunes, Alexandra
Isidro, Joana
Pinto, Miguel
Santos, João Dourado
Mixão, Verónica
Santos, Daniela
Duarte, Silvia
Vieira, Luís
Martins, Fátima
Machado, Jorge
Veríssimo, Vítor Cabral
Grau, Berta
Peralta-Santos, André
Neves, José
Caldeira, Margarida
Pestana, Mafalda
Fernandes, Cândida
Caria, João
Pinto, Raquel
Póvoas, Diana
Maltez, Fernando
Sá, Ana Isabel
Salvador, Mafalda Brito
Teófilo, Eugénio
Rocha, Miguel
Moneti, Virginia
Duque, Luis Miguel
e Silva, Francisco Ferreira
Baptista, Teresa
Vasconcelos, Joana
Casanova, Sara
Mansinho, Kamal
Alves, João Vaz
Alves, João
Silva, António
Alpalhão, Miguel
Brazão, Cláudia
Sousa, Diogo
Filipe, Paulo
Pacheco, Patrícia
Peruzzu, Francesca
de Jesus, Rita Patrocínio
Ferreira, Luís
Mendez, Josefina
Jordão, Sofia
Duarte, Frederico
Gonçalves, Maria João
Pena, Eduarda
Silva, Claúdio Nunes
Guimarães, André Rodrigues
Tavares, Margarida
Freitas, Graça
Cordeiro, Rita
Gomes, João Paulo
author_role author
author2 Duque, Mariana Perez
Martins, João Vieira
Vasconcelos, Paula
Ferreira, Rita
Sobral, Daniel
Pelerito, Ana
de Carvalho, Isabel Lopes
Núncio, Maria Sofia
Borrego, Maria José
Roemer, Cornelius
Neher, Richard A.
O’Driscoll, Megan
Rocha, Raquel
Lopo, Sílvia
Neves, Raquel
Palminha, Paula
Coelho, Luís
Nunes, Alexandra
Isidro, Joana
Pinto, Miguel
Santos, João Dourado
Mixão, Verónica
Santos, Daniela
Duarte, Silvia
Vieira, Luís
Martins, Fátima
Machado, Jorge
Veríssimo, Vítor Cabral
Grau, Berta
Peralta-Santos, André
Neves, José
Caldeira, Margarida
Pestana, Mafalda
Fernandes, Cândida
Caria, João
Pinto, Raquel
Póvoas, Diana
Maltez, Fernando
Sá, Ana Isabel
Salvador, Mafalda Brito
Teófilo, Eugénio
Rocha, Miguel
Moneti, Virginia
Duque, Luis Miguel
e Silva, Francisco Ferreira
Baptista, Teresa
Vasconcelos, Joana
Casanova, Sara
Mansinho, Kamal
Alves, João Vaz
Alves, João
Silva, António
Alpalhão, Miguel
Brazão, Cláudia
Sousa, Diogo
Filipe, Paulo
Pacheco, Patrícia
Peruzzu, Francesca
de Jesus, Rita Patrocínio
Ferreira, Luís
Mendez, Josefina
Jordão, Sofia
Duarte, Frederico
Gonçalves, Maria João
Pena, Eduarda
Silva, Claúdio Nunes
Guimarães, André Rodrigues
Tavares, Margarida
Freitas, Graça
Cordeiro, Rita
Gomes, João Paulo
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dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Borges, Vítor
Duque, Mariana Perez
Martins, João Vieira
Vasconcelos, Paula
Ferreira, Rita
Sobral, Daniel
Pelerito, Ana
de Carvalho, Isabel Lopes
Núncio, Maria Sofia
Borrego, Maria José
Roemer, Cornelius
Neher, Richard A.
O’Driscoll, Megan
Rocha, Raquel
Lopo, Sílvia
Neves, Raquel
Palminha, Paula
Coelho, Luís
Nunes, Alexandra
Isidro, Joana
Pinto, Miguel
Santos, João Dourado
Mixão, Verónica
Santos, Daniela
Duarte, Silvia
Vieira, Luís
Martins, Fátima
Machado, Jorge
Veríssimo, Vítor Cabral
Grau, Berta
Peralta-Santos, André
Neves, José
Caldeira, Margarida
Pestana, Mafalda
Fernandes, Cândida
Caria, João
Pinto, Raquel
Póvoas, Diana
Maltez, Fernando
Sá, Ana Isabel
Salvador, Mafalda Brito
Teófilo, Eugénio
Rocha, Miguel
Moneti, Virginia
Duque, Luis Miguel
e Silva, Francisco Ferreira
Baptista, Teresa
Vasconcelos, Joana
Casanova, Sara
Mansinho, Kamal
Alves, João Vaz
Alves, João
Silva, António
Alpalhão, Miguel
Brazão, Cláudia
Sousa, Diogo
Filipe, Paulo
Pacheco, Patrícia
Peruzzu, Francesca
de Jesus, Rita Patrocínio
Ferreira, Luís
Mendez, Josefina
Jordão, Sofia
Duarte, Frederico
Gonçalves, Maria João
Pena, Eduarda
Silva, Claúdio Nunes
Guimarães, André Rodrigues
Tavares, Margarida
Freitas, Graça
Cordeiro, Rita
Gomes, João Paulo
dc.subject.por.fl_str_mv Mpox Virus
MPXV
Viral Zoonosis
Outbreak
Genomic Epidemiology
Viral Genome Sequence
Portugal
Infectious Diseases
Infecções Sistémicas e Zoonoses
Infecções Emergentes
topic Mpox Virus
MPXV
Viral Zoonosis
Outbreak
Genomic Epidemiology
Viral Genome Sequence
Portugal
Infectious Diseases
Infecções Sistémicas e Zoonoses
Infecções Emergentes
description Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/
publishDate 2023
dc.date.none.fl_str_mv 2023-10-04T12:16:11Z
2023-09-11
2023-09-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8652
url http://hdl.handle.net/10400.18/8652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nat Med. 2023 Sep 11. doi: 10.1038/s41591-023-02542-x. Online ahead of print.
10.1038/s41591-023-02542-x
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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