Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected

Detalhes bibliográficos
Autor(a) principal: Abreu, C
Data de Publicação: 2016
Outros Autores: Silva-Pinto, A, Lazzara, D, Sobrinho-Simões, J, Guimarães, JT, Sarmento, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/114766
Resumo: BACKGROUND:All the reports from Angola's 2013 dengue outbreak revealed serotype 1. However, previously dengue serotypes 1-4 have been reported in Africa and in 2014 serotype 4 was reported in Angola. OBJECTIVES:To report dengue serotypes in patients returning from Angola during 2013 outbreak. STUDY DESIGN:Retrospective, cross-sectional study. We serotyped the dengue by an in house Polymerase Chain Reaction technique in randomly selected cases. RESULTS:From the 2013 Angola's dengue outbreak we treated 47 adult patients. None had history of past dengue. A combo kit test for dengue revealed positive NS1 antigen in 39 and IgM antibodies in 8. From 17 randomly patients tested by RNA Real Time-PCR, 11 were positive: 7 for DENV-1, 2 for DENV-2, 1 for DENV-3 (co-infected with DENV-1) and 1 for DENV-4. None had a complicated or fatal evolution. CONCLUSION:Unlike previous reports the 4 serotypes were detected, and this resulted in a different epidemiological situation, raising the risk of future outbreaks of severe dengue.
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spelling Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detectedDengueDengue serotypeDengue outbreak - AngolaBACKGROUND:All the reports from Angola's 2013 dengue outbreak revealed serotype 1. However, previously dengue serotypes 1-4 have been reported in Africa and in 2014 serotype 4 was reported in Angola. OBJECTIVES:To report dengue serotypes in patients returning from Angola during 2013 outbreak. STUDY DESIGN:Retrospective, cross-sectional study. We serotyped the dengue by an in house Polymerase Chain Reaction technique in randomly selected cases. RESULTS:From the 2013 Angola's dengue outbreak we treated 47 adult patients. None had history of past dengue. A combo kit test for dengue revealed positive NS1 antigen in 39 and IgM antibodies in 8. From 17 randomly patients tested by RNA Real Time-PCR, 11 were positive: 7 for DENV-1, 2 for DENV-2, 1 for DENV-3 (co-infected with DENV-1) and 1 for DENV-4. None had a complicated or fatal evolution. CONCLUSION:Unlike previous reports the 4 serotypes were detected, and this resulted in a different epidemiological situation, raising the risk of future outbreaks of severe dengue.20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/114766eng1386-653210.1016/j.jcv.2016.04.011Abreu, CSilva-Pinto, ALazzara, DSobrinho-Simões, JGuimarães, JTSarmento, Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:27:08Zoai:repositorio-aberto.up.pt:10216/114766Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:24:01.864382Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected
title Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected
spellingShingle Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected
Abreu, C
Dengue
Dengue serotype
Dengue outbreak - Angola
title_short Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected
title_full Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected
title_fullStr Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected
title_full_unstemmed Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected
title_sort Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected
author Abreu, C
author_facet Abreu, C
Silva-Pinto, A
Lazzara, D
Sobrinho-Simões, J
Guimarães, JT
Sarmento, A
author_role author
author2 Silva-Pinto, A
Lazzara, D
Sobrinho-Simões, J
Guimarães, JT
Sarmento, A
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Abreu, C
Silva-Pinto, A
Lazzara, D
Sobrinho-Simões, J
Guimarães, JT
Sarmento, A
dc.subject.por.fl_str_mv Dengue
Dengue serotype
Dengue outbreak - Angola
topic Dengue
Dengue serotype
Dengue outbreak - Angola
description BACKGROUND:All the reports from Angola's 2013 dengue outbreak revealed serotype 1. However, previously dengue serotypes 1-4 have been reported in Africa and in 2014 serotype 4 was reported in Angola. OBJECTIVES:To report dengue serotypes in patients returning from Angola during 2013 outbreak. STUDY DESIGN:Retrospective, cross-sectional study. We serotyped the dengue by an in house Polymerase Chain Reaction technique in randomly selected cases. RESULTS:From the 2013 Angola's dengue outbreak we treated 47 adult patients. None had history of past dengue. A combo kit test for dengue revealed positive NS1 antigen in 39 and IgM antibodies in 8. From 17 randomly patients tested by RNA Real Time-PCR, 11 were positive: 7 for DENV-1, 2 for DENV-2, 1 for DENV-3 (co-infected with DENV-1) and 1 for DENV-4. None had a complicated or fatal evolution. CONCLUSION:Unlike previous reports the 4 serotypes were detected, and this resulted in a different epidemiological situation, raising the risk of future outbreaks of severe dengue.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/114766
url http://hdl.handle.net/10216/114766
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1386-6532
10.1016/j.jcv.2016.04.011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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