A Case of Flexural Exanthema as a Presenting Sign for COVID-19

Detalhes bibliográficos
Autor(a) principal: Oliveira, Raquel
Data de Publicação: 2020
Outros Autores: Gonçalo, Margarida, Faria, Carlos, Donaire, David, Barbosa, Benilde, Cardoso, José Carlos, Julião, Maria José, Moura, José, Carvalho, Armando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.78.3.1248
Resumo: We report a case of a 84-year-old male hospitalized for bacterial pneumonia who, during hospitalization, developed a flexural exanthema in parallel with a positive swab for SARS-CoV-2. Supportive therapy was instituted, the rash disappeared in 7 days and the patient fully recovered. At the same time, two other cases of SARS-CoV-2 infection occurred in the same ward. Histopathology and immunohistochemistry of a skin biopsy showed a scarce predominantly perivascular lymphocytic infiltration in the upper dermis, predominantly by CD4+ T cells, a slight epidermotropism, spongiosis and focal parakeratosis, compatible with a viral exanthema or a maculopapular drug eruption. Patch testing with possible culprit drugs were negative. We seek to add value in understanding all the manifestations of SARS-CoV-2 infection and to draw attention to the importance of early identification of skin manifestations in association with COVID-19.
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spelling A Case of Flexural Exanthema as a Presenting Sign for COVID-19Um Caso de Exantema Flexural como Sinal de Apresentação de COVID-19Coronavirus InfectionsCOVID-19ExanthemaSARS-CoV-2COVID-19ExantemaInfecções por CoronavírusSARS-CoV-2We report a case of a 84-year-old male hospitalized for bacterial pneumonia who, during hospitalization, developed a flexural exanthema in parallel with a positive swab for SARS-CoV-2. Supportive therapy was instituted, the rash disappeared in 7 days and the patient fully recovered. At the same time, two other cases of SARS-CoV-2 infection occurred in the same ward. Histopathology and immunohistochemistry of a skin biopsy showed a scarce predominantly perivascular lymphocytic infiltration in the upper dermis, predominantly by CD4+ T cells, a slight epidermotropism, spongiosis and focal parakeratosis, compatible with a viral exanthema or a maculopapular drug eruption. Patch testing with possible culprit drugs were negative. We seek to add value in understanding all the manifestations of SARS-CoV-2 infection and to draw attention to the importance of early identification of skin manifestations in association with COVID-19.Os autores descrevem o caso de um homem de 84 anos hospitalizado por pneumonia bacteriana que foi posteriormente diagnosticado com COVID-19 e observado com exantema flexural. Com terapêutica de suporte o rash desapareceu em 7 dias e o doente recuperou completamente. Na mesma altura surgiram dois outros casos de infeção por SARS-CoV-2 na mesma enfermaria. O estudo histopatológico e imunopatológico de biópsia de pele mostrou um infiltrado inflamatório perivascular de predomínio linfoplasmocitário ligeiro na derme superficial, predominantemente CD4+, um ligeiro epidermotropismo, espongiose e paraqueratose focal, compatível com um exantema viral ou uma erupção maculopapular medicamentosa. Os autores pretendem contribuir para uma melhor compreensão das manifestações da infeção pelo SARS-CoV-2 e alertar para a importância da identificação precoce de alterações cutâneas possivelmente associadas a COVID-19.Sociedade Portuguesa de Dermatologia e Venereologia2020-09-27T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.78.3.1248oai:ojs.revista.spdv.com.pt:article/1248Journal of the Portuguese Society of Dermatology and Venereology; Vol 78 No 3 (2020): July - September; 273-276Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 78 n. 3 (2020): Julho - Setembro; 273-2762182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spdv.com.pt/index.php/spdv/article/view/1248https://doi.org/10.29021/spdv.78.3.1248https://revista.spdv.com.pt/index.php/spdv/article/view/1248/857Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereologyhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessOliveira, RaquelGonçalo, MargaridaFaria, CarlosDonaire, DavidBarbosa, BenildeCardoso, José CarlosJulião, Maria JoséMoura, JoséCarvalho, Armando2022-10-06T12:35:16Zoai:ojs.revista.spdv.com.pt:article/1248Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:17.512192Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Case of Flexural Exanthema as a Presenting Sign for COVID-19
Um Caso de Exantema Flexural como Sinal de Apresentação de COVID-19
title A Case of Flexural Exanthema as a Presenting Sign for COVID-19
spellingShingle A Case of Flexural Exanthema as a Presenting Sign for COVID-19
Oliveira, Raquel
Coronavirus Infections
COVID-19
Exanthema
SARS-CoV-2
COVID-19
Exantema
Infecções por Coronavírus
SARS-CoV-2
title_short A Case of Flexural Exanthema as a Presenting Sign for COVID-19
title_full A Case of Flexural Exanthema as a Presenting Sign for COVID-19
title_fullStr A Case of Flexural Exanthema as a Presenting Sign for COVID-19
title_full_unstemmed A Case of Flexural Exanthema as a Presenting Sign for COVID-19
title_sort A Case of Flexural Exanthema as a Presenting Sign for COVID-19
author Oliveira, Raquel
author_facet Oliveira, Raquel
Gonçalo, Margarida
Faria, Carlos
Donaire, David
Barbosa, Benilde
Cardoso, José Carlos
Julião, Maria José
Moura, José
Carvalho, Armando
author_role author
author2 Gonçalo, Margarida
Faria, Carlos
Donaire, David
Barbosa, Benilde
Cardoso, José Carlos
Julião, Maria José
Moura, José
Carvalho, Armando
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Raquel
Gonçalo, Margarida
Faria, Carlos
Donaire, David
Barbosa, Benilde
Cardoso, José Carlos
Julião, Maria José
Moura, José
Carvalho, Armando
dc.subject.por.fl_str_mv Coronavirus Infections
COVID-19
Exanthema
SARS-CoV-2
COVID-19
Exantema
Infecções por Coronavírus
SARS-CoV-2
topic Coronavirus Infections
COVID-19
Exanthema
SARS-CoV-2
COVID-19
Exantema
Infecções por Coronavírus
SARS-CoV-2
description We report a case of a 84-year-old male hospitalized for bacterial pneumonia who, during hospitalization, developed a flexural exanthema in parallel with a positive swab for SARS-CoV-2. Supportive therapy was instituted, the rash disappeared in 7 days and the patient fully recovered. At the same time, two other cases of SARS-CoV-2 infection occurred in the same ward. Histopathology and immunohistochemistry of a skin biopsy showed a scarce predominantly perivascular lymphocytic infiltration in the upper dermis, predominantly by CD4+ T cells, a slight epidermotropism, spongiosis and focal parakeratosis, compatible with a viral exanthema or a maculopapular drug eruption. Patch testing with possible culprit drugs were negative. We seek to add value in understanding all the manifestations of SARS-CoV-2 infection and to draw attention to the importance of early identification of skin manifestations in association with COVID-19.
publishDate 2020
dc.date.none.fl_str_mv 2020-09-27T00:00:00Z
dc.type.driver.fl_str_mv journal article
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.78.3.1248
oai:ojs.revista.spdv.com.pt:article/1248
url https://doi.org/10.29021/spdv.78.3.1248
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/1248
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/1248
https://doi.org/10.29021/spdv.78.3.1248
https://revista.spdv.com.pt/index.php/spdv/article/view/1248/857
dc.rights.driver.fl_str_mv Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereology
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereology
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 78 No 3 (2020): July - September; 273-276
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 78 n. 3 (2020): Julho - Setembro; 273-276
2182-2409
2182-2395
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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