Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/12551 |
Resumo: | Purpose. - Neoadjuvant chemoradiotherapy (nCRT) followed by surgery in patients with resectable esophageal or esophagogastric junctional (GEJ) (Siewert I) cancer is associated with long term overall survival benefits. Up to one third of all patients submitted to nCRT present pathological complete response (pCR). F-18-fluorodeoxyglucose positron emission tomography with CT (F-18-FDG PET-CT) is an important tool for assessing treatment response. Purpose was to assess retrospectively the power of F-18-FDG PET-CT in predicting pCR to evaluate the feasibility of a "watch and wait" approach. Patients and methods. - Retrospective analysis of a prospective database with esophageal or GEJ submitted to pre-operative chemoradiation. Pre and pos treatment F-18-FDG PET-CT were reviewed and classified using visual assessment and PERCIST criteria and the values of maximum standard uptake value were also recorded. Patients were classified as pCR or non-PCR. F-18-FDG PET-CT and pathological findings were compared against each other. Results. - Forty-three patients were included. The median age was 67 years and 90.7% were male. All patients underwent preoperative CRT and were evaluated with F-18-FDG PET-CT pre and post treatment. Transthoracic surgery was performed in all patients. Histological type was adenocarcinoma in 37% and squamous cell carcinoma in 58%. pCR was achieved in 56% of cases. Visual assessment of F-18-FDG PET-CT showed overall sensitivity 57.9%, specificity 62.5% and PERCIST criteria had 100% sensibility and 16.7% specificity. Conclusions. - F-18-FDG PET-CT is not an ideal predictor of pCR but if we use the PERCIST criteria we will have a high sensitivity and negative predictive value, avoiding false negative scans. (C) 2020 Societe francaise de radiotherapie oncologique (SFRO). |
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Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic responseEsophageal cancerNeoadjuvant chemoradiotherapyF-18-FDG PET-CTPathological complete responseWatch and waitPurpose. - Neoadjuvant chemoradiotherapy (nCRT) followed by surgery in patients with resectable esophageal or esophagogastric junctional (GEJ) (Siewert I) cancer is associated with long term overall survival benefits. Up to one third of all patients submitted to nCRT present pathological complete response (pCR). F-18-fluorodeoxyglucose positron emission tomography with CT (F-18-FDG PET-CT) is an important tool for assessing treatment response. Purpose was to assess retrospectively the power of F-18-FDG PET-CT in predicting pCR to evaluate the feasibility of a "watch and wait" approach. Patients and methods. - Retrospective analysis of a prospective database with esophageal or GEJ submitted to pre-operative chemoradiation. Pre and pos treatment F-18-FDG PET-CT were reviewed and classified using visual assessment and PERCIST criteria and the values of maximum standard uptake value were also recorded. Patients were classified as pCR or non-PCR. F-18-FDG PET-CT and pathological findings were compared against each other. Results. - Forty-three patients were included. The median age was 67 years and 90.7% were male. All patients underwent preoperative CRT and were evaluated with F-18-FDG PET-CT pre and post treatment. Transthoracic surgery was performed in all patients. Histological type was adenocarcinoma in 37% and squamous cell carcinoma in 58%. pCR was achieved in 56% of cases. Visual assessment of F-18-FDG PET-CT showed overall sensitivity 57.9%, specificity 62.5% and PERCIST criteria had 100% sensibility and 16.7% specificity. Conclusions. - F-18-FDG PET-CT is not an ideal predictor of pCR but if we use the PERCIST criteria we will have a high sensitivity and negative predictive value, avoiding false negative scans. (C) 2020 Societe francaise de radiotherapie oncologique (SFRO).ElsevierRCIPLCabral, FranciscoCruz, A.Casaca, R.Monteiro, C.Ramos, P.Pedro, C.Brandão, F.Fonseca, R.Ratão, P.Saldado, L.Pinto, IolaAbecasis, N.2021-01-05T15:17:37Z2020-122020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/12551engCABRAL, F.; [et al] – Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response. Cancer Radiotherapie. ISSN 1278-3218. Vol. 24, N.º 8 (2020), pp. 834-8411278-321810.1016/j.canrad.2020.05.013metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:05:40Zoai:repositorio.ipl.pt:10400.21/12551Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:20:37.057853Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response |
