Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells

Detalhes bibliográficos
Autor(a) principal: Feliciano, Amélia
Data de Publicação: 2017
Outros Autores: Vaz, Fátima, Torres, Vukosava M., Valentim-Coelho, Cristina, Silva, Rita, Prosinecki, Vesna, Alexandre, Bruno M., Carvalho, Ana S., Matthiesen, Rune, Malhotra, Atul, Pinto, Paula, Bárbara, Cristina, Penque, Deborah
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/153237
Resumo: Funding: Project partially supported by Harvard Medical School-Portugal Program (HMSPICJ/0022/2011), ToxOmics - Centre for Toxicogenomics and Human Health (FCT-UID/BIM/00009/2013), FCT/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal) and postdoctoral fellowship (SFRH/BPD/43365/2008) of Fundação para a Ciência e a Tecnologia (FCT), Portugal.
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spelling Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cellsCorrelation with polysomnographic and metabolic parametersBiomarkersObstructive sleep apneaPeroxiredeoxin-2Red blood cellsMolecular MedicineMolecular BiologyFunding: Project partially supported by Harvard Medical School-Portugal Program (HMSPICJ/0022/2011), ToxOmics - Centre for Toxicogenomics and Human Health (FCT-UID/BIM/00009/2013), FCT/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal) and postdoctoral fellowship (SFRH/BPD/43365/2008) of Fundação para a Ciência e a Tecnologia (FCT), Portugal.We have examined the effects of Obstructive Sleep Apnea (OSA) on red blood cell (RBC) proteome variation at evening/morning day time to uncover new insights into OSA-induced RBC dysfunction that may lead to OSA manifestations. Dysregulated proteins mainly fall in the group of catalytic enzymes, stress response and redox regulators such as peroxiredoxin 2 (PRDX2). Validation assays confirmed that at morning the monomeric/dimeric forms of PRDX2 were more overoxidized in OSA RBC compared to evening samples. Six month of positive airway pressure (PAP) treatment decreased this overoxidation and generated multimeric overoxidized forms associated with chaperone/transduction signaling activity of PRDX2. Morning levels of overoxidized PRDX2 correlated with polysomnographic (PSG)-arousal index and metabolic parameters whereas the evening level of disulfide-linked dimer (associated with peroxidase activity of PRDX2) correlated with PSG parameters. After treatment, morning overoxidized multimer of PRDX2 negatively correlated with fasting glucose and dopamine levels. Overall, these data point toward severe oxidative stress and altered antioxidant homeostasis in OSA RBC occurring mainly at morning time but with consequences till evening. The beneficial effect of PAP involves modulation of the redox/oligomeric state of PRDX2, whose mechanism and associated chaperone/transduction signaling functions deserves further investigation. RBC PRDX2 is a promising candidate biomarker for OSA severity and treatment monitoring, warranting further investigation and validation.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFeliciano, AméliaVaz, FátimaTorres, Vukosava M.Valentim-Coelho, CristinaSilva, RitaProsinecki, VesnaAlexandre, Bruno M.Carvalho, Ana S.Matthiesen, RuneMalhotra, AtulPinto, PaulaBárbara, CristinaPenque, Deborah2023-05-26T22:22:20Z2017-02-012017-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/153237eng0925-4439PURE: 61692885https://doi.org/10.1016/j.bbadis.2016.11.019info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:35:51Zoai:run.unl.pt:10362/153237Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:14.106019Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells
Correlation with polysomnographic and metabolic parameters
title Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells
spellingShingle Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells
Feliciano, Amélia
Biomarkers
Obstructive sleep apnea
Peroxiredeoxin-2
Red blood cells
Molecular Medicine
Molecular Biology
title_short Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells
title_full Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells
title_fullStr Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells
title_full_unstemmed Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells
title_sort Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells
author Feliciano, Amélia
author_facet Feliciano, Amélia
Vaz, Fátima
Torres, Vukosava M.
Valentim-Coelho, Cristina
Silva, Rita
Prosinecki, Vesna
Alexandre, Bruno M.
Carvalho, Ana S.
Matthiesen, Rune
Malhotra, Atul
Pinto, Paula
Bárbara, Cristina
Penque, Deborah
author_role author
author2 Vaz, Fátima
Torres, Vukosava M.
Valentim-Coelho, Cristina
Silva, Rita
Prosinecki, Vesna
Alexandre, Bruno M.
Carvalho, Ana S.
Matthiesen, Rune
Malhotra, Atul
Pinto, Paula
Bárbara, Cristina
Penque, Deborah
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centre for Toxicogenomics and Human Health (ToxOmics)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Feliciano, Amélia
Vaz, Fátima
Torres, Vukosava M.
Valentim-Coelho, Cristina
Silva, Rita
Prosinecki, Vesna
Alexandre, Bruno M.
Carvalho, Ana S.
Matthiesen, Rune
Malhotra, Atul
Pinto, Paula
Bárbara, Cristina
Penque, Deborah
dc.subject.por.fl_str_mv Biomarkers
Obstructive sleep apnea
Peroxiredeoxin-2
Red blood cells
Molecular Medicine
Molecular Biology
topic Biomarkers
Obstructive sleep apnea
Peroxiredeoxin-2
Red blood cells
Molecular Medicine
Molecular Biology
description Funding: Project partially supported by Harvard Medical School-Portugal Program (HMSPICJ/0022/2011), ToxOmics - Centre for Toxicogenomics and Human Health (FCT-UID/BIM/00009/2013), FCT/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal) and postdoctoral fellowship (SFRH/BPD/43365/2008) of Fundação para a Ciência e a Tecnologia (FCT), Portugal.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
2017-02-01T00:00:00Z
2023-05-26T22:22:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/153237
url http://hdl.handle.net/10362/153237
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0925-4439
PURE: 61692885
https://doi.org/10.1016/j.bbadis.2016.11.019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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