Elucidating the physiological role of the DsrJ cytochrome in dissimilatory sulfate metabolism

• Autor(a) principal: Bernardino, Raquel M.
• Data de Publicação: 2022
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/163216
• topic: Sulfate-reducing organisms; Dissimilatory sulfate reduction; Respiratory membrane complexes; DsrMKJOP; Domínio/Área Científica::Ciências Naturais

"The increase of sulfidogenic (sulfide-producing) bacteria in the human gut, as a result of dysbiosis, is often associated with chronic inflammatory disorders. The pathogenesis of sulfidogenic bacteria is mainly due to the toxicity of their main metabolic product, sulfide. To prevent the development of such diseases, it is crucial to understand the energy metabolism of these bacteria. Desulfovibrio vulgaris Hildenborough, a sulfate-reducing bacterium that is a member of the human gut microbiota, is one of the best-studied model organisms for the dissimilatory reduction of sulfate to sulfide. Nonetheless, its energy-conserving mechanisms are still not fully understood, particularly, the function of the widely conserved DsrMKJOP transmembrane complex. The Dsr complex is likely involved in the reduction of the DsrC-trisulfide with the concomitant production of sulfide, through the DsrMK module. However, the function of the DsrJOP module is more puzzling, namely that of its periplasmic subunit, DsrJ.(...)"