Portuguese contributions to the discovery and characterization of the embryonic molecular clock
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/67603 |
Resumo: | Embryonic development is strictly regulated both in time and in space. This extraordinary control is clearly evidenced during the process of somitogenesis. In this process, pairs of somites are formed periodically, such that the time required to form a new somite pair is constant and species specific. The tight temporal control underlying somitogenesis has been shown to depend upon a molecular clock, manifested by the cyclic expression of an increasing number of genes in the unsegmented paraxial mesoderm. Portuguese researchers have been intimately connected to the achievements that have been made in this new field of research: the somitogenesis molecular clock. This article intends to report the Portuguese contributions to the discovery and characterization of the molecular clock underlying somite formation and possibly other embryonic processes. This work inspired many scientists around the world and it has been followed in Portugal by teams that keep on pursuing the characterization of the machinery of this molecular oscillator and its function in the acquisition of both temporal and positional information during development. |
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Portuguese contributions to the discovery and characterization of the embryonic molecular clockAnimalsAvian ProteinsBasic Helix-Loop-Helix Transcription FactorsBiological ClocksBody PatterningChick EmbryoGene Expression Regulation, DevelopmentalHistory, 20th CenturyHistory, 21st CenturyIn Situ HybridizationModels, BiologicalPortugalResearch PersonnelSomitesTime FactorsSomitogenesisTemporal controlLimb budPositional informationL-R asymmetryL-R asymmetrScience & TechnologyEmbryonic development is strictly regulated both in time and in space. This extraordinary control is clearly evidenced during the process of somitogenesis. In this process, pairs of somites are formed periodically, such that the time required to form a new somite pair is constant and species specific. The tight temporal control underlying somitogenesis has been shown to depend upon a molecular clock, manifested by the cyclic expression of an increasing number of genes in the unsegmented paraxial mesoderm. Portuguese researchers have been intimately connected to the achievements that have been made in this new field of research: the somitogenesis molecular clock. This article intends to report the Portuguese contributions to the discovery and characterization of the molecular clock underlying somite formation and possibly other embryonic processes. This work inspired many scientists around the world and it has been followed in Portugal by teams that keep on pursuing the characterization of the machinery of this molecular oscillator and its function in the acquisition of both temporal and positional information during development.Financial support was provided by FCT/FEDER (POCTI/BCI/42040/2001) and by the EU/FP6-Network of Excellence-Cells into Organs. S.P. (SFRH/BPD/26638/2006) was supported by FCT, Portugal.UBC PressUniversidade do MinhoPascoal, Susana Alexandra RodriguesPalmeirim, Isabel20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/67603eng0214-62821696-354710.1387/ijdb.072285sp19247956info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:49:12Zoai:repositorium.sdum.uminho.pt:1822/67603Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:47:37.850455Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Portuguese contributions to the discovery and characterization of the embryonic molecular clock |
title |
Portuguese contributions to the discovery and characterization of the embryonic molecular clock |
spellingShingle |
Portuguese contributions to the discovery and characterization of the embryonic molecular clock Pascoal, Susana Alexandra Rodrigues Animals Avian Proteins Basic Helix-Loop-Helix Transcription Factors Biological Clocks Body Patterning Chick Embryo Gene Expression Regulation, Developmental History, 20th Century History, 21st Century In Situ Hybridization Models, Biological Portugal Research Personnel Somites Time Factors Somitogenesis Temporal control Limb bud Positional information L-R asymmetry L-R asymmetr Science & Technology |
title_short |
Portuguese contributions to the discovery and characterization of the embryonic molecular clock |
title_full |
Portuguese contributions to the discovery and characterization of the embryonic molecular clock |
title_fullStr |
Portuguese contributions to the discovery and characterization of the embryonic molecular clock |
title_full_unstemmed |
Portuguese contributions to the discovery and characterization of the embryonic molecular clock |
title_sort |
Portuguese contributions to the discovery and characterization of the embryonic molecular clock |
author |
Pascoal, Susana Alexandra Rodrigues |
author_facet |
Pascoal, Susana Alexandra Rodrigues Palmeirim, Isabel |
author_role |
author |
author2 |
Palmeirim, Isabel |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pascoal, Susana Alexandra Rodrigues Palmeirim, Isabel |
dc.subject.por.fl_str_mv |
Animals Avian Proteins Basic Helix-Loop-Helix Transcription Factors Biological Clocks Body Patterning Chick Embryo Gene Expression Regulation, Developmental History, 20th Century History, 21st Century In Situ Hybridization Models, Biological Portugal Research Personnel Somites Time Factors Somitogenesis Temporal control Limb bud Positional information L-R asymmetry L-R asymmetr Science & Technology |
topic |
Animals Avian Proteins Basic Helix-Loop-Helix Transcription Factors Biological Clocks Body Patterning Chick Embryo Gene Expression Regulation, Developmental History, 20th Century History, 21st Century In Situ Hybridization Models, Biological Portugal Research Personnel Somites Time Factors Somitogenesis Temporal control Limb bud Positional information L-R asymmetry L-R asymmetr Science & Technology |
description |
Embryonic development is strictly regulated both in time and in space. This extraordinary control is clearly evidenced during the process of somitogenesis. In this process, pairs of somites are formed periodically, such that the time required to form a new somite pair is constant and species specific. The tight temporal control underlying somitogenesis has been shown to depend upon a molecular clock, manifested by the cyclic expression of an increasing number of genes in the unsegmented paraxial mesoderm. Portuguese researchers have been intimately connected to the achievements that have been made in this new field of research: the somitogenesis molecular clock. This article intends to report the Portuguese contributions to the discovery and characterization of the molecular clock underlying somite formation and possibly other embryonic processes. This work inspired many scientists around the world and it has been followed in Portugal by teams that keep on pursuing the characterization of the machinery of this molecular oscillator and its function in the acquisition of both temporal and positional information during development. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 2009-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/67603 |
url |
http://hdl.handle.net/1822/67603 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0214-6282 1696-3547 10.1387/ijdb.072285sp 19247956 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UBC Press |
publisher.none.fl_str_mv |
UBC Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133050765836288 |