Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/80340 |
Resumo: | Upregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p<0.001) and 10 min (p<0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for 'Time after stimulation' (p<0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system. |
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Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopesCiências Naturais::Ciências FísicasScience & TechnologyUpregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p<0.001) and 10 min (p<0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for 'Time after stimulation' (p<0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system.This work was supported by the Federal Ministry of Education and Research, Industrie-in-Klinik-Plattform Program BMBF, Germany (FKZ: 13GW0256). This project was also supported by the Portuguese Foundation for Science and Technology (FCT) PTDC/FIS-OPT/0677/2014, the Strategic Funding UID/FIS/04650/2013 at Center of Physics, UMinho, and predoctoral grant SFRH/BD/136684/2018 to AAS. In addition, we would like to thank Nikita Wong for some literature search and language proofreading.Nature ResearchUniversidade do MinhoAmorim-de-Sousa, AnaSchilling, TimFernandes, PauloSeshadri, YeshwanthBahmani, HamedGonzález-Méijome, José Manuel2021-04-292021-04-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/80340engAmorim-de-Sousa, A., Schilling, T., Fernandes, P., Seshadri, Y., Bahmani, H., & González-Méijome, J. M. (2021). Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes. Scientific Reports, 11(1), 1-102045-23222045-232210.1038/s41598-021-88459-233927248https://www.nature.com/articles/s41598-021-88459-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:04:50Zoai:repositorium.sdum.uminho.pt:1822/80340Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:55:09.619138Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes |
title |
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes |
spellingShingle |
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes Amorim-de-Sousa, Ana Ciências Naturais::Ciências Físicas Science & Technology |
title_short |
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes |
title_full |
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes |
title_fullStr |
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes |
title_full_unstemmed |
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes |
title_sort |
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes |
author |
Amorim-de-Sousa, Ana |
author_facet |
Amorim-de-Sousa, Ana Schilling, Tim Fernandes, Paulo Seshadri, Yeshwanth Bahmani, Hamed González-Méijome, José Manuel |
author_role |
author |
author2 |
Schilling, Tim Fernandes, Paulo Seshadri, Yeshwanth Bahmani, Hamed González-Méijome, José Manuel |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Amorim-de-Sousa, Ana Schilling, Tim Fernandes, Paulo Seshadri, Yeshwanth Bahmani, Hamed González-Méijome, José Manuel |
dc.subject.por.fl_str_mv |
Ciências Naturais::Ciências Físicas Science & Technology |
topic |
Ciências Naturais::Ciências Físicas Science & Technology |
description |
Upregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p<0.001) and 10 min (p<0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for 'Time after stimulation' (p<0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-29 2021-04-29T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/80340 |
url |
https://hdl.handle.net/1822/80340 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Amorim-de-Sousa, A., Schilling, T., Fernandes, P., Seshadri, Y., Bahmani, H., & González-Méijome, J. M. (2021). Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes. Scientific Reports, 11(1), 1-10 2045-2322 2045-2322 10.1038/s41598-021-88459-2 33927248 https://www.nature.com/articles/s41598-021-88459-2 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Research |
publisher.none.fl_str_mv |
Nature Research |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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