Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies

Detalhes bibliográficos
Autor(a) principal: Filippini, Tommaso
Data de Publicação: 2022
Outros Autores: Halldorsson, Thorhallur I., Capitão, Carolina, Martins, Raquel, Giannakou, Konstantinos, Hogervorst, Janneke, Vinceti, Marco, Åkesson, Agneta, Leander, Karin, Katsonouri, Andromachi, Santos, Osvaldo, Virgolino, Ana, Laguzzi, Federica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52652
Resumo: Copyright © 2022 Filippini, Halldorsson, Capitão, Martins, Giannakou, Hogervorst, Vinceti, Åkesson, Leander, Katsonouri, Santos, Virgolino and Laguzzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studiesAcrylamideDietary exposureNeoplasmsCarcinomaSystematic reviewMeta-analysisEpidemiological studiesCopyright © 2022 Filippini, Halldorsson, Capitão, Martins, Giannakou, Hogervorst, Vinceti, Åkesson, Leander, Katsonouri, Santos, Virgolino and Laguzzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Diet is a main source of acrylamide exposure to humans. Existing observational data on the relationship between dietary exposure to acrylamide and risk of cancer are inconsistent. We performed a systematic review and dose-response meta-analysis of epidemiological studies evaluating the association between dietary acrylamide exposure and several site-specific cancer. A systematic literature search was conducted in PubMed, Scopus, and Web of Science databases until March 7, 2022. Studies were eligible if they were carried out in non-occupationally exposed adults, assessed dietary acrylamide exposure (µg/day) and reported risk estimates of cancer incidence (all but gynecological cancers). Using a random-effects model, we performed a metaanalysis of site-specific cancer risk comparing the highest vs. lowest category of dietary acrylamide exposure. We also carried out a one-stage dose-response metaanalysis assessing the shape of the association. Out of 1,994 papers screened, 31 were eligible (total of 16 studies), which included 1,151,189 participants in total, out of whom 48,175 developed cancer during the median follow-up period of 14.9 years (range 7.3–33.9). The mean estimated dose of dietary acrylamide across studies was 23 µg/day. Pooled analysis showed no association between the highest vs. lowest dietary acrylamide exposure and each site-specific cancer investigated, with no evidence of thresholds in the dose-response meta-analysis. There were also no associations between dietary acrylamide exposure and the risk of cancers when stratifying by smoking status, except for increased risk of lung cancer in smokers. In conclusion, high dietary acrylamide exposure was not associated with an increased risk of site-specific non-gynecological cancer.This work was supported by the European Union Horizon-2020 Research and Innovation Programme under grant agreement No. 733032 HBM4EU.FrontiersRepositório da Universidade de LisboaFilippini, TommasoHalldorsson, Thorhallur I.Capitão, CarolinaMartins, RaquelGiannakou, KonstantinosHogervorst, JannekeVinceti, MarcoÅkesson, AgnetaLeander, KarinKatsonouri, AndromachiSantos, OsvaldoVirgolino, AnaLaguzzi, Federica2022-05-03T14:00:55Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52652engFront. Nutr., 25 April 2022, 9:87560710.3389/fnut.2022.8756072296-861Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:00Zoai:repositorio.ul.pt:10451/52652Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:43.137220Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies
title Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies
spellingShingle Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies
Filippini, Tommaso
Acrylamide
Dietary exposure
Neoplasms
Carcinoma
Systematic review
Meta-analysis
Epidemiological studies
title_short Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies
title_full Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies
title_fullStr Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies
title_full_unstemmed Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies
title_sort Dietary acrylamide exposure and risk of site-specific cancer: a systematic review and dose-response meta-analysis of epidemiological studies
author Filippini, Tommaso
author_facet Filippini, Tommaso
Halldorsson, Thorhallur I.
Capitão, Carolina
Martins, Raquel
Giannakou, Konstantinos
Hogervorst, Janneke
Vinceti, Marco
Åkesson, Agneta
Leander, Karin
Katsonouri, Andromachi
Santos, Osvaldo
Virgolino, Ana
Laguzzi, Federica
author_role author
author2 Halldorsson, Thorhallur I.
Capitão, Carolina
Martins, Raquel
Giannakou, Konstantinos
Hogervorst, Janneke
Vinceti, Marco
Åkesson, Agneta
Leander, Karin
Katsonouri, Andromachi
Santos, Osvaldo
Virgolino, Ana
Laguzzi, Federica
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Filippini, Tommaso
Halldorsson, Thorhallur I.
Capitão, Carolina
Martins, Raquel
Giannakou, Konstantinos
Hogervorst, Janneke
Vinceti, Marco
Åkesson, Agneta
Leander, Karin
Katsonouri, Andromachi
Santos, Osvaldo
Virgolino, Ana
Laguzzi, Federica
dc.subject.por.fl_str_mv Acrylamide
Dietary exposure
Neoplasms
Carcinoma
Systematic review
Meta-analysis
Epidemiological studies
topic Acrylamide
Dietary exposure
Neoplasms
Carcinoma
Systematic review
Meta-analysis
Epidemiological studies
description Copyright © 2022 Filippini, Halldorsson, Capitão, Martins, Giannakou, Hogervorst, Vinceti, Åkesson, Leander, Katsonouri, Santos, Virgolino and Laguzzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-03T14:00:55Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52652
url http://hdl.handle.net/10451/52652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front. Nutr., 25 April 2022, 9:875607
10.3389/fnut.2022.875607
2296-861X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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