Effect of farnesol on Candida dubliniensis morphogenesis

Detalhes bibliográficos
Autor(a) principal: Henriques, Mariana
Data de Publicação: 2007
Outros Autores: Martins, Margarida Isabel Barros Coelho, Azeredo, Joana, Oliveira, Rosário
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/6062
Resumo: Cell–cell signalling in Candida albicans is a known phenomenon and farnesol was identified as a quorum sensing molecule determining the yeast morphology. The aim of this work was to verify if farnesol had a similar effect on Candida dubliniensis, highlighting the effect of farnesol on Candida spp. morphogenesis. Methods and Results: Two different strains of C. dubliniensis and one of C. albicans were grown both in RPMI 1640 and in serum in the presence of absence of farnesol. At 150 μmol l -1 farnesol the growth rate of both Candida species was not affected. On the contrary, farnesol inhibited hyphae and pseudohyphae formation in C. dubliniensis. Conclusion: Farnesol seems to mediate cell morphology in both Candida species. Significance and Impact of the Study: The effect of farnesol on C. dubliniensis morphology was not reported previously.
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spelling Effect of farnesol on Candida dubliniensis morphogenesisCandida albicansCandida dubliniensisFarnesolHyphaeMorphology alterationPseudohyphaeScience & TechnologyCell–cell signalling in Candida albicans is a known phenomenon and farnesol was identified as a quorum sensing molecule determining the yeast morphology. The aim of this work was to verify if farnesol had a similar effect on Candida dubliniensis, highlighting the effect of farnesol on Candida spp. morphogenesis. Methods and Results: Two different strains of C. dubliniensis and one of C. albicans were grown both in RPMI 1640 and in serum in the presence of absence of farnesol. At 150 μmol l -1 farnesol the growth rate of both Candida species was not affected. On the contrary, farnesol inhibited hyphae and pseudohyphae formation in C. dubliniensis. Conclusion: Farnesol seems to mediate cell morphology in both Candida species. Significance and Impact of the Study: The effect of farnesol on C. dubliniensis morphology was not reported previously.Fundação para a Ciência e a Tecnologia (FCT)Blackwell PublishingUniversidade do MinhoHenriques, MarianaMartins, Margarida Isabel Barros CoelhoAzeredo, JoanaOliveira, Rosário2007-022007-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/6062eng"Letters in applied microbiology". ISSN 0266-8254. 44:2 (Febr. 2007) 199-205.0266-825410.1111/j.1472-765X.2006.02044.x17257261info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:38:44Zoai:repositorium.sdum.uminho.pt:1822/6062Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:35:15.032012Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of farnesol on Candida dubliniensis morphogenesis
title Effect of farnesol on Candida dubliniensis morphogenesis
spellingShingle Effect of farnesol on Candida dubliniensis morphogenesis
Henriques, Mariana
Candida albicans
Candida dubliniensis
Farnesol
Hyphae
Morphology alteration
Pseudohyphae
Science & Technology
title_short Effect of farnesol on Candida dubliniensis morphogenesis
title_full Effect of farnesol on Candida dubliniensis morphogenesis
title_fullStr Effect of farnesol on Candida dubliniensis morphogenesis
title_full_unstemmed Effect of farnesol on Candida dubliniensis morphogenesis
title_sort Effect of farnesol on Candida dubliniensis morphogenesis
author Henriques, Mariana
author_facet Henriques, Mariana
Martins, Margarida Isabel Barros Coelho
Azeredo, Joana
Oliveira, Rosário
author_role author
author2 Martins, Margarida Isabel Barros Coelho
Azeredo, Joana
Oliveira, Rosário
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Henriques, Mariana
Martins, Margarida Isabel Barros Coelho
Azeredo, Joana
Oliveira, Rosário
dc.subject.por.fl_str_mv Candida albicans
Candida dubliniensis
Farnesol
Hyphae
Morphology alteration
Pseudohyphae
Science & Technology
topic Candida albicans
Candida dubliniensis
Farnesol
Hyphae
Morphology alteration
Pseudohyphae
Science & Technology
description Cell–cell signalling in Candida albicans is a known phenomenon and farnesol was identified as a quorum sensing molecule determining the yeast morphology. The aim of this work was to verify if farnesol had a similar effect on Candida dubliniensis, highlighting the effect of farnesol on Candida spp. morphogenesis. Methods and Results: Two different strains of C. dubliniensis and one of C. albicans were grown both in RPMI 1640 and in serum in the presence of absence of farnesol. At 150 μmol l -1 farnesol the growth rate of both Candida species was not affected. On the contrary, farnesol inhibited hyphae and pseudohyphae formation in C. dubliniensis. Conclusion: Farnesol seems to mediate cell morphology in both Candida species. Significance and Impact of the Study: The effect of farnesol on C. dubliniensis morphology was not reported previously.
publishDate 2007
dc.date.none.fl_str_mv 2007-02
2007-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/6062
url http://hdl.handle.net/1822/6062
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Letters in applied microbiology". ISSN 0266-8254. 44:2 (Febr. 2007) 199-205.
0266-8254
10.1111/j.1472-765X.2006.02044.x
17257261
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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