Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/65609 |
Resumo: | A major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pancreatic -cells, being secreted in similar amounts as insulin. The biological activity of human C-peptide is instrumental in the prevention of diabetic neuropathy, nephropathy and other vascular complications. The main feature of type 1 diabetes mellitus is the lack of insulin and of C-peptide, but the progressive -cell loss is also observed in later stage of type 2 diabetes mellitus. C-peptide has multifaceted effects in animals and diabetic patients due to the activation of multiple cell signalling pathways, highlighting p38 mitogen-activated protein kinase and extracellular signalregulated kinase ½, Akt, as well as endothelial nitric oxide production. Recent works highlight the role of C-peptide in the prevention and amelioration of diabetes and also in organ-specific complications. Benefits of C-peptide in microangiopathy and vasculopathy have been shown through conservation of vascular function, and also in the prevention of endothelial cell death, microvascular permeability, neointima formation, and in vascular inflammation. Improvement of microvascular blood flow by replacing a physiological amount of C-peptide, in several tissues of diabetic animals and humans, mainly in nerve tissue, myocardium, skeletal muscle, and kidney has been described. A review of the multiple cell signalling pathways of human proinsulin C-peptide in vasculopathy protection is proposed, where the approaches to move beyond the state of the art in the development of innovative and effective therapeutic options of diabetic neuropathy and nephropathy are discussed. |
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Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protectiondiabetes mellitusC-peptidevasculopathydiabetic neuropathydiabetic nephropathyScience & TechnologyA major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pancreatic -cells, being secreted in similar amounts as insulin. The biological activity of human C-peptide is instrumental in the prevention of diabetic neuropathy, nephropathy and other vascular complications. The main feature of type 1 diabetes mellitus is the lack of insulin and of C-peptide, but the progressive -cell loss is also observed in later stage of type 2 diabetes mellitus. C-peptide has multifaceted effects in animals and diabetic patients due to the activation of multiple cell signalling pathways, highlighting p38 mitogen-activated protein kinase and extracellular signalregulated kinase ½, Akt, as well as endothelial nitric oxide production. Recent works highlight the role of C-peptide in the prevention and amelioration of diabetes and also in organ-specific complications. Benefits of C-peptide in microangiopathy and vasculopathy have been shown through conservation of vascular function, and also in the prevention of endothelial cell death, microvascular permeability, neointima formation, and in vascular inflammation. Improvement of microvascular blood flow by replacing a physiological amount of C-peptide, in several tissues of diabetic animals and humans, mainly in nerve tissue, myocardium, skeletal muscle, and kidney has been described. A review of the multiple cell signalling pathways of human proinsulin C-peptide in vasculopathy protection is proposed, where the approaches to move beyond the state of the art in the development of innovative and effective therapeutic options of diabetic neuropathy and nephropathy are discussed.The authors acknowledge the financial support received from Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project references M-ERA-NET/0004/2015-PAIRED and UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020. The authors acknowledge the support of the research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoSouto, Selma B.Campos, Joana R.Fangueiro, Joana F.Silva, Amélia M.Cicero, NicolaLucarini, MassimoDurazzo, AlessandraSantini, AntonelloSouto, Eliana B.2020-01-182020-01-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/65609engSouto, Selma B.; Campos, Joana R.; Fangueiro, Joana F.; Silva, Amélia M.; Cicero, Nicola; Lucarini, Massimo; Durazzo, Alessandra; Santini, Antonello; Souto, Eliana, Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection. International Journal of Molecular Sciences, 21(2), 645, 20201424-67831422-00671661-659610.3390/ijms2102064531963760https://www.mdpi.com/1422-0067/21/2/645info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:13Zoai:repositorium.sdum.uminho.pt:1822/65609Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:32:14.405417Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection |
title |
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection |
spellingShingle |
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection Souto, Selma B. diabetes mellitus C-peptide vasculopathy diabetic neuropathy diabetic nephropathy Science & Technology |
title_short |
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection |
title_full |
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection |
title_fullStr |
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection |
title_full_unstemmed |
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection |
title_sort |
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection |
author |
Souto, Selma B. |
author_facet |
Souto, Selma B. Campos, Joana R. Fangueiro, Joana F. Silva, Amélia M. Cicero, Nicola Lucarini, Massimo Durazzo, Alessandra Santini, Antonello Souto, Eliana B. |
author_role |
author |
author2 |
Campos, Joana R. Fangueiro, Joana F. Silva, Amélia M. Cicero, Nicola Lucarini, Massimo Durazzo, Alessandra Santini, Antonello Souto, Eliana B. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Souto, Selma B. Campos, Joana R. Fangueiro, Joana F. Silva, Amélia M. Cicero, Nicola Lucarini, Massimo Durazzo, Alessandra Santini, Antonello Souto, Eliana B. |
dc.subject.por.fl_str_mv |
diabetes mellitus C-peptide vasculopathy diabetic neuropathy diabetic nephropathy Science & Technology |
topic |
diabetes mellitus C-peptide vasculopathy diabetic neuropathy diabetic nephropathy Science & Technology |
description |
A major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pancreatic -cells, being secreted in similar amounts as insulin. The biological activity of human C-peptide is instrumental in the prevention of diabetic neuropathy, nephropathy and other vascular complications. The main feature of type 1 diabetes mellitus is the lack of insulin and of C-peptide, but the progressive -cell loss is also observed in later stage of type 2 diabetes mellitus. C-peptide has multifaceted effects in animals and diabetic patients due to the activation of multiple cell signalling pathways, highlighting p38 mitogen-activated protein kinase and extracellular signalregulated kinase ½, Akt, as well as endothelial nitric oxide production. Recent works highlight the role of C-peptide in the prevention and amelioration of diabetes and also in organ-specific complications. Benefits of C-peptide in microangiopathy and vasculopathy have been shown through conservation of vascular function, and also in the prevention of endothelial cell death, microvascular permeability, neointima formation, and in vascular inflammation. Improvement of microvascular blood flow by replacing a physiological amount of C-peptide, in several tissues of diabetic animals and humans, mainly in nerve tissue, myocardium, skeletal muscle, and kidney has been described. A review of the multiple cell signalling pathways of human proinsulin C-peptide in vasculopathy protection is proposed, where the approaches to move beyond the state of the art in the development of innovative and effective therapeutic options of diabetic neuropathy and nephropathy are discussed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-18 2020-01-18T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/65609 |
url |
http://hdl.handle.net/1822/65609 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Souto, Selma B.; Campos, Joana R.; Fangueiro, Joana F.; Silva, Amélia M.; Cicero, Nicola; Lucarini, Massimo; Durazzo, Alessandra; Santini, Antonello; Souto, Eliana, Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy protection. International Journal of Molecular Sciences, 21(2), 645, 2020 1424-6783 1422-0067 1661-6596 10.3390/ijms21020645 31963760 https://www.mdpi.com/1422-0067/21/2/645 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
dc.source.none.fl_str_mv |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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