A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L

Detalhes bibliográficos
Autor(a) principal: Cvetanović, Aleksandra
Data de Publicação: 2018
Outros Autores: Zeković, Zoran, Švarc-Gajić, Jaroslava, Razić, Slavica, Damjanović, Ana, Zengin, Gokhan, Delerue-Matos, Cristina, Moreira, Manuela M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14715
Resumo: BACKGROUND To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSION Results obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against α‐amylase, α‐glucosidase and tyrosinase, and the results showed the anti‐diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A‐549; LS‐174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58–8.10 μg mL‐1. Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto‐pharmaceuticals and functional food ingredients. © 2017 Society of Chemical Industry
id RCAP_8f87f61db134d7277301eb86d9a19c51
oai_identifier_str oai:recipp.ipp.pt:10400.22/14715
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus LExtractionPharmaceuticalsSupercritical fluidsSubcritical water extractionPlantBACKGROUND To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSION Results obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against α‐amylase, α‐glucosidase and tyrosinase, and the results showed the anti‐diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A‐549; LS‐174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58–8.10 μg mL‐1. Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto‐pharmaceuticals and functional food ingredients. © 2017 Society of Chemical Industryhe present work is part of the research conducted within the bilateral cooperation between the Republic of Serbia and Portuguese Republic (Project No. 451‐03‐01765/2014‐09/28) and within the projects of the Serbian Ministry of Education, Science and Technological Development, (Projects No. TR31013, III43009 and 175011). Manuela M. Moreira (SFRH/BPD/97049/2013) is grateful for the postdoctoral fellowships financed by POPH‐QREN – Tipologia 4.1 – Formação Avançada, subsidized by Fundo Social Europeu and Ministério da Ciência, Tecnologia e Ensino Superior. The authors are also grateful for the financial support from FCT/MEC through national funds and co‐financed by FEDER, under the Partnership Agreement PT2020 through the project UID/ QUI/50006/2013 ‐ POCI/01/0145/FERDER/007265.Society of Chemical IndustryRepositório Científico do Instituto Politécnico do PortoCvetanović, AleksandraZeković, ZoranŠvarc-Gajić, JaroslavaRazić, SlavicaDamjanović, AnaZengin, GokhanDelerue-Matos, CristinaMoreira, Manuela M.2019-10-07T15:24:13Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14715eng10.1002/jctb.5468info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:57:44Zoai:recipp.ipp.pt:10400.22/14715Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:14.392921Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L
title A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L
spellingShingle A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L
Cvetanović, Aleksandra
Extraction
Pharmaceuticals
Supercritical fluids
Subcritical water extraction
Plant
title_short A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L
title_full A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L
title_fullStr A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L
title_full_unstemmed A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L
title_sort A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L
author Cvetanović, Aleksandra
author_facet Cvetanović, Aleksandra
Zeković, Zoran
Švarc-Gajić, Jaroslava
Razić, Slavica
Damjanović, Ana
Zengin, Gokhan
Delerue-Matos, Cristina
Moreira, Manuela M.
author_role author
author2 Zeković, Zoran
Švarc-Gajić, Jaroslava
Razić, Slavica
Damjanović, Ana
Zengin, Gokhan
Delerue-Matos, Cristina
Moreira, Manuela M.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Cvetanović, Aleksandra
Zeković, Zoran
Švarc-Gajić, Jaroslava
Razić, Slavica
Damjanović, Ana
Zengin, Gokhan
Delerue-Matos, Cristina
Moreira, Manuela M.
dc.subject.por.fl_str_mv Extraction
Pharmaceuticals
Supercritical fluids
Subcritical water extraction
Plant
topic Extraction
Pharmaceuticals
Supercritical fluids
Subcritical water extraction
Plant
description BACKGROUND To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSION Results obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against α‐amylase, α‐glucosidase and tyrosinase, and the results showed the anti‐diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A‐549; LS‐174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58–8.10 μg mL‐1. Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto‐pharmaceuticals and functional food ingredients. © 2017 Society of Chemical Industry
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-10-07T15:24:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14715
url http://hdl.handle.net/10400.22/14715
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1002/jctb.5468
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Society of Chemical Industry
publisher.none.fl_str_mv Society of Chemical Industry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799131434498129920

Registros relacionados