Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/11465 |
Resumo: | Journal compilation © 2007 Blackwell Publishing Ltd, Clinical and Experimental Allergy © 2007 The Authors |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapyCD25brightFoxp3Regulatory T cellsSpecific immunotherapyVenom allergyJournal compilation © 2007 Blackwell Publishing Ltd, Clinical and Experimental Allergy © 2007 The AuthorsBACKGROUND: Venom immunotherapy (VIT) induces long-lasting immune tolerance to hymenoptera venom antigens, but the underlying mechanisms are not yet clarified. Regulatory T cells are thought to play an important role in allergic diseases and tolerance induction during specific immunotherapy. AIM: Characterize longitudinally the impact of VIT on the pool of circulating regulatory T cells. METHODS: Fourteen hymenoptera venom-allergic patients with severe reactions (grades III-IV) were studied before, 6 and 12 months after starting ultra-rush VIT. Freshly isolated peripheral blood mononuclear cells were surface stained with a panel of markers of T cell differentiation and intracellularly for CTLA-4 and Foxp3 and analysed by flow cytometry. foxp3 mRNA was quantified by real-time PCR. VIT responses were assessed by measuring specific IgG4 and IgE levels. Eleven individuals with no history of insect venom allergy were studied as controls. RESULTS: VIT induces a significant progressive increase in both the proportion and the absolute numbers of regulatory T cells defined as CD25bright and/or Foxp3+ CD4+ T cells. These changes are not related to alterations in the expression of activation markers or imbalances in the naïve/memory T cell compartments. foxp3 mRNA levels also increased significantly during VIT. Of note, the increase in circulating regulatory T cell counts significantly correlates with the venom-specific IgG4/IgE ratio shift. CONCLUSION: VIT is associated with a progressive expansion of circulating regulatory T cells, supporting a role for these cells in tolerance induction.APB and RSS received scholarships from GlaxoSmithKline and Fundação para a Ciência e Tecnologia, Portugal, respectively.Blackwell PublishingRepositório da Universidade de LisboaPereira-Santos, M. C.Baptista, A. P.Melo, A.Alves, R. R.Soares, R. S.Pedro, E.Pereira-Barbosa, M.Victorino, R. M. M.Sousa, A. E.2014-07-14T14:34:29Z20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/11465engClinical and Experimental Allergy, 38, 291–2970954-7894http://dx.doi.org/10.1111/j.1365-2222.2007.02887.xmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T17:15:29Zoai:repositorio.ul.pt:10451/11465Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T17:15:29Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy |
| title |
Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy |
| spellingShingle |
Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy Pereira-Santos, M. C. CD25bright Foxp3 Regulatory T cells Specific immunotherapy Venom allergy |
| title_short |
Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy |
| title_full |
Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy |
| title_fullStr |
Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy |
| title_full_unstemmed |
Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy |
| title_sort |
Expansion of circulating Foxp3+D25bright CD4+ T cells during specific venom immunotherapy |
| author |
Pereira-Santos, M. C. |
| author_facet |
Pereira-Santos, M. C. Baptista, A. P. Melo, A. Alves, R. R. Soares, R. S. Pedro, E. Pereira-Barbosa, M. Victorino, R. M. M. Sousa, A. E. |
| author_role |
author |
| author2 |
Baptista, A. P. Melo, A. Alves, R. R. Soares, R. S. Pedro, E. Pereira-Barbosa, M. Victorino, R. M. M. Sousa, A. E. |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Pereira-Santos, M. C. Baptista, A. P. Melo, A. Alves, R. R. Soares, R. S. Pedro, E. Pereira-Barbosa, M. Victorino, R. M. M. Sousa, A. E. |
| dc.subject.por.fl_str_mv |
CD25bright Foxp3 Regulatory T cells Specific immunotherapy Venom allergy |
| topic |
CD25bright Foxp3 Regulatory T cells Specific immunotherapy Venom allergy |
| description |
Journal compilation © 2007 Blackwell Publishing Ltd, Clinical and Experimental Allergy © 2007 The Authors |
| publishDate |
2007 |
| dc.date.none.fl_str_mv |
2007 2007-01-01T00:00:00Z 2014-07-14T14:34:29Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/11465 |
| url |
http://hdl.handle.net/10451/11465 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Clinical and Experimental Allergy, 38, 291–297 0954-7894 http://dx.doi.org/10.1111/j.1365-2222.2007.02887.x |
| dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Blackwell Publishing |
| publisher.none.fl_str_mv |
Blackwell Publishing |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
| _version_ |
1817548815602810880 |