title |
Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response |
spellingShingle |
Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response Cabral, Francisco Esophageal cancer Neoadjuvant chemoradiotherapy F-18-FDG PET-CT Pathological complete response Watch and wait |
title_short |
Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response |
title_full |
Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response |
title_fullStr |
Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response |
title_full_unstemmed |
Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response |
title_sort |
Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response |
author |
Cabral, Francisco |
author_facet |
Cabral, Francisco Cruz, A. Casaca, R. Monteiro, C. Ramos, P. Pedro, C. Brandão, F. Fonseca, R. Ratão, P. Saldado, L. Pinto, Iola Abecasis, N. |
author_role |
author |
author2 |
Cruz, A. Casaca, R. Monteiro, C. Ramos, P. Pedro, C. Brandão, F. Fonseca, R. Ratão, P. Saldado, L. Pinto, Iola Abecasis, N. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Cabral, Francisco Cruz, A. Casaca, R. Monteiro, C. Ramos, P. Pedro, C. Brandão, F. Fonseca, R. Ratão, P. Saldado, L. Pinto, Iola Abecasis, N. |
dc.subject.por.fl_str_mv |
Esophageal cancer Neoadjuvant chemoradiotherapy F-18-FDG PET-CT Pathological complete response Watch and wait |
topic |
Esophageal cancer Neoadjuvant chemoradiotherapy F-18-FDG PET-CT Pathological complete response Watch and wait |
description |
Purpose. - Neoadjuvant chemoradiotherapy (nCRT) followed by surgery in patients with resectable esophageal or esophagogastric junctional (GEJ) (Siewert I) cancer is associated with long term overall survival benefits. Up to one third of all patients submitted to nCRT present pathological complete response (pCR). F-18-fluorodeoxyglucose positron emission tomography with CT (F-18-FDG PET-CT) is an important tool for assessing treatment response. Purpose was to assess retrospectively the power of F-18-FDG PET-CT in predicting pCR to evaluate the feasibility of a "watch and wait" approach. Patients and methods. - Retrospective analysis of a prospective database with esophageal or GEJ submitted to pre-operative chemoradiation. Pre and pos treatment F-18-FDG PET-CT were reviewed and classified using visual assessment and PERCIST criteria and the values of maximum standard uptake value were also recorded. Patients were classified as pCR or non-PCR. F-18-FDG PET-CT and pathological findings were compared against each other. Results. - Forty-three patients were included. The median age was 67 years and 90.7% were male. All patients underwent preoperative CRT and were evaluated with F-18-FDG PET-CT pre and post treatment. Transthoracic surgery was performed in all patients. Histological type was adenocarcinoma in 37% and squamous cell carcinoma in 58%. pCR was achieved in 56% of cases. Visual assessment of F-18-FDG PET-CT showed overall sensitivity 57.9%, specificity 62.5% and PERCIST criteria had 100% sensibility and 16.7% specificity. Conclusions. - F-18-FDG PET-CT is not an ideal predictor of pCR but if we use the PERCIST criteria we will have a high sensitivity and negative predictive value, avoiding false negative scans. (C) 2020 Societe francaise de radiotherapie oncologique (SFRO). |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12 2020-12-01T00:00:00Z 2021-01-05T15:17:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/12551 |
url |
http://hdl.handle.net/10400.21/12551 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
CABRAL, F.; [et al] – Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response. Cancer Radiotherapie. ISSN 1278-3218. Vol. 24, N.º 8 (2020), pp. 834-841 1278-3218 10.1016/j.canrad.2020.05.013 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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