Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome

Detalhes bibliográficos
Autor(a) principal: Feliciano, Amélia
Data de Publicação: 2017
Outros Autores: Vaz, Fátima, Valentim-Coelho, Cristina, Torres, Vukosava M., Silva, Rita, Prosinecki, Vesna, Alexandre, Bruno M., Almeida, Andreia, Almeida-Marques, Catarina, Carvalho, Ana S., Matthiesen, Rune, Malhotra, Atul, Pinto, Paula, Bárbara, Cristina, Penque, Deborah
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/153236
Resumo: Project partially supported by Harvard Medical School-Portugal Program (HMSP-ICJ/ 0022/2011), ToxOmics - Centre for Toxicogenomics and Human Health (FCT-UID/BIM/00009/2013), FCT/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal) and postdoctoral fellowship SFRH/BPD/43365/2008 of Fundação para a Ciência e a Tecnologia (FCT), Portugal.
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spelling Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome2D-DIGEBiomarkersObstructive Sleep ApneaRed blood cellsGeneralProject partially supported by Harvard Medical School-Portugal Program (HMSP-ICJ/ 0022/2011), ToxOmics - Centre for Toxicogenomics and Human Health (FCT-UID/BIM/00009/2013), FCT/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal) and postdoctoral fellowship SFRH/BPD/43365/2008 of Fundação para a Ciência e a Tecnologia (FCT), Portugal.This article presents proteomics data referenced in [1] Using proteomics-based evaluation of red blood cells (RBCs), we have identified differentially abundant proteins associated with Obstructive Sleep Apnea Syndrome (OSA). RBCs were collected from peripheral blood of patients with moderate/severe OSA or snoring at pre- (evening) and post-night (morning) polysomnography, so that proteome variations between these time points could be assessed. RBC cytoplasmic fraction depleted of hemoglobin, using Hemovoid™ system, were analyzed by two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), the 2D image software-based analyzed and relevant differentially abundant proteins identified by mass spectrometry (MS). MS identified 31 protein spots differentially abundant corresponding to 21 unique proteins possibly due to the existence of post-translational modification regulations. Functional analysis by bioinformatics tools indicated that most proteins are associated with catalytic, oxidoreductase, peroxidase, hydrolase, ATPase and anti-oxidant activity. At morning a larger numbers of differential proteins including response to chemical stimulus, oxidation reduction, regulation of catalytic activity and response to stress were observed in OSA. The data might support further research in OSA biomarker discovery and validation.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFeliciano, AméliaVaz, FátimaValentim-Coelho, CristinaTorres, Vukosava M.Silva, RitaProsinecki, VesnaAlexandre, Bruno M.Almeida, AndreiaAlmeida-Marques, CatarinaCarvalho, Ana S.Matthiesen, RuneMalhotra, AtulPinto, PaulaBárbara, CristinaPenque, Deborah2023-05-26T22:22:16Z2017-04-012017-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/153236eng2352-3409PURE: 61690343https://doi.org/10.1016/j.dib.2017.01.005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:35:51Zoai:run.unl.pt:10362/153236Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:14.037156Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome
title Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome
spellingShingle Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome
Feliciano, Amélia
2D-DIGE
Biomarkers
Obstructive Sleep Apnea
Red blood cells
General
title_short Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome
title_full Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome
title_fullStr Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome
title_full_unstemmed Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome
title_sort Evening and morning alterations in Obstructive Sleep Apnea red blood cell proteome
author Feliciano, Amélia
author_facet Feliciano, Amélia
Vaz, Fátima
Valentim-Coelho, Cristina
Torres, Vukosava M.
Silva, Rita
Prosinecki, Vesna
Alexandre, Bruno M.
Almeida, Andreia
Almeida-Marques, Catarina
Carvalho, Ana S.
Matthiesen, Rune
Malhotra, Atul
Pinto, Paula
Bárbara, Cristina
Penque, Deborah
author_role author
author2 Vaz, Fátima
Valentim-Coelho, Cristina
Torres, Vukosava M.
Silva, Rita
Prosinecki, Vesna
Alexandre, Bruno M.
Almeida, Andreia
Almeida-Marques, Catarina
Carvalho, Ana S.
Matthiesen, Rune
Malhotra, Atul
Pinto, Paula
Bárbara, Cristina
Penque, Deborah
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centre for Toxicogenomics and Human Health (ToxOmics)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Feliciano, Amélia
Vaz, Fátima
Valentim-Coelho, Cristina
Torres, Vukosava M.
Silva, Rita
Prosinecki, Vesna
Alexandre, Bruno M.
Almeida, Andreia
Almeida-Marques, Catarina
Carvalho, Ana S.
Matthiesen, Rune
Malhotra, Atul
Pinto, Paula
Bárbara, Cristina
Penque, Deborah
dc.subject.por.fl_str_mv 2D-DIGE
Biomarkers
Obstructive Sleep Apnea
Red blood cells
General
topic 2D-DIGE
Biomarkers
Obstructive Sleep Apnea
Red blood cells
General
description Project partially supported by Harvard Medical School-Portugal Program (HMSP-ICJ/ 0022/2011), ToxOmics - Centre for Toxicogenomics and Human Health (FCT-UID/BIM/00009/2013), FCT/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal) and postdoctoral fellowship SFRH/BPD/43365/2008 of Fundação para a Ciência e a Tecnologia (FCT), Portugal.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-01
2017-04-01T00:00:00Z
2023-05-26T22:22:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/153236
url http://hdl.handle.net/10362/153236
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2352-3409
PURE: 61690343
https://doi.org/10.1016/j.dib.2017.01.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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