A Case of Flexural Exanthema as a Presenting Sign for COVID-19
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.78.3.1248 |
Resumo: | We report a case of a 84-year-old male hospitalized for bacterial pneumonia who, during hospitalization, developed a flexural exanthema in parallel with a positive swab for SARS-CoV-2. Supportive therapy was instituted, the rash disappeared in 7 days and the patient fully recovered. At the same time, two other cases of SARS-CoV-2 infection occurred in the same ward. Histopathology and immunohistochemistry of a skin biopsy showed a scarce predominantly perivascular lymphocytic infiltration in the upper dermis, predominantly by CD4+ T cells, a slight epidermotropism, spongiosis and focal parakeratosis, compatible with a viral exanthema or a maculopapular drug eruption. Patch testing with possible culprit drugs were negative. We seek to add value in understanding all the manifestations of SARS-CoV-2 infection and to draw attention to the importance of early identification of skin manifestations in association with COVID-19. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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A Case of Flexural Exanthema as a Presenting Sign for COVID-19Um Caso de Exantema Flexural como Sinal de Apresentação de COVID-19Coronavirus InfectionsCOVID-19ExanthemaSARS-CoV-2COVID-19ExantemaInfecções por CoronavírusSARS-CoV-2We report a case of a 84-year-old male hospitalized for bacterial pneumonia who, during hospitalization, developed a flexural exanthema in parallel with a positive swab for SARS-CoV-2. Supportive therapy was instituted, the rash disappeared in 7 days and the patient fully recovered. At the same time, two other cases of SARS-CoV-2 infection occurred in the same ward. Histopathology and immunohistochemistry of a skin biopsy showed a scarce predominantly perivascular lymphocytic infiltration in the upper dermis, predominantly by CD4+ T cells, a slight epidermotropism, spongiosis and focal parakeratosis, compatible with a viral exanthema or a maculopapular drug eruption. Patch testing with possible culprit drugs were negative. We seek to add value in understanding all the manifestations of SARS-CoV-2 infection and to draw attention to the importance of early identification of skin manifestations in association with COVID-19.Os autores descrevem o caso de um homem de 84 anos hospitalizado por pneumonia bacteriana que foi posteriormente diagnosticado com COVID-19 e observado com exantema flexural. Com terapêutica de suporte o rash desapareceu em 7 dias e o doente recuperou completamente. Na mesma altura surgiram dois outros casos de infeção por SARS-CoV-2 na mesma enfermaria. O estudo histopatológico e imunopatológico de biópsia de pele mostrou um infiltrado inflamatório perivascular de predomínio linfoplasmocitário ligeiro na derme superficial, predominantemente CD4+, um ligeiro epidermotropismo, espongiose e paraqueratose focal, compatível com um exantema viral ou uma erupção maculopapular medicamentosa. Os autores pretendem contribuir para uma melhor compreensão das manifestações da infeção pelo SARS-CoV-2 e alertar para a importância da identificação precoce de alterações cutâneas possivelmente associadas a COVID-19.Sociedade Portuguesa de Dermatologia e Venereologia2020-09-27T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.78.3.1248oai:ojs.revista.spdv.com.pt:article/1248Journal of the Portuguese Society of Dermatology and Venereology; Vol 78 No 3 (2020): July - September; 273-276Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 78 n. 3 (2020): Julho - Setembro; 273-2762182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spdv.com.pt/index.php/spdv/article/view/1248https://doi.org/10.29021/spdv.78.3.1248https://revista.spdv.com.pt/index.php/spdv/article/view/1248/857Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereologyhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessOliveira, RaquelGonçalo, MargaridaFaria, CarlosDonaire, DavidBarbosa, BenildeCardoso, José CarlosJulião, Maria JoséMoura, JoséCarvalho, Armando2022-10-06T12:35:16Zoai:ojs.revista.spdv.com.pt:article/1248Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:17.512192Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A Case of Flexural Exanthema as a Presenting Sign for COVID-19 Um Caso de Exantema Flexural como Sinal de Apresentação de COVID-19 |
title |
A Case of Flexural Exanthema as a Presenting Sign for COVID-19 |
spellingShingle |
A Case of Flexural Exanthema as a Presenting Sign for COVID-19 Oliveira, Raquel Coronavirus Infections COVID-19 Exanthema SARS-CoV-2 COVID-19 Exantema Infecções por Coronavírus SARS-CoV-2 |
title_short |
A Case of Flexural Exanthema as a Presenting Sign for COVID-19 |
title_full |
A Case of Flexural Exanthema as a Presenting Sign for COVID-19 |
title_fullStr |
A Case of Flexural Exanthema as a Presenting Sign for COVID-19 |
title_full_unstemmed |
A Case of Flexural Exanthema as a Presenting Sign for COVID-19 |
title_sort |
A Case of Flexural Exanthema as a Presenting Sign for COVID-19 |
author |
Oliveira, Raquel |
author_facet |
Oliveira, Raquel Gonçalo, Margarida Faria, Carlos Donaire, David Barbosa, Benilde Cardoso, José Carlos Julião, Maria José Moura, José Carvalho, Armando |
author_role |
author |
author2 |
Gonçalo, Margarida Faria, Carlos Donaire, David Barbosa, Benilde Cardoso, José Carlos Julião, Maria José Moura, José Carvalho, Armando |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Raquel Gonçalo, Margarida Faria, Carlos Donaire, David Barbosa, Benilde Cardoso, José Carlos Julião, Maria José Moura, José Carvalho, Armando |
dc.subject.por.fl_str_mv |
Coronavirus Infections COVID-19 Exanthema SARS-CoV-2 COVID-19 Exantema Infecções por Coronavírus SARS-CoV-2 |
topic |
Coronavirus Infections COVID-19 Exanthema SARS-CoV-2 COVID-19 Exantema Infecções por Coronavírus SARS-CoV-2 |
description |
We report a case of a 84-year-old male hospitalized for bacterial pneumonia who, during hospitalization, developed a flexural exanthema in parallel with a positive swab for SARS-CoV-2. Supportive therapy was instituted, the rash disappeared in 7 days and the patient fully recovered. At the same time, two other cases of SARS-CoV-2 infection occurred in the same ward. Histopathology and immunohistochemistry of a skin biopsy showed a scarce predominantly perivascular lymphocytic infiltration in the upper dermis, predominantly by CD4+ T cells, a slight epidermotropism, spongiosis and focal parakeratosis, compatible with a viral exanthema or a maculopapular drug eruption. Patch testing with possible culprit drugs were negative. We seek to add value in understanding all the manifestations of SARS-CoV-2 infection and to draw attention to the importance of early identification of skin manifestations in association with COVID-19. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-27T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.78.3.1248 oai:ojs.revista.spdv.com.pt:article/1248 |
url |
https://doi.org/10.29021/spdv.78.3.1248 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/1248 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/1248 https://doi.org/10.29021/spdv.78.3.1248 https://revista.spdv.com.pt/index.php/spdv/article/view/1248/857 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereology https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereology https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 78 No 3 (2020): July - September; 273-276 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 78 n. 3 (2020): Julho - Setembro; 273-276 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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