Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding

Detalhes bibliográficos
Autor(a) principal: Antunes, Marco António Ribeiro
Data de Publicação: 2013
Outros Autores: Pereira, Telmo Ribeiro Ramos, Cordeiro, João, Jacinto, António Alfredo Coelho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/21900
Resumo: We are grateful for funding from Fundacao para a Ciencia e a Tecnologia (SFRH/BD/41884/2007), Human Frontier Science Program (RGP/2007), and European Research Council (2007-StG-208631).
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spelling Coordinated waves of actomyosin flow and apical cell constriction immediately after woundingDROSOPHILA EMBRYOSMYOSIN-IITISSUE REGENERATIONACTIN CYTOSKELETONADHERENS JUNCTIONSGENE-EXPRESSIONMORPHOGENESISPOLARITYCLOSUREPATHWAYWe are grateful for funding from Fundacao para a Ciencia e a Tecnologia (SFRH/BD/41884/2007), Human Frontier Science Program (RGP/2007), and European Research Council (2007-StG-208631).Epithelial wound healing relies on tissue movements and cell shape changes. Our work shows that, immediately after wounding, there was a dramatic cytoskeleton remodeling consisting of a pulse of actomyosin filaments that assembled in cells around the wound edge and flowed from cell to cell toward the margin of the wound. We show that this actomyosin flow was regulated by Diaphanous and ROCK and that it elicited a wave of apical cell constriction that culminated in the formation of the leading edge actomyosin cable, a structure that is essential for wound closure. Calcium signaling played an important role in this process, as its intracellular concentration increased dramatically immediately after wounding, and down-regulation of transient receptor potential channel M, a stress-activated calcium channel, also impaired solin, protein, also impaired the wound response, indicating that cleaving the existing actin filament network is an important part of the cytoskeleton remodeling process.Centro de Estudos de Doenças Crónicas (CEDOC)RUNAntunes, Marco António RibeiroPereira, Telmo Ribeiro RamosCordeiro, JoãoJacinto, António Alfredo Coelho2017-07-10T22:00:42Z2013-01-012013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/21900eng0021-9525PURE: 233986https://doi.org/10.1083/jcb.201211039info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:09:00Zoai:run.unl.pt:10362/21900Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:01.934204Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding
title Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding
spellingShingle Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding
Antunes, Marco António Ribeiro
DROSOPHILA EMBRYOS
MYOSIN-II
TISSUE REGENERATION
ACTIN CYTOSKELETON
ADHERENS JUNCTIONS
GENE-EXPRESSION
MORPHOGENESIS
POLARITY
CLOSURE
PATHWAY
title_short Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding
title_full Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding
title_fullStr Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding
title_full_unstemmed Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding
title_sort Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding
author Antunes, Marco António Ribeiro
author_facet Antunes, Marco António Ribeiro
Pereira, Telmo Ribeiro Ramos
Cordeiro, João
Jacinto, António Alfredo Coelho
author_role author
author2 Pereira, Telmo Ribeiro Ramos
Cordeiro, João
Jacinto, António Alfredo Coelho
author2_role author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Antunes, Marco António Ribeiro
Pereira, Telmo Ribeiro Ramos
Cordeiro, João
Jacinto, António Alfredo Coelho
dc.subject.por.fl_str_mv DROSOPHILA EMBRYOS
MYOSIN-II
TISSUE REGENERATION
ACTIN CYTOSKELETON
ADHERENS JUNCTIONS
GENE-EXPRESSION
MORPHOGENESIS
POLARITY
CLOSURE
PATHWAY
topic DROSOPHILA EMBRYOS
MYOSIN-II
TISSUE REGENERATION
ACTIN CYTOSKELETON
ADHERENS JUNCTIONS
GENE-EXPRESSION
MORPHOGENESIS
POLARITY
CLOSURE
PATHWAY
description We are grateful for funding from Fundacao para a Ciencia e a Tecnologia (SFRH/BD/41884/2007), Human Frontier Science Program (RGP/2007), and European Research Council (2007-StG-208631).
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2013-01-01T00:00:00Z
2017-07-10T22:00:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/21900
url http://hdl.handle.net/10362/21900
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0021-9525
PURE: 233986
https://doi.org/10.1083/jcb.201211039
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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