Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/75279 |
Resumo: | Staphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve as a scaffold for biofilm formation. S. epidermidis strains are often multidrug resistant and its association with biofilm formation makes these infections hard to treat. Their remarkable ability to form biofilms is widely regarded as its major pathogenic determinant. Although a significant amount of knowledge on its biofilm formation mechanisms has been achieved, we still do not understand how the species survives when exposed to the host harsh environment during invasion. A previous RNA-seq study highlighted that iron-metabolism associated genes were the most up-regulated bacterial genes upon contact with human blood, which suggested that iron acquisition plays an important role in S. epidermidis biofilm development and escape from the host innate immune system. In this perspective article, we review the available literature on the role of iron metabolism on S. epidermidis pathogenesis and propose that exploiting its dependence on iron could be pursued as a viable therapeutic alternative. |
id |
RCAP_92e4c2b55915c9af444ddba4b603b913 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/75279 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success?iron acquisition systemsregulation of iron acquisitionSiderophoresS. epidermidis biofilmsrole of iron in infectionSepidermidis biofilmsCiências Naturais::Ciências BiológicasScience & TechnologyStaphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve as a scaffold for biofilm formation. S. epidermidis strains are often multidrug resistant and its association with biofilm formation makes these infections hard to treat. Their remarkable ability to form biofilms is widely regarded as its major pathogenic determinant. Although a significant amount of knowledge on its biofilm formation mechanisms has been achieved, we still do not understand how the species survives when exposed to the host harsh environment during invasion. A previous RNA-seq study highlighted that iron-metabolism associated genes were the most up-regulated bacterial genes upon contact with human blood, which suggested that iron acquisition plays an important role in S. epidermidis biofilm development and escape from the host innate immune system. In this perspective article, we review the available literature on the role of iron metabolism on S. epidermidis pathogenesis and propose that exploiting its dependence on iron could be pursued as a viable therapeutic alternative.FO is supported by the Fundação para a Ciência e a Tecnologia research project with reference PTDC/BIA-MOL/29553/2017, under the scope of COMPETE2020 (POCI-01-0145-FEDER-029553).info:eu-repo/semantics/publishedVersionFrontiers Media S. A.Universidade do MinhoOliveira, Fernando Eduardo FreitasRohde, HolgerVilanova, ManuelCerca, Nuno2021-11-302021-11-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/75279engOliveira, Fernando E.; Rohde, Holger; Vilanova, Manuel; Cerca, Nuno, Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success?. Frontiers in Cellular and Infection Microbiology, 11(798563), 20212235-298810.3389/fcimb.2021.79856334917520https://www.frontiersin.org/articles/10.3389/fcimb.2021.798563/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:35Zoai:repositorium.sdum.uminho.pt:1822/75279Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:58:36.353393Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success? |
title |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success? |
spellingShingle |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success? Oliveira, Fernando Eduardo Freitas iron acquisition systems regulation of iron acquisition Siderophores S. epidermidis biofilms role of iron in infection S epidermidis biofilms Ciências Naturais::Ciências Biológicas Science & Technology |
title_short |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success? |
title_full |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success? |
title_fullStr |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success? |
title_full_unstemmed |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success? |
title_sort |
Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success? |
author |
Oliveira, Fernando Eduardo Freitas |
author_facet |
Oliveira, Fernando Eduardo Freitas Rohde, Holger Vilanova, Manuel Cerca, Nuno |
author_role |
author |
author2 |
Rohde, Holger Vilanova, Manuel Cerca, Nuno |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Oliveira, Fernando Eduardo Freitas Rohde, Holger Vilanova, Manuel Cerca, Nuno |
dc.subject.por.fl_str_mv |
iron acquisition systems regulation of iron acquisition Siderophores S. epidermidis biofilms role of iron in infection S epidermidis biofilms Ciências Naturais::Ciências Biológicas Science & Technology |
topic |
iron acquisition systems regulation of iron acquisition Siderophores S. epidermidis biofilms role of iron in infection S epidermidis biofilms Ciências Naturais::Ciências Biológicas Science & Technology |
description |
Staphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve as a scaffold for biofilm formation. S. epidermidis strains are often multidrug resistant and its association with biofilm formation makes these infections hard to treat. Their remarkable ability to form biofilms is widely regarded as its major pathogenic determinant. Although a significant amount of knowledge on its biofilm formation mechanisms has been achieved, we still do not understand how the species survives when exposed to the host harsh environment during invasion. A previous RNA-seq study highlighted that iron-metabolism associated genes were the most up-regulated bacterial genes upon contact with human blood, which suggested that iron acquisition plays an important role in S. epidermidis biofilm development and escape from the host innate immune system. In this perspective article, we review the available literature on the role of iron metabolism on S. epidermidis pathogenesis and propose that exploiting its dependence on iron could be pursued as a viable therapeutic alternative. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-30 2021-11-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/75279 |
url |
http://hdl.handle.net/1822/75279 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oliveira, Fernando E.; Rohde, Holger; Vilanova, Manuel; Cerca, Nuno, Fighting Staphylococcus epidermidis biofilm-associated infections: can iron be the key to success?. Frontiers in Cellular and Infection Microbiology, 11(798563), 2021 2235-2988 10.3389/fcimb.2021.798563 34917520 https://www.frontiersin.org/articles/10.3389/fcimb.2021.798563/full |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media S. A. |
publisher.none.fl_str_mv |
Frontiers Media S. A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132376940412928 |